The Enzymes
Academic Press
3rd Edition
Published on 1. December 1983
766 pages
978-0-08-086593-5 (ISBN)
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The Enzymes
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Enzymes: Lipid Enzymology v. 16
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12/1983
3rd Edition
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The Enzymes
Molecular Machines Involved in Protein Transport across Cellular Membranes
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Content
- Front Cover
- The Enzymes, Volume XVI
- Copyright Page
- Contents
- List of Contributors
- Preface
- Section I: Fatty Acid Biosynthesis
- Chapter 1. Structure and Mechanism of Fatty Acid Synthetase
- I. Introduction
- II. Fatty Acid Synthetases of Eukaryotes
- III. Component Activities
- IV. Mechanism of Action of Fatty Acid Synthetase
- Chapter 2. Fatty Acid Desaturation
- I. Introduction
- II. Enzymology of Desaturation
- III. Regulation of Desaturation
- IV. Desaturation in Other Systems
- Section II: Glyceride Enzymology
- Chapter 3. Enzymes of Triacylglycerol Formation in Mammals
- I. Introduction and Perspective
- II. Glycerol 3-Phosphate Acyltransferase
- III. Peroxisomal Dihydroxyacetone Phosphate Acyltransferase
- IV. Acyldihydroxyacetone Phosphate Reductase
- V. 1-Acylglycerol 3-Phosphate Acyltransferase
- VI. Phosphatidic Acid Phosphatase
- VII. 2-Monoacylglycerol Acyltransferase
- VIII. Diacylglycerol Acyltransferase
- Chapter 4. Glyceride Digestion
- I. Introduction
- II. Enzymes in Glyceride Digestion
- III. Fat Digestion in the Neonate
- Chapter 5. Lipoprotein Lipase and Hepatic Lipase
- I. Introduction and Perspective
- II. Hepatic Triglyceride Lipase (H-TGL)
- III. Lipoprotein Lipase (LpL)
- IV. Summary and Conclusions
- Chapter 6. Hormone-Sensitive Lipase of Adipose Tissue
- I. Historical Background and Metabolic Significance
- II. Definitions and Methods of Assay
- III. Purification and Properties
- IV. Mechanism of Regulation
- V. Effect of Insulin
- VI. Studies of Hormone-Sensitive Lipase in Cultured Cell Lines
- Section III: Phospholipid Enzymology
- Chapter 7. Synthesis of Phospholipids in Animal Cells
- I. Introduction
- II. The Phospholipid Composition of Animal Cell Membranes
- III. Possible Roles for Phospholipid Heterogeneity
- IV. Biosynthesis of Common Precursors
- V. Biosynthesis of Diacylglycerol, the Zwitterionic Phospholipids, and Phosphatidylserine
- VI. Biosynthesis of CDP-Diglyceride and Anionic Phospholipids
- VII. Biosynthesis of Sphingomyelin
- VIII. Catabolism of Membrane Phospholipids
- IX. Regulatory Aspects of Membrane Phospholipid Biogenesis
- X. Perspectives
- Chapter 8. Formation of Bacterial Glycerolipids
- I. Introduction
- II. Phosphatidic Acid (1,2-diacyl-sn-glyceroI 3-phosphate)
- III. CDPdiacylglycerol
- IV. Phosphatidylserine and Phosphatidylethanolamine
- V. Phosphatidylcholine
- VI. Phosphatidylglycerophosphate and Phosphatidylglycerol
- VII. Aminoacyl Phosphatidylglycerol
- VIII. Fatty Acyl Phosphatidylglycerol
- IX. Diphosphatidylglycerol (Cardiolipin)
- X. Diacylglycerol
- XI. Glycosylglycerolipids
- XII. Phosphoglycoglycerolipids
- Chapter 9. Phospholipases
- I. Introduction and Perspective
- II. Purification and Properties
- III. Interfacial Issues
- IV. Reactions Catalyzed
- V. Biological Role
- VI. Research Applications
- Section IV: Sphingolipid Enzymology
- Chapter 10. Sphingolipid Formation
- I. Introduction
- II. Synthesis of Ceramide
- III. Synthesis of Cerebrosides
- IV. Synthesis of Sulfatides
- V. Synthesis of Gangliosides
- VI. Synthesis of Neutral Long-Chain Glycosphingolipids
- VII. Sphingomyelin
- VIII. Sphingolipid Synthesis and Membrane Function
- Chapter 11. Sphingolipid Hydrolysis
- I. Introduction and Perspective
- II. Purification and Properties
- III. The Reactions Catalyzed
- IV. Biological Role
- V. Research Applications
- Chapter 12. Activator Proteins for Sphingolipid Hydrolysis
- I. Introduction
- II. Isolation and Characterization of Activator Proteins
- III. Sphingolipid Storage Diseases Caused by Deficiency of Activator Proteins
- IV. Presence of Activator Proteins for Enzymic Hydrolysis of Glycosphingolipids in Normal Human Urine
- V. Discussion
- Section V: Glycolipid Enzymology
- Chapter 13. Glycosylated Lipid Intermediates Involved in Glycoprotein Biosynthesis
- I. Introduction
- II. Structure of Asparagine-Linked Carbohydrate Sidechains
- III. Reactions of the Microsomal Dolichol Pathway-General Properties
- IV. Transfer of the Oligosaccharide Core from Dolichol to Polypeptide Acceptors: Oligosaccharide Transferase
- V. Trimming of Glycosylamine-Linked Carbohydrate Sidechains
- VI. Maturation: Golgi Glycosyltransferases
- VII. Conclusions
- Section VI: Cholesterol Enzymology
- Chapter 14. Mammalian HMG-CoA Reductase and Its Regulation
- I. Introduction and Perspective
- II. Purification and Properties
- III. The Reactions Catalyzed
- IV. Inhibitors
- V. Regulation
- Chapter 15. Acyl Coenzyme A: Cholesterol O-Acyltransferase
- I. Introduction and Perspective
- II. Properties
- III. Regulation by Sterol
- IV. Acyl Coenzyme A: Cholesterol O-Acyltransferase and Very-Low-Density Lipoprotein Cholesterol Ester
- Section VII: Special Topics
- Chapter 16. Enzymes in the Biosynthesis and Catabolism of the Eicosanoids: Prostaglandins, Thromboxanes, Leukotrienes and Hydroxy Fatty Acids
- I. Introduction
- II. The Enzymes of Prostaglandin and Thromboxane Biosynthesis
- III. Enzymes in the Prostaglandin Catabolic Cascade
- IV. Lipoxygenases
- V. Leukotrienes
- Chapter 17. Topography of Membrane-Bound Enzymes That Metabolize Complex Lipids
- I. Introduction and Perspective
- II. Experimental Approaches
- III. Enzyme Topography
- IV. Discussion
- Chapter 18. Carnitine Acyltransferases
- I. Introduction
- II. Reactions Catalyzed
- III. Number of Carnitine Acyltransferases
- IV. CPT: Purification, Properties, and Regulation
- V. Pathophysiology and Clinical Aspects
- Chapter 19. P-450 Oxygenases in Lipid Transformation
- I. Introduction
- II. Forms of Cytochrome P-450 That Are Specific for Lipid Metabolism
- III. Forms of Cytochrome P-450 Involved in the Metabolism of Lipids and Xenobiotics
- Chapter 20. Enzyme Replacement Therapy
- I. Introduction and Perspective
- II. Early Trials
- III. Prospective Enzyme Replacement Studies in Gaucher's Disease
- IV. Targeting Enzymes to Storage Cells
- V. Replacement of Enzymes in the Central Nervous System
- VI. Concluding Remarks
- Author Index
- Subject Index
- Contents of Other Volumes
