The Enzymes

Name: The Enzymes
Brand: Academic Press
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Academic Press

3rd Edition

Published on 5. September 1974

885 pages

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978-0-08-086587-4 (ISBN)

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Content

Front Cover
The Enzymes
Copyright Page
Contents
List of Contributors
Preface
Contents of Other Volumes
Chapter 1. Polypeptide Chain Initiation
I. Introduction
II. Procaryotes
III. Eucaryotes
IV. Regulation of Chain Initiation
Chapter 2. Protein Synthesis-Peptide Chain Elongation
I. Introduction
II. The Bacterial Elongation Factors
III. Elongation and the Ribosome
IV. Elongation and the Stringent Response
V. EF-Tn and EF-Ts as Subunits of Q/ß Repticase
VI. Plant Viral RNA's and Their 3'-Terminal tRNA-Like Sequence
VII. Concluding Remarks
Chapter 3. Polypeptide Chain Termination
I. Introduction
II. Requirements for Peptide Chain Termination
III. Mechanism of Peptide Chain Termination
IV. The Relationship of Peptide Chain Termination to Other Events of Protein Synthesis
V. Summary
Chapter 4. Bacterial DNA Polymerases
I. Variety of DNA Polymerases
II. Isolation and Physicochemical Properties
III. The Catalytic Reactions
IV. Proteolytic Cleavage: Two Enzymes in One Polypeptide
V. Physiological Roles
VI. Comparison of Properties of Polymerases
Chapter 5. Terminal Deoxynucleotidyl Transferase
I. Introduction
II. The Nature of the Reaction
III. The Statistics of Polymerization
IV. The Mechanism of the Reaction
V. Practical Applications of Transferase Catalysis
VI. Biological Directions
Chapter 6. Eucaryotic DNA Polymerases
I. Introduction
II. Occurrence
III. Classification
IV. Purification
V. Molecular Properties
VI. Catalytic Properties
VII. Fidelity of DNA Synthesis
VIII. Templates and Initiators
IX. Concluding Remarks
Chapter 7. RNA Tumor Virus DNA Polymerases
I. Introduction
II. RNA Virus with a Virion DNA Polymerase
III. Purification
IV. Properties of Purified DNA Polymerases
V. Properties of Catalytic Reaction
VI. Inhibitors
VII. Biological Role
VIII. Comparison with Other DNA Polymerases
Chapter 8. DNA Joining Enzymes (Ligases)
I. Introduction
II. Isolation and Physical Properties of E. coli DNA Ligase
III. Mechanism of Phosphodiester Bond Synthesis
IV. Role of DNA Ligase in Vivo
Chapter 9. Eucaryotic RNA Polymerases
I. Introduction
II. Nuclear Enzymes
III. Organelle DNA-Dependent RNA Polymerases
IV. Conclusions
Chapter 10. Bacterial DNA-Dependent RNA Polymerase
I. Background
II. Molecular Properties
III. Catalytic Properties
Chapter 11. Mitochondrial and Chloroplast ATPases
I. Introduction
II. Mitochondria ATPase
III. Chloroplast ATPase
Chapter 12. Bacterial Membrane ATPase
I. Introduction
II. Streptococcus faecalis Membrane ATPase
III. Other Bacterial ATPases
Chapter 13. Sarcoplasmic Membrane ATPases
I. Introduction
II. Sarcoplasmic Membranes in Situ
III. Isolated Sarcoplasmic Membranes
IV. Composition of the Sarcoplasmic Membranes
V. Physical Properties of the Lipoprotein Structure of the Sarcoplasmi Membranes
VI. Calcium-Independent and Calcium-Dependent ATP Hydrolysis
VII. Calcium Binding and Transport by the Sarcoplasmic Membranes
VIII. Calcium Efflux-Dependent ATP Synthesis
IX. Reaction Sequence of Calcium Translocation and Phosphoryl Transfer
X. The Function of the Lipids in the Sarcoplasmic Membranes
Chapter 14. Fatty Acyl-CoA Synthetases
I. Introduction
II. Molecular Properties of Acetate:CoA Ligase (AMP)
III. Catalytic Properties of the Fatty Acid:CoA Iigases (AMP)
Chapter 15. Aminoacyl-tRNA Synthetases
I. Introduction
II. Occurrence and Distribution
III. Molecular Properties of Aminoacyl-tRNA Synthetases
IV. Catalytic Properties
V. tRNA
VI. Genetics of Aminoacyl-tRNA Synthetases
VII. Regulation of the Biosynthesis of Aminoacyl-tRNA Synthetases
VIII. Involvement of Aminoacyl-tRNA Synthetases in the Regulation
IX. Conclusion
Chapter 16. CTP Synthetase and Related Enzymes
I. Introduction
II. History
III. Purification of the Enzyme
IV. The Structure of CTP Synthetase
V. The Covalent Chemistry of CTP Synthetase Reaction
VI. The Allosteric Control-GTP
VII. Cooperative Effects
VIII. DON and Half-of-the-Sites Reactivity
IX. The Role of ATP and UTP
X. Related Enzymes
XI. Conclusion
Chapter 17. Asparagine Synthesis
I. Introduction
II. Asparagine Synthetases from Bacterial Sources
III. Glutamine-Dependent Asparagine Synthetase
IV. Discussion
Chapter 18. Succinyl-CoA Synthetase
I. Introduction
II. Molecular Properties
III. Catalytic Properties
Chapter 19. Phorphoribosylpyrophosphate Synthetase and Related Pyrophosphokinases
I. Introduction
II. Phosphoribosylpyrophosphate Synthetase
III. Other Pyrophosphokinases
IV. Conclusion
Chapter 20. Phosphoenolpyruvate Synthetase and Pyruvate Phosphate Dikinase
I. Introduction
II. Molecular Properties
III. Catalytic Properties
Chapter 21. Sulfation Linked to ATP Cleavage
I. Introduction
II. ATP-Sulfurylase
III. Adenylylsulfate Kinase
IV. ADP-Sulfurylase
V. Regulation and Control
Chapter 22. Glutathione Synthesis
I. Introduction
II. ?-Glutamyl-Cysteine Synthetase
III. Glutathione Synthetase
IV. General Discussion
Chapter 23. Glutamine Synthetase of Mammals
I. Introduction
II. Physical and Chemical Properties
III. General Catalytic Properties
IV. Partial Reactions
V. Evidence for the Intermediate Formation of y-Glutamyl Phosphate
VI. Mapping of the Active Site
VII. Mechanism of the Reaction
VIII. Regulation of Glutamine Synthetase Activity
Chapter 24. The Glutamine Synthetase of Escherichia coli: Structure and Control
I. Introduction
II. General Considerations
III. Regulation of Glutamine Synthetase Activity
IV. Properties of Adenylylated and Unadenylylated Glutamine Synthetase
V. Multiple Molecular Forms of Glutamine Synthetase
Author Index
Subject Index

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