
The Enzymes
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Content
- Front Cover
- The Enzymes, Volume VII
- Copyright Page
- Contents
- List of Contributors
- Preface
- Chapter 1. Tryptophan Synthetase
- I. Introduction
- II. Molecular Properties
- III. Catalytic Properties
- Chapter 2. Pyridoxal-Linked Elimination and Replacement Reactions
- I. Introduction
- II. ß-Elimination Reactions
- III . ß-Replacement Reactions
- IV. ? Elimination
- V. ? Elimination and Replacement
- VI. Absorption Spectra and Mechanisms
- Chapter 3. The Enzymic Elimination of Ammonia
- I. Introduction
- II. General Considerations
- III. Free Energy of Ammonia Elimination
- IV. Stereochemistry of the Enzymic Eliminations
- V. Aspartate and 3-Methylaspartate Ammonia-lyases
- VI. Histidine and Phenylalanine Ammonia-lyases
- VII. Concluding Remarks
- Chapter 4. Argininosuccinases and Adenylosuccinases
- I. General Features of C-N Cleavage
- II. Argininosuccinases
- III. Bovine Liver Argininosuccinase
- IV. Bovine Kidney Argininosuccinase
- V. Argininosuccinase of Neurospora
- VI. Argininosuccinase of Pea Seeds
- VII. Adenylosuccinases
- VIII. Studies on AICAR-Succinate Cleaving Activity
- IX. Adenylosuccinase of Yeast
- X. Adenylosuccinase of Neurospora
- XI. Stereospecificity of Addition or Elimination
- XII. Mechanism of Action
- Chapter 5. Epoxidases
- I. Introduction
- II. Tartrate Epoxidase
- III. Glutathione S-Epoxidetransferase
- IV. Other Epoxidase Activities
- Chapter 6. Aldolases
- I. Introduction
- II. Schiff Base-Forming Aldolases (Class I)
- III. Metalloaldolases (Class II)
- Chapter 7. Transaldolase
- I. Introduction
- II. History
- III. Distribution and Purification
- IV. Enzymic Properties
- V. Molecular Properties
- VI. Mechanism of Action
- VII. Metabolic Role
- Chapter 8. 2-Keto-3-deoxy-6-phosphogluconic and Related Aldolases
- I. Introduction
- II. 2-Keto-3-deoxy-6-phosphogluconic Aldolase
- III. 2-Keto-3-deoxy-6-phosphogalactonic Aldolase
- IV. 2-Keto-3deoxy-L-arabonate and 2-Keto-3-dcoxy-D-fuconate Aldolase
- V. 2-Keto-3-deoxy-D-glucarate Aldolase
- VI. 2-Keto-3-deoxy-manno-octosonate Aldolase
- VII. N-Acetylneuraminate Aldolase
- VIII. 4-Hydroxy-2-ketoglutarate Aldolasc
- IX. ?-Methyl-?-hydroxy-a-ketoglutaric Aldolase
- Chapter 9. Other Deoxy Sugar Aldolases
- I. Introduction
- II. L-Rhamnulose 1-Phosphate Aldolase
- III. L-Fuculose 1-Phosphate Aldolase
- IV. 2-Deoxyribose 5-Phosphate Aldolase
- Chapter 10. d-Aminolevulinic Acid Dehydratase
- I. Introduction
- II. Molecular Properties
- III. Catalytic Properties
- IV. Nature of the Active Site
- V. Mechanism of Porphobilinogen Synthesis
- Chapter 11. d-Aminolevulinic Acid Synthetase
- I. Introduction
- II. Molecular Properties
- III. The Catalytic Reaction
- IV. Analogous Reactions
- Chapter 12. Citrate Cleavage and Related Enzymes
- I. Introduction
- II. Citrate Synthase
- III. ATP Citrate Lyase
- IV. Citrate Lyase
- V. Isoscitrate Lyase
- Chapter 13. Thiolase
- I. Introduction
- II. Isolation and Stability
- III. Molecular Properties
- IV. Subunit Structure and Reversible Dissociaticbn
- V. Catalytic Properties
- VI. Biological Function
- VII. Inhibitors
- VIII. Enayme Mechanism
- IX. Amino Acid Sequence at the Activity Site
- Chapter 14. Acyl-CoA Ligases
- I. Introduction
- II. General Topics
- III. Glyoxylate Condensing Enzymes
- IV. Condensation of Acetyl-CoA and Keto Acids
- V. Cleavage Reactions
- Chapter 15. a-Glucan Phosphorylases-Chemical and Physical Basis of Catalysis and Regulation
- I. Introduction
- II. Catalytic Reaction
- III. Enzyme Structure
- IV. Mechanism of Enzyme Catalysis
- V. Mechanism of Regulation
- Chapter 16. Purine Nucleoside Phosphorylase
- I. Introduction
- II. Metabolic Functions
- III. Molecular and Catalytic Properties
- Chapter 17. Disaccharide Phosphorylases
- I. Introduction
- II. Purification and Properties of Sucrose Phosphorylase
- III. Kinetics of Sucrose Phosphorylase Reactions
- IV. Isolation and Properties of a Covalent Glucose-Enzyme
- V. Configuration of the Glucose-Enzyme Bond
- VI. The Mechanism of Sucrose Phosphorylase Catalysis
- VII. Substrate Specificity of the Disaccharide Phosphorylases
- VIII. Reactions of Sucrose Phosphorylase in Which Water and Other Alcohols Function as Acceptors
- Chapter 18. Polynucleotide Phosphorylase
- I. Introduction
- II. Polynucleotide Phosphorylase in Vivo
- III. The Active Protein
- IV. Catalytic Reactions
- Chapter 19. The Lipases
- I. Introduction
- II. Pancreatic Lipase
- III. Other Lipases of the Gastrointestinal Tract
- IV. Tissue Lipases
- V. Milk Lipases
- VI. Castor Bean Lipase
- VII. Lipases of Microorganisms
- Chapter 20. ß-Galactosidase
- I. Introduction
- II. Occurrence
- III. Assay and Standardization
- IV. Purification
- V. Physicochemical Properties
- VI. Chemical Properties
- VII. Immunological Properties
- VIII. Enzymic Properties
- Chapter 21. Vertebrate Lysozymes
- I. Introduction
- II. Preparation, Composition, and Sequence
- III. X-Ray Studies of Structure and Activity
- IV. Physical Properties
- V. Denaturation
- VI. Chemical Modifications and Properties of Individual Residues
- VII. Saccharide Binding
- VIII. Substrates, Kinetics and Mechanism
- Author Index
- Subject Index
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