Drug Utilization Research
Description
Reviews / Votes
"Overall, this is a great resource for healthcare providers and a great learning tool for students. It is well written and includes many helpful figures and tables. The references to specific pages for more in-depth explanations of certain topics make this book very user friendly." (Doody Enterprises, 2016)More details
Other editions
Additional editions
Persons
Monique Elseviers, Centre for Research and Innovation in Care, University of Antwerp, Belgium.
Björn Wettermark, Associate Professor in Pharmacoepidemiology, Karolinska Institutet, Stockholm, Sweden.
Morten Andersen, Visiting Professor, Centre for Pharmacoepidemiology, Karolinska Institutet, Stockholm, Sweden; Senior Physician at the Department of Clinical Pharmacology, Karolinska University Hospital, Stockholm, Sweden; Senior Researcher at the Research Unit for General Practice, University of Southern Denmark, Denmark.
Ria Benko, Associate Professor, Department of Clinical Pharmacy at the University of Szeged, Hungary.
Marion Bennie, Professor of Pharmacy Practice, University of Strathclyde, UK; Chief Pharmaceutical Adviser, NHS National Services Scotland, UK.
Brian Godman, Research Scientist, Karolinska Institutet, Stockholm, Sweden.
Janet Krska, Professor of Clinical and Professional Pharmacy, Medway School of Pharmacy, Universities of Greenwich and Kent, UK.
Elisabetta Poluzzi, Assistant Professor of Pharmacology, Department of Pharmacology, Faculty of Medicine, University of Bologna, Italy.
Katja Taxis, Associate Professor of Pharmacotherapy and Clinical Pharmacy, University of Groningen, Netherlands.
Vera Vlahovic-Palcevski, Professor, Department of Pharmacology, University of Rijeka Medical School, Croatia; Specialist in Clinical Pharmacology, University Hospital Rijeka, Croatia.
Robert Vander Stichele, practicing family physician in Ghent, Belgium.
Content
List of contributors viii
Acknowledgements xiv
About the companion website xix
Part 1 Introduction
1 Introduction to drug utilization research 3 Björn Wettermark, Monique Elseviers, Anna Birna Almarsdóttir, Morten Andersen, Ria Benko, Marion Bennie, Irene Eriksson, Brian Godman, Janet Krska, Elisabetta Poluzzi, Katja Taxis, Robert Vander Stichele, Vera Vlahovic-Palcevski
Part 2 Methodology
2 Study designs in drug utilization research 15 Björn Wettermark, Mirko Di Martino, Monique Elseviers
3 Primary data collection for drug utilization research 29 Tatiana Chama Borges Luz, Evalill Nilsson
4 Secondary data sources for drug utilization research 39 Irene Eriksson, Luisa Ibáñez
5 Classifi cation systems for drugs and diseases 49 Marit Rønning, Stuart McTaggart
6 Measurement units of drug utilization 58 Hege Salvesen Blix
7 Individual-level drug utilization analyses 68 Jesper Hallas, Henrik Støvring, Anton Pottegård
8 Measurement of drug expenditure 77 Sabine Vogler, Jaana E. Martikainen
9 Basic statistical methods in drug utilization research 88 Douglas T. Steinke, Monique Elseviers
10 Visualization of drug utilization data 99 Maria Matuz, Ria Benko, Mikael Hoffmann
11 Multilevel analyses in drug utilization research 116 Juan Merlo
12 Defi ning and developing quality indicators for drug utilization 126 Stephen Campbell, Björn Wettermark, Morten Andersen
13 Qualitative methods in drug utilization research 139 Anna Birna Almarsdóttir, Pia Bastholm Rahmner
Part 3 Applied drug utilization research
Section A Comparative drug utilization research
14 Comparison of drug utilization across different geographical areas 153 Vera Vlahovic-Palcevski, Björn Wettermark, Luisa Ibáñez, Robert Vander Stichele
15 Comparison of drug utilization in different health care settings 160 Sean MacBride-Stewart, Ksenia Zagorodnikova, Irene Langner, Gisbert W. Selke
16 Time-dependent and seasonal variations in drug utilization 173 Eric Van Ganse, Laurent Laforest, Niels Adriaenssens
17 Comparative studies of patient and prescriber characteristics 184 Irene Eriksson, Ulf Bergman, Vera Vlahovic-Palcevski, Mia von Euler
18 Comparative studies of health systems 194 Tatiana Chama Borges Luz, Claudia Garcia Serpa Osorio-de-Castro, Björn Wettermark
Section B Drug utilization and health policy
19 Drug utilization and health policy 203 Brian Godman, Hye Young Kwon, Marion Bennie, Anna Birna Almarsdóttir
20 Managed introduction of new drugs 210 Brian Godman, Roberta Joppi, Marion Bennie, Saira Jan, Björn Wettermark
21 Management of drugs in the health care system 222 Brian Godman, Marion Bennie, Claudia Garcia Serpa Osorio-de-Castro, Vu Thi Thu Huong, Saira Jan
22 The pharmaceutical industry and health policy 231 Richard Torbett, Donald Han, Indranil Bagchi
Section C Drug utilization in specific populations
23 Drug utilization in pregnant women 240 Hedvig Nordeng
24 Drug utilization in the paediatric population 248 Antje Neubert, Katja Taxis, Ian C.K. Wong
25 Drug utilization in older people 259 Katja Taxis, David O'Sullivan, Shane Cullinan, Stephen Byrne
Section D Drug utilization in specific therapeutic areas
26 Drug utilization research in the area of antibiotics 270 Ria Benko, Marion Bennie, Samuel Coenen
27 Drug utilization research in the area of cardiovascular medicines 284 Elisabetta Poluzzi, Maarit Jaana Korhonen
28 Drug utilization research in the area of analgesics and psychotropics 294 Helga Zoëga, Alesha Smith, Nadia Barozzi
29 Drug utilization research in the area of biologicals 302 Carlo Piccinni, Luigi Naldi, Martin Neovius
30 Drug utilization research in the area of cancer drugs 315 Nils Wilking, Thomas Hofmarcher, Ulla Wilking, Bengt Jönsson
Section E Determinants of drug utilization
31 Health system perspectives 328 Paul Spivey, Brian Godman
32 Prescriber perspectives 336 Colin Bradley, Kathleen Holloway, Janet Krska
33 Patient perspectives 347 Janine Traulsen, Nicky Britten, Janet Krska
Section F Adherence and drug utilization research
34 An introduction to adherence research 355 Bernard Vrijens
35 Assessment of medication adherence in field research 361 Monique Elseviers, Bernard Vrijens
36 Assessment of adherence to drug treatment in database research 369 Jean-Pierre Grégoire, Jocelyne Moisan
37 Interventions to improve adherence to drug treatment 381 Marie-Paule Schneider, Jennifer Celio, Yoleen van Camp, Matthias Cavassini
Section G The role of drug utilization within the field of pharmacoepidemiology
38 Drug utilization research and risk management 392 Giampiero Mazzaglia, Peter Mol
39 Drug utilization research and pharmacovigilance 399 Emanuel Raschi, Fabrizio De Ponti
40 Drug utilization research and the regulator's perspective in pharmacovigilance 408 Xavier Kurz, Kevin Blake
41 Drug utilization research and outcomes research 417 Henrik Toft Sørensen, Gianluca Trifi rò
42 Drug utilization research and pharmacoeconomics 425 Cara Usher, Kathleen Bennett, Lorenzo G. Mantovani, Dyfrig Hughes
Section H Assessment and improvement of the quality of medicine use
43 Assessment of quality of prescribing using quality indicators 433 Petra Denig, Flora Haaijer-Ruskamp, Lisa Pont
44 Quality indicators for patient care in pharmacy practice 443 Hanne Herborg
45 Interventions that infl uence prescribing decisions and drug utilization 460 Jens Søndergaard, Dorte Gilså Hansen, Debra Rowett
46 Development, delivery and evaluation of implementation programmes 468 Elizabeth Roughead, Andrew Gilbert
47 Towards a better understanding of prescribingenhancement interventions 477 Frank May
Part 4 Epilogue
48 The many futures of drug utilization research 489 Hubert G.M. Leufkens, Frank May, Nicky Britten
Glossary 492
Index 497
List of contributors
Niels Adriaenssens
Centre for General Practice Department of Primary and Interdisciplinary Care (ELIZA) and
Laboratory of Medical Microbiology
Vaccine & Infectious Disease Institute (VAXINFECTIO)
University of Antwerp
Belgium
Anna Birna Almarsdóttir
Clinical Pharmacology
Institute of Public Health
University of Southern Denmark
Denmark
Morten Andersen
Centre for Pharmacoepidemiology
Department of Medicine
Karolinska Institutet
Sweden
and
Research Unit of General Practice
Department of Public Health
University of Southern Denmark
Denmark
Indranil Bagchi
Pfizer
United States
Nadia Barozzi
Healthy4Life
Basel
Switzerland
Pia Bastholm Rahmner
Medical Management Centre
Department of Learning, Informatics, Management and Ethics
Karolinska Institutet
Sweden
Ria Benko
Department of Clinical Pharmacy
Faculty of Pharmacy
University of Szeged
Hungary
Kathleen Bennett
National Centre for Pharmacoeconomics
St James's Hospital
Ireland
Marion Bennie
Institute of Pharmacy and Biomedical Sciences
University of Strathclyde
Scotland
and
Information Services Scotland,
NHS National Services Scotland, United Kingdom
Ulf Bergman
Department of Clinical Pharmacology
Karolinska Institutet
Karolinska University Hospital
Sweden
Kevin Blake
Best Evidence Development Service
Human Medicines Research and Development Support Division
European Medicines Agency
United Kingdom
Hege Salvesen Blix
WHO Collaborating Centre for Drug Statistics Methodology
Department of Pharmacoepidemiology
Norwegian Institute of Public Health
Norway
Colin Bradley
Department of General Practice
University College Cork
Ireland
Nicky Britten
University of Exeter Medical School
United Kingdom
Stephen Byrne
School of Pharmacy, University College Cork
Ireland
Stephen Campbell
Centre for Primary Care
Institute of Population Health
and
Patient Safety Translational Research Centre
Institute of Population Health
University of Manchester
United Kingdom
Matthias Cavassini
Service of Infectious Disease
Centre hospitalier universitaire vaudois
and
University of Lausanne
Switzerland
Jennifer Celio
Community Pharmacy
School of Pharmaceutical Sciences
Universities of Geneva, University of Lausanne
Switzerland
and
Community Pharmacy
Department of Ambulatory Care & Community Medicine
University of Lausanne
Switzerland
Samuel Coenen
Department of Epidemiology and Social Medicine (ESOC)
Department of Primary and Interdisciplinary Care (ELIZA) and
Vaccine & Infectious Disease Institute (VAXINFECTIO)
University of Antwerp
Belgium
Shane Cullinan
University College Cork
Ireland
Petra Denig
Clinical Pharmacy and Pharmacology
University of Groningen, University Medical Center Groningen
The Netherlands
Fabrizio De Ponti
Pharmacology Unit
Department of Medical and Surgical Sciences
University of Bologna
Italy
Mirko Di Martino
Department of Epidemiology
Lazio Regional Health Service, Roma
Italy
Monique Elseviers
Centre for Research and Innovation in Care
Faculty of Medicine and Health Sciences
University of Antwerp
Belgium
Irene Eriksson
Centre for Pharmacoepidemiology
Department of Medicine
Karolinska Institutet
Sweden
and
Department of Healthcare Development
Stockholm County Council
Sweden
Andrew Gilbert
School of Pharmacy and Medical Sciences
University of South Australia
Australia
Brian Godman
Department of Laboratory Medicine
Karolinska Institutet
Sweden
and
Strathclyde Institute of Pharmacy and
Biomedical Sciences, University of Strathclyde,
Glasgow, United Kingdom
Jean-Pierre Grégoire
Faculty of Pharmacy
Laval University
Canada
and
Population Health and Optimal Health Practices
Research Unit
CHU de Québec Research Centre
Canada
Flora Haaijer-Ruskamp
Clinical Pharmacy and Pharmacology
University of Groningen, University Medical Center Groningen
The Netherlands
Jesper Hallas
Clinical Pharmacology
Institute of Public Health
University of Southern Denmark
Denmark
Donald Han
Pfizer
United States
Dorte Gilså Hansen
Research Unit of General Practice
Institute of Public Health
University of Southern Denmark
Denmark
Hanne Herborg
Pharmakon
Danish College of Pharmacy Practice
Denmark
Mikael Hoffmann
The NEPI Foundation
Linköping University
Sweden
Thomas Hofmarcher
Department of Economics
Lund University
Sweden
Kathleen Holloway
World Health Organization Regional Office for South-East Asia
India
Dyfrig Hughes
Centre for Health Economics & Medicines Evaluation
Bangor University
United Kingdom
Vu Thi Thu Huong
Pharmacy Department, E Hospital, Hanoi, Vietnam and Administration Medical Services, Ministry of Health, Hanoi
Vietnam
Luisa Ibáñez
Foundation of the Catalan Institute of Pharmacology (FICF)
Spain
Saira Jan
Department of Clinical Pharmacy Management
Horizon Blue Cross Blue Shield of New Jersey
United States and
Clinical Professor
Rutgers State University of New Jersey, Piscataway
New Jersey
United States
Bengt Jönsson
Stockholm School of Economics
Sweden
Roberta Joppi
Pharmaceutical Drug Department
Azienda Sanitaria Locale of Verona
Italy
Maarit Jaana Korhonen
Department of Pharmacology
Drug Development and Therapeutics
University of Turku
Finland
Janet Krska
Medway School of Pharmacy
Universities of Greenwich and Kent
United Kingdom
Xavier Kurz
Pharmacovigilance Division
European Medicines Agency
United Kingdom
Hye Young Kwon
Institute of Health and Environment
Seoul National University
South Korea
Laurent Laforest
PharmacoEpidemiology Lyon (PEL),
HESPER Unit, Claude-Bernard University-Lyon1
France
Irene Langner
AOK Research Institute (WIdO)
Germany
Hubert G.M. Leufkens
Division of Pharmacoepidemiology and Clinical
Pharmacology
Utrecht Institute for Pharmaceutical Sciences
Utrecht University
The Netherlands
Tatiana Chama Borges Luz
René Rachou Research Center
Oswaldo Cruz Foundation
Brazil
Sean MacBride-Stewart
Prescribing and Pharmacy Support Unit
NHS Greater Glasgow and Clyde
United Kingdom
Lorenzo G. Mantovani
Department of Statistics
School of Medicine
University of Milano
Italy
Jaana E. Martikainen
Research Department
Social Insurance Institution (Kela)
Finland
Maria Matuz
Department of Clinical Pharmacy
Faculty of Pharmacy
University of Szeged
Hungary
Frank May
Drug and Therapeutics Information Service,
Repatriation General Hospital, Daw Park,
South Australia
School of Pharmacy, Faculty of Health and
Behavioural Sciences, University of Queensland,
Australia
Giampiero Mazzaglia
Scientific and Regulatory Management Department
Human Medicines Evaluation Division
European Medicines Agency
United Kingdom
Stuart McTaggart
National Health Service for Scotland
United Kingdom
Juan Merlo
Unit for Social Epidemiology
Faculty of Medicine
Lund University
Skåne University Hospital
Sweden
Jocelyne Moisan
Faculty of Pharmacy
Laval University
Canada
and
Population Health and Optimal Health Practices
Research Unit
CHU de Québec Research Centre
Canada
Peter Mol
Medicines Evaluation Board
The Netherlands
and
Department of Clinical Pharmacy and Pharmacology
University Medical Centre Groningen
University of Groningen
The Netherlands
Luigi Naldi
Unità Complessa di Dermatologia
Azienda Ospedaliera Papa Giovanni XXIII and Centro Studi GISED (Italian Group for Epidemiologic Research in Dermatology)
Italy
Martin Neovius
Clinical Epidemiology Unit Department of Medicine
Karolinska Institutet
Sweden
Antje Neubert
Department of Paediatric and Adolescent Medicine
University Hospital Erlangen
Germany
Evalill Nilsson
The Research and Development Department of Local Health Care
Östergötland Region
Sweden
Hedvig Nordeng
Pharmaco-Epidemiology and Drug Safety Research Group
School of Pharmacy
University of...
