Personalized Drug Screening for Functional Tumor Profiling
Published on 22. June 2022
978-1-009-03723-5 (ISBN)
Description
Despite considerable advances in our understanding of the biology that underlies tumor development and progression of cancer and the rapidly evolving field of personalized medicine, cancer is still one of the deadliest diseases. Many cancer patients have benefited from the survival improvements observed with targeted therapies but only a small subset of patients receiving targeted drugs experience an objective response. Because cancer is a complex and heterogeneous disease, the search for effective cancer treatments will need to address not only patient-specific molecular defects but also aspects of the tumor microenvironment. The functional tumor profiling directly measures the cellular phenotype, in particular tumor growth, in response to drugs using patient-derived tumor models and might be the next step toward precision oncology. In this Element, the authors discuss the personalized drug screening as a novel patient stratification strategy for the determination of individualized treatment choices in oncology.
More details
Series
Language
English
Place of publication
Cambridge
United Kingdom
Illustrations
Worked examples or Exercises
File size
1,70 MB
ISBN-13
978-1-009-03723-5 (9781009037235)
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Schweitzer Classification
Other editions
Additional editions
Victoria El-Khoury | Tatiana Michel | Hichul Kim
Personalized Drug Screening for Functional Tumor Profiling
Book
07/2022
Cambridge University Press
€24.00
Shipment within 15-20 days
Content
1. Rationale for functional profiling in oncology; 2. Tumor models in drug screening; 3. Cell-based screening platforms for personalized medicine; 4. Drug repurposing in personalized oncomedicine; 5. Clinical applications of drug screening in oncology; 6. Conclusions and perspectives; References.
