Structure-Function Relationships of Proteolytic Enzymes
Proceedings of the International Symposium, Copenhagen June 16-18, 1969, No. 37 in the Series of the International Union of Biochemistry Sponsored Symposia
Published on 10. May 2014
310 pages
978-1-4832-6117-1 (ISBN)
Description
Structure-Function Relationships of Proteolytic Enzymes provides information pertinent to the fundamental aspects of proteolytic enzymes. This book presents the historical role of proteolytic enzyme as a group in protein and enzyme chemistry. Organized into 23 chapters, this book begins with an overview of the results obtained from investigation on the chymotrypsinogens of porcine origin. This text then examines the differences of amino acid sequence between chymotrypsin, trypsin, and elastase that affect the substrate binding site, which reflect the specificity differences between these enzymes. Other chapters consider the kinetic parameters related to the trypsin-catalyzed hydrolysis of several model peptides. This book discusses as well the acetylation of trypsin, which result in functional consequences varying from complete inactivation to promotion of activity. The final chapter deals with the physical properties of stem bromelain in comparison with the data for three other sulfhydryl proteases of plant origin. This book is a valuable resource for enzymologists, microbiologists, and biochemists.
More details
Content
¿List of ParticipantsForewordSession I: Pancreatic Proteases On the Three Chymotrypsinogens of Porcine Pancreas Comments Comments Chymotrypsin: Tertiary Structure and Enzymatic Activity (Abstract) Comments Comments The Role of Carboxylates and Phenol Side-Chains in the Activity and Conformation of Trypsinogen, Trypsin, Chymotrypsinogen, and Chymotrypsin Chemical Modifications of Bovine Trypsinogen and Trypsin The Specificity Site of Trypsin Comments Structure and Mechanism of Action of a Pancreatic Trypsin Inhibitor The Chemistry of the Reactive Site of Soybean Trypsin Inhibitor Structural Aspects of Interaction of Trypsin with Macromolecular Inhibitors Homology and Phylogeny of Proteolytic Enzymes Comments Comments Structural Aspects of Thrombin and Prothrombin Cobalt Proteases: Implications of Absorption and Circular Dichroism Spectra for CatalysisSession II: Microbial Proteases Some Structure-Function Relationships in the Subtilisins Subtilisin BPN': Tertiary Structure and Inhibitor Binding (Abstract) Comments Subtilisin: Stability Properties and Secondary Binding Sites Comments Aminopeptidases from Thermophilic Microorganisms The Second Kaj Linderstrom-Lang Gold Medal Lecture A Synthetic Approach to the Study of Microenvironmental Effects on Enzyme ActionSession III: Pepsin and Related Enzymes Specificity and Mechanism of Pepsin Action Comments Towards a Mechanism for Pepsin Comments Comments Chemical Studies on Purified Pepsin Porcine Pepsinogen and Pepsin CommentsSession IV: Sulfhydryl Proteases The Three-Dimensional Structure of Papain Streptococcal Proteinase Structure and Function of Stem Bromelain
