Transduction Mechanisms in Cellular Signaling

Volume two includes 183 chapters divided in 8 sections, including: Section A: Protein Phosphorylation 56 Eukaryotic Kinomes: Genomics and Evolution of Protein Kinases 57 Modular Protein Interaction Domains in Cellular Communication 58 Structures of Serine/Threonine and Tyrosine Kinases 59 Protein Tyrosine Kinase Receptor Signaling Overview 60 Signaling by the Platelet-Derived Growth Factor Receptor Family 61 The Epidermal Growth Factor Receptor Family 62 Mechanisms and Functions of Eph Receptor Signaling 63 Cytokine Receptor Signaling 64 The Negative Regulation of JAK/STAT signaling 65 Protein Kinase Inhibitors 66 Integrin Signaling: Cell Migration, Proliferation, and Survival 67 Downstream Signaling Pathways: Modular Interactions 68 Non-Receptor Tyrosine Kinases in T Cell Antigen Receptor Function 69 Receptor Tyrosine Kinase Signaling and Ubiquitination 70 TGFb Signal Transduction 71 Mitogen-Activated Protein Kinases 72 Recognition of Phospho-Serine/Threonine Phosphorylated Proteins 73 AMP-Activated Protein Kinase 74 Principles of Kinase Regulation 75 Calcium/Calmodulin-Dependent Protein Kinase II 76 Glycogen Synthase Kinase 3 77 The PIKK Family of Protein Kinases 78 Histidine Kinases in Two-Component Signaling Pathways 79 The EF2K/MHCK/TRPM7 Family of Atypical Protein Kinases 80 The Leucine-Rich Repeat Receptor Protein Kinases of Arabidopsis thaliana 81 Engineering Protein Kinases with Specificity for Unnatural Nucleotides and Inhibitors 82 Clinical Applications of Kinase Inhibitors in Solid Tumors 83 Ubiquitin-Mediated Regulation of Protein Kinases in NF¿B Signaling 84 Global Analysis of Phosphoregulatory Networks Section B: Protein Dephosphorylation 85 Phosphatase Families Dephosphorylating Serine and Threonine Residues in Proteins 86 The Structure and Topology of Protein Serine/Threonine Phosphatases 87 Naturally Occurring Inhibitors of Protein Serine/Threonine Phosphatases 88 Protein Phosphatase 1 Binding Proteins 89 Protein Serine/Threonine Phosphatase Inhibitors and Human Disease 90 Calcineurin 91 Protein Serine/Threonine-Phosphatase 2C (PP2C) 92 Approaches to the Identification of Protein Tyrosine Phosphatase Substrates 93 Inhibitors of Protein Tyrosine Phosphatases 94 Regulating Receptor PTP Activity 95 CD45