Biochemical Correlates of Brain Structure and Function
Published on 2. December 2012
360 pages
978-0-323-15425-3 (ISBN)
Description
Biochemical Correlates of Brain Structure and Function deals with the biochemical correlates of brain structure and function, providing some examples of contemporary work interrelating structure with function of the nervous system. The developing brain provides a system for this kind of study, but broad correlates are also drawn between changing biochemistry and increasing physiological activity. This book is organized into nine chapters and begins with an overview of biochemical, morphological, and functional changes in the developing brain, as well as the underlying molecular basis of nerve differentiation and growth of the developing brain. An account of the concept of the cell cycle and its control is also given. The reader is methodically introduced to the properties of the developing retina and its functional biochemistry, with specific reference to the cyclic nucleotides; the use of selective lesioning to delineate GABA-ergic and cholinergic tracts as well as the catecholamine pathways; and cerebral blood flow alteration in concert with mental activity. The remaining chapters explore regions of the brain with altered glucose utilization in response to changes in local functional activity; the physiologically important factors regulating the supply of oxygen and glucose and the relation of metabolic rate to the metabolic state of the brain; and varying aspects of behavioral neurochemistry. This book is intended for chemists and biologists as well as students of biochemistry.
More details
Other editions
Additional editions
Alan Nelson Davison
Biochemical Correlates of Brain Structure and Function
Book
01/1977
Academic Press
€69.33
Article exhausted; check different version
Content
List of ContributorsPrefaceChapter 1 Biochemical, morphological and functional changes in the developing brain I. Introduction A. "The growth spurt" B. The developing brain ReferencesChapter 2 Regulation of ribonucleic acid metabolism in the developing brain I. Introduction II. Genera l scheme of the synthesis of messenger RNA and ribosomal RNA in animals III. Developmental changes in the metabolism of high molecular weight RNA in rat forebrain A. Nucleocytoplasmic relationships: synthesis and transport of RNA B. Processing of ribosomal RNA C. Characterization of brain polyadenylated RNA D. Progressive decrease in the synthesis of poly deny lated RNA E. Molecular weight distribution of polyadenylated RNA F. Content of poly (A) G. Interactions of ribosomal subunits and of mRNA on polyribosomes IV. Summary of changes in the nucleocytoplasmic relationship of high molecular RNA during development of rat forebrain V. The effects of amino acid imbalance on polyribosomes during the vulnerable period of their development VI. Concluding remarks including an hypothesis for the regulation of mRNA synthesis Acknowledgments ReferencesChapter 3 Metabolic influences on cell proliferation in the brain I. Introduction II. Brief outline of the histogenesis and morphogenesis of the vertebrate nervous system A. Early development B. Primary germinal sites C. Secondary germinal sites III. Influence of metabolic factors on cell proliferation A. Thyroid deficiency B. Effect of excess of thyroid hormone during infancy C. Effect of growth hormone D. Undernutrition IV. Drugs and cell proliferation in the brain A. Effect of reserpine B. Cyclic nucleotides, drugs affecting neurohumor receptors and cell proliferation ReferencesChapter 4 Cyclic nucleotides and neuronal function: cyclic-GMP-dependent photoreceptor degeneration in inherited retinal diseases I. Introduction II. Cyclic nucleotides in the central nervous system (CNS) A. Cyclic AMP B. Cyclic GMP C. Yin-Yang hypothesis III. Cyclic nucleotides and photoreceptor degeneration in the retina of C3H mice IV. Cyclic nucleotide metabolism and photoreceptor degeneration in the retina of RCS rats V. Cyclic AMP metabolism in the inner layers of the retina VI. Cyclic nucleotides and neurological disorders Acknowledgments ReferencesChapter 5 Neurotransmitter-related pathways: the structure and function of central monoamine neurones I. Introduction II. Monoamine pathways: histochemical techniques III. Catecholamine-containing neurones A. The dopamine systems B. The noradrenaline systems C. Adrenaline systems IV. 5-Hydroxytryptamine-containing neurones V. Monoamine systems in human brain VI. The ontogeny of monoamine systems VII. Functions of monoamine neurones A. Catecholamine systems B. Serotonergic systems VIII. Functions of monoamine neurones at the cellular level IX. Summary ReferencesChapter 6 Physiological aspects of brain energy metabolism I. Introduction II. Methods for blood flow and metabolism A. Blood flow and oxygen consumption B. Glucose consumption C. High energy phosphate utilization D. Fixation of tissue for metabolite analyses E. Species differences III. General coupling of function, metabolism and blood flow in neuronal systems IV. Conditions with a primary decrease in functional activity A. Barbiturate anesthesia B. Hypothermia V. Conditions with a primary increase in functional activity A. Epileptic seizures B. Hyperthermia C. Amphetamine intoxication D. Anxiety and stress VI.
