Current Topics in Membranes
Academic Press
Published on 17. December 1991
254 pages
978-0-08-058509-3 (ISBN)
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Current Topics in Membranes
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Joseph F. Hoffman | Gerhard H. Giebisch | Murdoch J. Ritchie
Current Topics in Membranes Vol. 38
Ordering the Membrane-Cytoskeleton Trilayer
Book
11/1991
Elsevier
€91.07
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Content
- Front Cover
- Ordering the Membrane-Cytoskeleton Trilayer
- Copyright Page
- Contents
- Contributors
- Foreword
- Preface
- Previous Volumes in Series
- Chapter 1. Molecular Genetic Analyses of Drosophila Kinesin
- I. Introduction
- II. Kinesin Structure
- III. Kinesin Function
- IV. Conclusion
- References
- Chapter 2. Acanthamoeba Myosin I: Past, Present, and Future
- I. Discovery
- II. Multiplicity of Isoforms
- III. Heavy Chain Sequences
- IV. Structural Basis of the Actin-Activated ATPase Activity
- V. Mechanochemical Properties and Their Structural Basis
- VI. Regulation
- VII. Intracellular Localization
- VIII. Concluding Remarks
- References
- Chapter 3. Structural and Functional Dissection of a Membrane-Bound Mechanoenzyme: Brush Border Myosin I
- I. Introduction: Is There a Superfamily of Myosin Genes?
- II. The Structural and Functional Properties of Brush Border Myosin I: An Overview
- III. Probing the Function of Brush Border Myosin I Calmodulin Light Chains
- IV. The Interaction of Brush Border Myosin I with the Microvillar Membrane
- V. Some Notions Regarding Brush Border Myosin I Function
- References
- Chapter 4. Protein Interactions Linking Actin to the Plasma Membrane in Focal Adhesions
- I. Introduction
- II. Interaction between a-Actinin and ß1 Integrin
- III. Interaction between Talin and Actin
- IV. Conclusion
- References
- Chapter 5. Ankyrins: A Family of Proteins That Link Diverse Membrane Proteins To the Spectrin Skeleton
- I. Introduction
- II. Ankyrin Structure
- III. Ankyrins Are a Multigene Family
- IV. Functional Diversity of Ankyrin due to Alternative Splicing of mRNA
- V. Mapping the Binding Sites of Ankyrin
- VI. Summary and Future Perspectives
- References
- Chapter 6. Contractile and Cytoskeletal Proteins in Drosophila Embryogenesis
- I. Introduction
- II. Movements of Early Embryogenesis
- III. Cell Shape Change Requires Remodeling of the Actin Cytoskeleton
- IV. Non-Muscle Myosins
- V. Spectrins
- VI. Summary
- References
- Chapter 7. Dominant Mutations of Cytoskeletal Proteins in Xenopus Embryos
- I. Introduction
- II. The Role of Membrane Skeleton Protein 4.1 during Embryogenesis
- III. Dissecting the Functions of Vimentin during Embryonic Development
- IV. Discussion
- References
- Chapter 8. The Animal Models of Duchenne Muscular Dystrophy: Windows on the Pathophysiological Consequences of Dystrophin Deficiency
- I. Introduction
- II. The Animal Models of Duchenne Dystrophy: Biochemical and Genetic Homology
- III. Human Duchenne Dystrophy: Progressive Histopathology Leading to Muscle Wasting
- IV. The mdx Mouse: Nonprogressive Histopathology Resulting in Hypertrophy
- V. The xmd Dog: Rapidly Progressive Histopathology Leading to Muscle Wasting
- VI. The Dystrophin-Deficient Cat: Semiprogressive Histopathology with No Loss of Muscle Fibers
- VII. Phase I. The Primary Cellular Consequence of Dystrophin Deficiency: Generalized Leakage of the Plasma Membrane Buffered by the Syncytial Cytoplasm?
- VIII. Phase I Conclusion: An Integrated Model Featuring Ca2+
- IX. Phase II: Progressive Pathology and Clinical Weakness Specific to Humans and Dogs
- X. The Development of Progressive Histopathology: Could Basic Fibroblast Growth Factor Have a Major Role?
- XI. Conclusion: An Integrated Model and Its Consequences on the Development of Therapeutics
- References
- Chapter 9. Mutant Cytoskeletal Proteins in Hemolytic Disease
- I. Introduction: Membrane/Skeleton Symposium
- II. Detection and Characterization of Spectrin Mutants in Hereditary Elliptocytosis
- III. Mutant Forms of Protein 4.1 in Hereditary Elliptocytosis
- IV. Hereditary Spherocytosis
- References
- Chapter 10. Dynamics of Intestinal Epithelial Tight Junctions
- I. Introduction
- II. Tight Junctions (Zonula Occludens) as Potentially Regulated Barriers
- III. Intestinal Zonula Occludens as a Regulated Transport Pathway
- IV. Intestinal Zonula Occludens Function in Model Disease States
- V. Conclusions
- References
- Chapter 11. Regulation of Actin and Myosin II Dynamics in Living Cells
- I. Introduction
- II. Quiescent Fibroblasts as a Model System
- III. The Multimode Approach
- IV. Actomyosin Dynamics in Serum-Starved 3T3 Fibroblasts
- V. Regulation of Stress Fiber Contraction
- VI. Stress Fiber Movement and Cell Motility
- VII. Some Future Prospects
- References
- Chapter 12. Expression and Function of Genetically Engineered Actin-Binding Proteins in Dictyostelium
- I. The Microfilament System of Dictyostelium discoideum
- II. F-Actin Cross-Linking Proteins in Dictyostelium discoideum
- III. Genetic Manipulation of a-Actinin in Escherichia coli and Dictyostelium discoideum
- References
- Chapter 13. Interaction of Profilins with Membrane Lipids
- I. Binding of Profilin to Phospholipids
- II. Profilin Inhibits Soluble Phospholipase C
- III. Interaction of Profilin with Actin
- IV. What Does Profilin Actually Do in a Cell?
- References
- Chapter 14. Polarized Assembly of Spectrin and Ankyrin in Epithelial Cells
- I. Introduction: The Red Cell Paradigm
- II. The Unexpected Spatial Polarization of the Nonerythroid Spectrin Cytoskeleton
- III. The Interaction of Spectrin and Ankyrin with Basolateral Na+/K+-ATPase
- IV. Does Polarized Membrane Skeletal Assembly Require Ankyrin?
- V. Models for the Role of the Nonerythroid Spectrin-Actin Cytoskeleton
- References
- Index
