Current Topics in Developmental Biology
Academic Press
Published on 24. July 1990
346 pages
978-0-08-058447-8 (ISBN)
Description
Current Topics in Developmental Biology
More details
Other editions
Additional editions
Marit Nilsen-Hamilton
Current Topics in Developmental Biology: Growth Factors and Development v. 24
Book
06/1990
Academic Press
€81.09
Article exhausted; check different version
Person
Content
- Cover
- Copyright Page
- TOC$Contents
- Contributors
- Preface
- Table of Abbreviations
- CH$Chapter 1. Developmental Activities of the Epidermal Growth Factor Receptor
- I. Introduction
- II. EGF-R Activity in Mammalian Development
- III. The EGF Gene and Its Product
- IV. The TGF-a Gene and Its Product
- V. Regulation of EGF-R Expression
- VI. EC Cell Model Systems
- VII. Summary
- References
- CH$Chapter 2. Epidermal Growth Factor and Transforming Growth Factor-a in the Development of Epithelial-Mesenchymal Organs of the Mouse
- I. Introduction
- II. Effects of Exogenous EGF on Morphogenesis and Differentiation
- III. Expression of EGF Receptors in Developing Organs
- IV. EGF and TGF-a in Epithelial-Mesenchymal Tissue Interactions
- V. Summary
- References
- CH$Chapter 3. Fibroblast Growth Factor and Its Involvement in Developmental Processes
- I. Introduction
- II. Molecular Characterization of the FGF Genes, mRNA, and Protein Products
- III. Mesoderm Induction in Early Embryos
- IV. Muscle Formation in Early Embryos
- V. Development of the Nervous System
- VI. Possible Role of FGF in Cartilage and Bone Formation
- VII. Limb Regeneration
- VIII. Ovarian Follicular Morphogenesis
- IX. Vascular Development
- X. The Extracellular Matrix
- XI. Wound Healing
- XII. Carcinogenic Transformation
- XIII. Conclusions
- References
- CH$Chapter 4. Transforming Growth Factor-ß and Its Actions on Cellular Growth and Differentiation
- I. Transforming Growth Factor-ß and Its Many Forms and Diverse Functions
- II. Synthesis and Properties of TGF-ß
- III. Receptors for TGF-ß
- IV. Effects of TGF-ß at the Molecular Level
- V. Effects of TGF-B at the Cellular Level
- VI. TGF-ß in Vivo
- VII. The TGF-ß Family in Development
- VIII. Summary and Conclusions
- References
- CH$Chapter 5. The Insulin Family of Peptides in Early Mammalian Development
- I. Introduction
- II. Structure and Function of IGFs and Insulin
- III. Structure and Function of IGF and Insulin Receptors
- IV. Preimplantation Embryos
- V. Postimplantation Embryos
- VI. Discussion
- References
- CH$Chapter 6. Nerve Growth Factor and the Issue of Mitosis in the Nervous System
- I. Introduction
- II. NGF and the Nervous System
- III. Discovery of NGF: A Brief History
- IV. NGF and the Peripheral Nervous System
- V. NGF and the Central Nervous System
- VI. NGF and Early Studies of Neuronal Precursor Proliferation
- VII. Unique Nervous System Characteristics Require Novel Experimental Approaches
- VIII. Identified Neuroblasts Divide in Culture
- IX. Insulin Regulates the Neuroblast Mitotic Cycle
- X. NGF Does Not Regulate the Mitotic Cycle of Cultured Neuroblasts
- XI. IGF-I Is a Highly Potent Neuronal Mitogen
- XII. Multiple Factors May Interact to Regulate Neuroblast Mitosis
- XIII. Prospects
- References
- CH$Chapter 7. Developmental Roles for Growth Factor-Regulated Secreted Proteins
- I. Introduction
- II. Mitogen-Regulated Protein
- III. PLs and Other Prolactinlike Polypeptides
- IV. Cathepsin L
- V. Proteins of the ECM
- VI. Conclusions
- References
- CH$Chapter 8. Growth Factor-Regulated Proteases and Extracellular Matrix Remodeling during Mammalian Development
- I. Growth Factors and Extracellular Matrix in Development
- II. Growth Factor-Regulated Proteases and Their Inhibitors
- III. Regulation of ECM, Proteases, and Inhibitors in Specific Developmental Systems by Growth Factors
- IV. Summary and Conclusions
- References
- CH$Chapter 9. The Role of Growth Factors in Embryonic Induction in Amphibians
- I. Introduction
- II. Summary of Amphibian Embryogenesis
- III. Use of Molecular Markers in Induction Studies
- IV. Embryonic Induction
- V. Mesoderm Induction Factors: Relationship to Growth Factors
- VI. Uses of XTC-MIF and FGF in Studying Mechanisms of Induction
- VII. Dorsalization versus Mesodermalization
- VIII. Neural Induction: Few Insights into Mechanism
- IX. Outlook on Research in Embryonic Induction
- X. Conclusion
- References
- CH$Chapter 10. Homologs of Vertebrate Growth Factors in Drosophila melanogaster and Other Invertebrates
- I. Introduction
- II. Loci That Encode Proteins Homologous to EGF
- III. decapentaplegic, A Locus That Encodes a Homolog of TGF-ß
- IV. wingless, A Locus That Encodes a Homolog of Murine int-1
- V. Summary
- References
- IDX$Index
