Current Topics in Developmental Biology
Academic Press
Published on 3. February 1986
432 pages
978-0-08-058443-0 (ISBN)
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Current Topics in Developmental Biology
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A.A. Moscona | A. Monroy
Current Topics in Developmental Biology: v.20
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02/1986
Academic Press
€107.88
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Content
- Front Cover
- Current Topics in Developmental Biology, Volume 20
- Copyright Page
- CONTENTS
- Contributors
- Foreword
- Preface
- Introduction: Can Specialized Cells Change Their Phenotype?
- Acknowledgments
- CHAPTER 1. Conversion of Retina Glia Cells into Lenslike Phenotype Following Disruption of Normal Cell Contacts
- I. Introduction
- ll. Keratogenesis in the Chorioallantoic Membrane
- lll. Modification of Retina Cells into Lenslike Phenotype
- References
- CHAPTER 2. Instability in Cell Commitment of Vertebrate Pigmented Epithelial Cells and Their Transdifferentiation into Lens Cells
- I. Introduction
- ll. Stable Differentiated State of Pigmented Epithelial Cells (PECs)
- lll. Transdifferentiation of PECs in Vitro
- IV. Dedifferentiated State of Chick Embryo PECs
- V. Gene Expression in the Process of Transdifferentiation
- VI. Concluding Remarks
- References
- CHAPTER 3. Transdifferentiation of Skeletal Muscle into Cartilage: Transformation or Differentiation?
- I. Introduction
- ll. Skeletal Muscle Differentiation
- lll. Formation of Cartilage by Skeletal Muscle
- IV. Skeletal Muscle Differentiation and Relationship to Satellite Cells
- V. Synthesis of Cartilage Extracellular Matrix
- VI. Origin of the Stimulus to Form Cartilage
- VII. Conclusions
- References
- CHAPTER 4. Transdifferentiated Hepatocytes in Rat Pancreas
- I. Introduction
- ll. Induction of Pancreatic Hepatocytes in Rats
- lll. Morphology of Pancreatic Hepatocytes
- IV. Induction of Peroxisome Proliferation in Pancreatic Hepatocytes
- V. Stability of Pancreatic Hepatocytes
- VI. Histogenesis of Pancreatic Hepatocytes
- VII. Concluding Remarks
- References
- CHAPTER 5. Transdifferentiation of Amphibian Chromatophores
- I. Introduction
- ll. Stability of Cell Commitment in Cultured Melanophores
- lll. Transdifferentiation from Iridophores into Melanophoresin in Clonal Culture
- IV. Transdifferentiation from Xanthophores into Melanophores in Clonal Culture
- V. Proliferation of lridophores without Transdifferentiation into Melanophores
- VI. Reflecting Platelet Formation in Cultured Melanophores
- VII.Concluding Remarks: Conversion between Different Chromatophore Types
- References
- CHAPTER 6. Multipotentiality in Differentiation of the Pineal as Revealed by Cell Culture
- I. Introduction
- ll. "Oculopotency" in Pineal Cells
- lll. Myogenic Potency in Pineal Cells
- IV. Repertoire of Differentiation of Pineals
- References
- CHAPTER 7. Transdifferentiation of Endocrine Chromaffin Cells into Neuronal Cells
- I. Introduction
- ll. Transdifferentiation of Adrenal Chromaffin Cells in Culture
- lll. Transdifferentiation of Adrenal Chromafin Cells in Situ and in Ectopic Sites
- IV. Concluding Remarks
- References
- CHAPTER 8. Neural Crest and Thymic Myoid Cells
- I. Introduction
- ll. Hypotheses on the Origin of Thymic Myoid Cells (TMC)
- lll. Neural Crest and Thymus
- IV. Interspecific Transplantation
- References
- CHAPTER 9. The Potential for Transdifferentiation of Differentiated Medusa Tissues in Vitro
- I. Introduction
- ll. The Isolation of Medusa Tissues
- lll. The Potential for Transdifferentiation
- IV. The Role of Cell Cycles
- V. Concluding Remarks
- References
- CHAPTER 10. The Presence of Extralenticular Crystallins and Its Relationship with Transdifferentation to Lens
- I. Introduction
- ll. Crystallin RNAs in Retina and Other Nonlens Tissues
- lll. Detection of d-Crystallin RNA by in Situ Hybridization
- IV. Noncoordinate Regulation of Crystallin RNAs during Transdifferentiation
- V. Evolutionary Considerations
- VI. Regulation of d-Crystallin Gene Expression: Concluding Remarks
- References
- CHAPTER 11. Dual Regulation of Expression of Exogenous d-Crystallin Gene in Mammalian Cells: A Search for Molecular Background of Instability in Differentiation
- I. Introduction
- ll. The Experimental System
- lll. Dual Regulation of d-Crystallin Gene
- IV. Expression of Exogenous d-Crystallin Gene in various Cell Types
- V. Correspondence to the Natural Situation
- VI. Concluding Remarks
- References
- CHAPTER 12. Neurotransmitter Phenotypic Plasticity in the Mammalian Embryo
- I. Introduction
- ll. Transient Expression of Neurotransmitter Phenotype during Normal Development
- lll. Factors Affecting Neurotransmitter Phenotype
- IV. Concluding Remarks
- References
- CHAPTER 13. Development of Neuronal Properties in Neural Crest Cells Cultured in Vitro
- I. Introduction
- ll. Emergence of Cholinergic and Adrenergic Phenotypes in Explanted Neural Crest Cells
- lll. Influence of Environment on Autonomic Differentiation in Cultured Neural Crest Cells
- IV. Plasticity of Neurotransmitter Expression in Developing Peripheral Ganglia
- V. Concluding Remarks
- References
- CHAPTER 14. Phenotypic Diversification in Neural Crest-Derived Cells: The Time and Stability of Commitment during Early Development
- I. Introduction: Cellular Metaplasia Provides an Opportunity to Analyze Phenotypic Stability and Commitment
- ll. The Neural Crest Gives Rise to Diverse Cellular Phenotypes during Embryonic Development
- lll. Neural Crest Cells Undergo a Progressive Series of Developmental Restrictions
- IV. Environmental Modulation of Phenotype in Cultured Crest-Derived Cells Probably Does Not Cause Qualitative Changesin Gene Regulation
- V. Metaplasia by Neural Crest-Derived Cells May Be Useful for Understanding Progressive Developmental Restrictions
- References
- CHAPTER 15. On Neuronal and Glial Differentiation of a Pluripotent Stem Cell Line, RT4-AC: A Branch Determination
- I. Introduction
- ll. Dual or Precocious Expression of Neuronal and Glial Properties in the Stem Cell Type, RT4-AC
- lll. Cell Type Conversion and Coordinate Gene Expression
- IV. Cell Type Conversion of RT4-AC and Enhancement of Gene Expression
- V. Maturational Expression of Genes That Are Not Closed by Cell Type Conversion (or Branch Determination)
- VI. The RT4 System Supports the Notion That the Tumor Has Originated from a Single Neural Stem Cell
- VII. Concluding Remarks
- References
- CHAPTER 16. Transitory Differentiation of Matrix Cells and Its Functional Role in the Morphogenesis of the Developing Vertebrate CNS
- I. Introduction
- ll.Matrix Cells and their proliferation Kinetics
- lll.Major vs Minor Differentiation of Matrix Cells
- IV. Progression of the Major Differentiation in Matrix Cells
- V. Intermediate Filaments as Markers of Cell Differentiation in the Developing CNS
- VI. Bundle Formation of Matrix Cells at Stage II and Its Function in Corticogenesis of the Vertebrate CNS
- VII. Transitory Expression of the Matrix Cell Abnormality in the Reeler Mutation
- VIII. Concluding Remarks
- References
- CHAPTER 17. Prestalk and Prespore Differentiation During Development of Dictyostelium Discoideum
- I. Introduction
- ll. Prestalk and Prespore Cells
- lll. Regulation of Prestalk/Prespore Differentiation
- IV. Differentiation Patterns of Prestalk/Prespore Cells
- V. Prestalk/Prespore Differentiation Tendencies
- VI. Reproductive Strategy of Cell Differentiation
- VII. Concluding Remarks
- References
- CHAPTER 18. Transdifferentiation Occurs Continuously In Adult Hydra
- I. Introduction
- ll. Growth Dynamics
- lll. Epitheliomuscular Cells
- IV. The Nervous System
- V. Conclusion
- References
- CHAPTER 19. Nematocyte Differentiation in Hydra
- I. Introduction
- ll. Position-Dependent Nematocyte Differentiation
- lll. The Instability of Commitment to Nematocytes
- IV. Summary
- References
- CHAPTER 20. The Microenvironment of T And B Lymphocyte Differentiation in Avian Embryos
- I. Introduction
- ll. Cellular Composition of the Early Thymic and Bursa1 Primordia
- lll. The Origin of Lymphocytes in Thymus and Bursa of Fabricius
- IV. The Role of the Bursa of Fabricius in B Lymphocyte Production
- V. Mechanisms of the Seeding of the Primary Lymphoid Organs by Hemopoietic Cells
- VI. Expression of Class II Antigens of the Major Histocompatibility Complex in the Thymus as Studied by the Quail-Chick System
- VII. Concluding Remarks
- References
- CHAPTER 21. Differential Commitment of Hemopoietic Stem Cells Localized in Distinct Compartments of Early Xenopus Embryos
- I. Introduction
- ll. Interstitial Immigration of Lymphoid Stem Cells in Early Thymus Rudiments
- lll. Localization of Hemopoietic Stem Cells in Embryos
- IV. Differential Commitment of VBI and DLP Mesoderms as Hemopoietic Stem Cells
- V. Concluding Remarks
- References
- CHAPTER 22. Probable Dedifferentiation of Mast Cells in Mouse Connective Tissues
- I. Introduction
- ll. Useful Mutant Mice
- lll. In Vitro Cultures
- IV. Differentiation Process
- V. Probable Dedifferentiation
- References
- CHAPTER 23. Instability and Stabilization in Melanoma Cell Differentiation
- I. Introduction: Cell Types
- ll. Commitment in Mouse Melanoma and Other Pigment Cells
- Ill. Perspectives
- IV. Concluding Remarks
- References
- CHAPTER 24. Differentiation of Embryonal Carcinoma Cells: Commitment, Reversibility, and Refractoriness
- I. Introduction
- ll. Criteria for Assessing Differentiation of EC Cells
- lll. Commitment of EC Cells
- IV. Is Differentiation of EC Cells Reversible?
- V. Refractoriness to Induction of Differentiation
- References
- CHAPTER 25. Embryo-Derived Stem Cells: A Tool for Elucidating the Developmental Genetics of the Mouse
- I. Introduction
- ll. Embryo-Derived Stem Cells in Vitro
- lll. Cultured Embryo-Derived Stem Cells in Chimeras in Vivo
- IV. Cultured Stem Cells: A Route into the Mouse Genome
- V. Concluding Remarks
- References
- CHAPTER 26. Phenotypic Stability and Variation in Plants
- I. Introduction
- ll. Phenotypic Stability
- lll. Phenotypic Variation
- IV. Cellular Basis for Stable Variation
- V. Concluding Remarks
- References
- CHAPTER 27. Flexibility and Commitment in Plant Cells during Development
- I. Introduction
- ll. Definitions of Commitment and Flexibility
- lll. Flexibility and Determination in Cultured Plant Cells
- IV. Commitment and Flexibility in the Whole Plant
- V. Competence for Cell Separation-Committed Cells in Abscission Zones
- VI. Cell Flexibility in Mature Plant Tissues
- VII. Concluding Remarks
- References
- CHAPTER 28. Induction of Embryogenesis and Regulation of the Developmental Pathway in Immature Pollen of Nicotiana Species
- I. Introduction
- ll. Factors That Enhance the Embryogenic Response in an Early Period of Anther Culture
- lll. Conditions That Can Modify the Commitment of Isolated Immature Pollen Grains in the Developmental Program
- References
- CHAPTER 29. Instability of Chromosomes and Alkaloid Content in Cell Lines Derived from Single Protoplasts of Cultured Coptis japonica Cells
- I. Introduction
- ll. Chromosome Instability
- lll. Instability of Berberine Production
- IV. Concluding Remarks
- References
- Index
