Current Topics in Developmental Biology
Academic Press
Published on 19. September 1980
375 pages
978-0-08-058437-9 (ISBN)
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Current Topics in Developmental Biology
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01/1980
Academic Press
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Content
- Front Cover
- Immunological Approaches to Embryonic Development and Differentiation
- Copyright Page
- Contents
- List of Contributors
- Preface
- Chapter 1. The Use of Monoclonal Antibody Techniques in the Study of Developing Cell Surfaces
- I. Introduction
- II. The Hybrid Myeloma Technique and the Production and Use of Monoclonal Antibodies
- III. Use of Monoclonal Antibodies to Define Differentiation Antigens of Cells of the Immune System and to Characterize Their Subsets
- IV. Other Systems
- V. Future Prospects
- VI. Concluding Remarks
- References
- Chapter 2. Early Stages of Lymphocyte Development
- I. Organization of the Lymphoid System: Overview
- II. Hemopoiesis: Definitions and Basic Considerations
- III. Hemopoietic Stem Cells
- IV. Thymocyte Progenitor Cells
- V. Thymocytopoiesis
- VI. Concluding Remarks
- References
- Chapter 3. Somatic Cell Genetics and the Development of the Immune System
- I. The Major Components of the Immune System
- II. Somatic Cell Genetics
- III. Applications of Somatic Cell Genetics to the Analysis of the Immune System
- IV. Concluding Remarks
- References
- Chapter 4. Complete Primary Structure of Human Histocompatibility Antigen HLA-B7: Evolutionary and Functional Implications
- I. Introduction
- II. Purification of HLA-A and -B Antigens after Papain Solubilization
- III. Dissection of the Papain-Solubilized Heavy Chain into Three Regions by Chemical Cleavages
- IV. Complete Primary Sequence of Papain-Solubilized HLA-B7
- V. Sequence Homology to Immunoglobulin Sequences
- VI. Purification of HLA-A and -B Antigens after Detergent Solubilization
- VII. Structure of the Penultimate Hydrophobic and C-Terminal Hydrophilic Peptides
- VIII. Use of HLA-A and -B Antigens Reconstituted in Liposomes to Study Function
- IX. Concluding Remarks
- References
- Chapter 5. Aspects of Surface Membrane Differentiation during Maturation of Human Hematopoietic and Tumor Cells: The La System
- I. Demonstration of Ia on Leukemic Granulocyte Membrane
- II. Occurrence of Ia Determinants on Myeloid Cells from Normal Bone Marrow
- III. Expression of Receptors for Complement and IgG Fc
- IV. Presence of Ia on Megakaryocytes
- V. Ia Expression on Hematopoietic Progenitor Cells
- VI. Presence of Ia on Certain Cultured Malignant Melanoma Cells
- VII. Concluding Remarks
- References
- Chapter 6. The ABH Blood Groups and Development
- I. Introduction
- II . The ABH Substances
- III . The Distribution of the ABH Antigens in the Body
- IV . Function and Biological Significance of ABH Antigend/Substances
- V . The ABH Antigens in Feto-Maternal Relationships
- VI . Concluding Remarks
- References
- Chapter 7. Cell-Mediated Immune Responses to Mouse Embryonic Cells: Detection and Characterization of Embryonic
- I . Introduction
- II . Some Cell Surface Antigens of Early Mouse Embryos
- III . Cell-Mediated Immune Responses to Early Mouse Embryos
- IV . Concluding Remarks
- References
- Chapter 8 . Immunological Methods in the Study of Chondroitin Sulfate Proteoglycans
- I . Introduction
- II . Structure of Proteoglycans
- III . Antigenicity of Proteoglycans
- IV . Concluding Remarks
- References
- Chapter 9 . ImmunologicaI Studies on Collagen Type Transition in Chondrogenesis
- I . Introduction
- II . Biochemistry and Immunochemistry of Collagen Types
- III. Collagen Type Transition during Chondrogenesis of Limb Bud Mesenchyme in Viuo
- IV .Collagen Type Transition during Chondrogenesis of Limb Bud Mesenchyme in Vitro
- V . Transition of Collagen Types in Chondrocyte Cultures
- VI. Collagen Type Transition during Cartilage- Bone Metamorphosis
- VII. Immunological Studies on Ectopic Cartilage Formation
- VIII. Conclusions
- References
- Chapter 10. The Application of Labeled Lectins and Antibodies to SDS Gels and Their Use in Studying Glycoproteins and Cell Surface Antigens during Development
- I. Introduction
- II. Principles of the Technique
- III. Changes in the Glycoproteins of Dictyostelium discoideum during Its Life Cycle
- IV. Glycoprotein Changes during Myogenesis
- V. Concluding Remarks.
- References
- Chapter 11. Univalent Antibody Fragments as Tools for the Analysis of Cell Interactions in Dictyostelium
- I. Introduction
- II. Membrane Changes during Development of Dictyostelium discoideum
- III. Analysis of Cell Adhesion by Fab
- IV. General Outlook on the Applicability of Univalent Antibodies in Developmental Biology
- V. Concluding Remarks
- References
- Chapter 12. Techniques for Localizing Contractile Proteins with Fluorescent Antibodies
- I. Introduction
- II. Preparation of Antisera
- III. Characterization of Antisera
- IV. Specimen Preparation
- V. Staining Methods
- VI. Staining Controls
- VII. Double Antibody Staining
- VIII. Concluding Remarks
- References
- Chapter 13. Antiserum to Myosin and Its Use in Studying Myosin Synthesis and Accumulation during Myogenesis
- I. Introduction
- II. Myosin Structure, Immunology, and Polymorphism
- III. Terminal Differentiation of Skeletal Muscle in Vitro
- IV. Antimyosin Applied to Detection of Myosin Synthesis during Myogenesis in Vitro
- V. Antimyosin in the Detection of MHC mRNA during Development
- References
- Chapter 14. Immunological Approaches to the Study of Myogenesis and Lens Fiber Junction Formation
- I. Introduction
- II. Immunological Approaches to the Study of Muscle Development
- III. Immunological Approaches to the Study of Intercellular Communication
- IV. Concluding Remarks
- References
- Chapter 15. Immunology and Developmental Biology: Summary and Concluding Remarks
- I. The Immune System
- II. Somatic Cell Genetics
- III. Intracellular Proteins
- IV. Embryonic Cell Surface: Invertebrates
- V. Embryonic Cell Surface: Vertebrates
- VI. Fibronectin and the Extracellular Matrix
- VII. The Lymphocyte as a Model for Ontogeny
- References
- Subject Index
- Contents of Previous Volumes
