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Sleep and the Maturing Nervous System contains manuscripts presented at a conference on Sleep and the Maturing Nervous Systems, held at the Allenberry Inn in Boiling Springs, Pennsylvania on June 21-24, 1970. The program is divided into five sessions: The Maturation of Neural Elements; Neurochemical Factors in Maturation of Sleep Behavior; Development of EEG and Activity Patterns in Relation to Sleep; Development of Reflex Patterns in Sleep; and Developmental Aspects of Normal and Abnormal Sleep Behavior. Organized into 19 chapters, the book begins by discussing the ontogenetic studies ranging from analyses of excitability properties and synaptic processes in single immature cortical neurons to structure-function correlations in developing cortical neuronal subsystems. This is followed by significant topics on the mutual relevancy between brain maturation and the ontogeny of sleep-wakefulness behavior. Additional aspects of the book focus on the developmental implications of conditions that might lead to the establishment of normal and abnormal sleep behavior in maturing organisms. A discussion on the problem of the mechanisms that underlie the unique distribution of behavior states at any particular age and during any particular experimental manipulation is provided along with a comparison of sleep behavior features between normal and mentally retarded subjects of the same age. This book will be of value to researchers and scientists interested in both the genetic and environmental factors determining the brain maturation and its relevancy in sleep and wakefulness.
Language
Place of publication
Publishing group
Elsevier Science & Techn.
ISBN-13
978-0-323-14835-1 (9780323148351)
Schweitzer Classification
List of ParticipantsPrefaceThe Maturation of Neural Elements 1 Principles of Synaptogenesis and Their Application to Ontogenetic Studies of Mammalian Cerebral Cortex Comparative Neuronal Morphogenesis and Synaptogenesis in Immature Cerebral Cortex: Functional Implications Excitability Properties of Dendrites of Immature Cortical Neurons Correlation Synaptogenesis and Evoked Potentials of Immature Cerebral Cortex Comments References 2 The Development of Synapses in the Rat Cerebellar Cortex Text References Invited Discussion (Chapter 1 and 2) by Guenter H. Rose References General Discussion (Chapter 1 and 2) References 3 Maturing Neuronal Subsystems: The Dendrites of Spinal Motorneurons Techniques Results Discussion Conclusion References Invited Discussion by Paul D. Coleman References General Discussion ReferencesNeurochemical Factors in the Maturation of Sleep Behavior 4 Coordination between Excitation and Inhibition: Development of the GABA System Introduction Cerebellum The GABA System in the Cerebellum of the Developing Chick GABA in Other Vertebrate Neuronal Systems Comment References General Discussion 5 Contributions of Differential Housing to Brain Development: Some Implications for Sleep Behavior Text References General Discussion 6 The Role of Biogenic Amines in Sleep Text References General Discussion References 7 Developmental Changes in Neurochemistry during the Maturation of Sleep Behavior Text References General Discussion References 8 Maturation of Neurobiochemical Systems Related to the Ontogeny of Sleep Behavior Text ReferencesDevelopment of EEG and Activity Patterns in Relation to Sleep 9 Development of Wakefulness-Sleep Cycles and Associated EEG Patterns in Mammals Interspecies Similarities Interspecies Differences References 10 The Basic Rest-Activity Cycle and Sleep: Developmental Considerations in Man and Cats Text Discussion References 11 Development of States in Infants Components of State Development of State Variables Development of Sleep States Sleep and Waking States Animal Studies Conclusions References Invited Discussion: by Nathaniel Kleitman Reference Invited Discussion by David R. Metcalf References General Discussion ReferencesDevelopment of Reflex Patterns in Sleep 12 The Somatosensory Cerebral Evoked Potentials of the Sleeping Human Newborn Immaturity of the Human Brain at Birth Evoked Potentials in REMS and SWS Comparison with Vertex Responses Amplitude of Evoked Potentials in Sleep States The Effect of Intervals Between Stimuli Conclusions and Summary References Invited Discussion by Mortimer G. Rosen References General Discussion 13 Patterns of Reflex Excitability during the Ontogenesis of Sleep and Wakefulness Introduction Brain Stem Reflex Activity in the Kitten Discussion References Invited Discussion by Dennis J.