Calcium and Cell Function

ContributorsPrefaceContents of Previous VolumesChapter 1 A Novel Cellular Signaling System Based on the Integration of Phospholipid and Calcium Metabolism I. Introduction II. Agonist-Dependent Phospholipid Metabolism III. Role of Calcium in Regulating Phospholipid Metabolism IV. The Role of Agonist-Dependent Phospholipid Metabolism V. Conclusion ReferencesChapter 2 The Transport of Calcium by Sarcoplasmic Reticulum I. Introduction II. Structure of Membranes Participating in Excitation-Contraction Coupling III. Protein Composition of Sarcoplasmic Reticulum IV. Lipids of Sarcoplasmic Reticulum V. Mechanism of ATP Hydrolysis and Ca2+ Transport VI. Protein-Protein Interactions in Sarcoplasmic Reticulum VII. Permeability of Sarcoplasmic Reticulum VIII. Relationship between Membrane Potential and Calcium Transport by the Sarcoplasmic Reticulum IX. Transport of Calcium by Cardiac Sarcoplasmic Reticulum X. Sarcoplasmic Reticulum in Fast-Twitch and Slow-Twitch Skeletal Muscles XI. Biosynthesis of Sarcoplasmic Reticulum XII. Sarcoplasmic Reticulum in Diseased Muscle ReferencesChapter 3 The Energetics and Chemistry for Interactions between Calmodulin and Calmodulin-Binding Proteins I. Chemistry of Calmodulin Interactions with Calmodulin-Binding Proteins II. Energetics of Calmodulin Binding to Calmodulin-Binding Proteins References Chapter 4 Specificity of Trifluoperazine and Related Phenothiazines for Calcium-Binding Proteins I. Introduction II. Mode of Binding of Phenothiazines to Calmodulin III. Selectivity of Calmodulin for Phenothiazines and Related Antipsychotic Agents IV. Site of Action of Phenothiazines as Calmodulin Antagonists V. Selectivity of Phenothiazines for Calmodulin VI. Other Effects of Phenothiazines VII. Conclusions References Chapter 5 Structure, Function, and Regulation of Phosphorylase Kinase I. Historical Background II. Purification III. General Structure IV. Structure and Function of the Subunits V. Phosphorylase Kinase from Other Sources ReferencesChapter 6 Regulation of Glycogen Synthase by Multiple Protein Kinases I. Introduction II. Glycogen Synthase Structure III. Phosphorylation by Specific Kinases in Vitro IV. Relationship of Synthase Activity to Phosphorylation State V. Glycogen Synthase Phosphatase VI. Hormonal Regulation of Synthase ReferencesChapter 7 Actomyosin of Smooth Muscle I. Introduction II. Contractile Apparatus III. Regulation of Contractile Activity IV. Evidence for and against the Phosphorylation Theory V. Summary of the Regulatory Process in Smooth Muscle ReferencesChapter 8 Calmodulin in Synaptic Function and Neurosecretion I. Introduction II. Synaptic Calmodulin III. Calmodulin and Ca2+-Dependent Neurotransmitter Release IV. Ca2+-Calmodulin-Stimulated Synaptic Protein Phosphorylation V. Evidence Suggesting That Synaptic Ca2+ and Calmodulin-Stimulated Protein Phosphorylation Mediates Ca2+-Dependent Neurotransmitter Release VI. Ca2+-Calmodulin Synaptic Vesicle and Synaptic Membrane Interactions VII. Ca2+-Calmodulin Tubulin Kinase System in Synaptic Modulation VIII. A Molecular Approach to Neurotransmission ReferencesChapter 9 Stimulation of Synthesis of Neurotransmitters by Calmodulin-Dependent Phosphorylation I. Introduction II. Activation of Tryptophan Hydroxylase by a Calmodulin-Dependent Phosphorylation Reaction III. Possible Role for Calmodulin in the Activation of Tyrosine Hydroxylase by Phosphorylating Conditions IV. Existence of Ca2+-Calmodulin-Dependent Tryptophan or Tyrosine Hydroxylase Kinase in Brain V. Summary ReferencesChapter 10 The Role of Calcium in Axoplasmic Transport in Nerve I. Properties of Axoplasmic Transport II. Dependence of Transport on Ca2+ III.