Integrins
Published on 27. August 2007
613 pages
978-0-08-055138-8 (ISBN)
Description
An integrin, or integrin receptor, is an integral membrane protein in the plasma membrane of cells. It plays a role in the attachment of a cell to the extracellular matrix (ECM) and to other cells, and in signal transduction from the ECM to the cell. There are many types of integrin, and many cells have multiple types on their surface. Integrins are of vital importance to all metazoans, from humans to sponges. This volume in Methods in Enzymology presents methods for studying integrins.
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Series
Edition
New ed.
Language
English
Place of publication
San Diego
United States
Product notice
Windows
Illustrations
Approx. 100 illustrations (50 in full color)
ISBN-13
978-0-08-055138-8 (9780080551388)
Copyright in bibliographic data and cover images is held by Nielsen Book Services Limited or by the publishers or by their respective licensors: all rights reserved.
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Content
Chapter 1: Quantitative Measurements of Integrin-Mediated Adhesion to Extracellular MatrixChapter 2: Investigating Integrin regulation and signaling events in three dimensional systemsChapter 3: Integrins in Cell MigrationChapter 4: Imtegrin Cytoskeletal InteracionsChapter 5: Cell Survival in a 3D MatrixChapter 6: Platelet Integrin Adhesive Functions and SignalingChapter 7: Development of Monoclonal Antibodies to Integrin ReceptorsChapter 8: Cell adhesion, cellular tension, and cell cycle controlChapter 9: Analysis of Integrin Signaling by Fluorescence Resonance Energy TransferChapter 10: Studies on integrins in the nervous systemChapter 11: Methods for identifying novel integrin ligandsChapter 12: Analysis of integrin functions in peri-implantation embryos, hematopoietic system and skinChapter 13: Identification and molecular characterization of multiple phenotypes in integrin knockout miceChapter 14: Purification, Analysis and Crystal Structure of IntegrinsChapter 15: Electron Microscopy of IntegrinsChapter 16: Intravital Imaging and Cell InvasionChapter 17: Using Xenopus Embryos to Investigate Integrin FunctionChapter 18: Methods to Study Lymphatic Vessel IntegrinsChapter 19: Analysis of Integrin Signaling in Genetically Engineered Mouse Models of Mammary Tumor ProgressionChapter 20: Design and Chemical Synthesis of Integrin Ligands
