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Immunity and Inflammation in Health and Disease: Emerging Roles of Nutraceuticals and Functional Foods in Immune Support provides a comprehensive description of the various pathways by which the vertebrate immune system works, the signals that trigger immune response and how fnew and novel nutraceuticals and functional foods, can be used to contain inflammation and also to boost immunity and immune health.
Inflammation is a tool to fight pathogens and the vertebrate immune system has a very complex network of cells to achieve this. However inflammation that goes awry is also the leding cause of several diseases ranging from cardiovascular diseases to diabetes. This book covers the entire gamut from the various cellular players in the inflammation-immune response to its ramifications in terms of protection against pathogens as well as in onset of metabolic, aging and auto-immune related diseases. Finally, the balancing role of dietary nutrients between host defence and immune support is also showcased. The first three scetions explain the various components of the immune system and their modes of activation. The fourth section deals with the ramifications of a robust and execessive inflammatory response. The fifth section is focused on the association between nutrition and immunity and how deficiencies in certain nutrients may affect immunocompetence. The sixth section chapters represent a vision of paradigm shifts within the field and discusses possible future directions.
This bool will be a valuable reference for researchers studying immune health either in academia, or in the nutraceutical or functional food industries. Product developers in nutraceutical, supplement, functional food, and health food companies will also appreciate the information presented here.
- Conceptualizes the key features in natural products which can boost immune function and immune health
- Explains the intricate mechanistic aspects and balance behind immune health
- Presents the pathophysiology of several diseases associated with immune system disruption
Language
Place of publication
Publishing group
Elsevier Science & Techn.
ISBN-13
978-0-12-805402-4 (9780128054024)
Schweitzer Classification
Section I: Innate and Adaptive Immune Systems: Components and Regulation1. Innate and Adaptive Immunity: Barriers and Receptor Based Recognition 2. Innate Immunity at Birth: Implications for Inflammation and Infection in Newborns3. Redox Signaling and Onset of the Inflammatory Cascade
Section II: Reactive Oxygen Species, Oxidative Stress and Immune Cell Activation4. Reactive Oxygen Species, Oxidative Damage and Cell Death5. Mitochondrial ROS and T Cell Activation6. Oxidants and Inflammation: Endothelial Targeting Of Antioxidants to Combat Disease7. Oxidative Signaling In Chronic Obstructive Airway Diseases
Section III: Inflammatory Systems: Mechanistic Pathways Of Stimulation and Suppression8. Immune Responses in the Upper Respiratory Tract in Health and Disease9. The Biological Role of NADPH Oxidases in Pulmonary Ischemia-Reperfusion Injury in Pulmonary Inflammation10. Receptor Blockade of CD26/DPP4 as a Therapeutic Strategy Against I/R Injury and Lymphocytic Inflammation And Its Clinical Implications11. DPPIV/CD26 as A Target in Anti-Inflammatory Therapy12. Redox Sensitive Transcription via Nrf2-Keap1 in Suppression of Inflammation
Section IV: Immunity and Inflammation: Common Threads Of Multifactorial Diseases13. Monogenic Defects of Toll-Loke receptor Signaling and Primary Immunodeficiency14. PPAthogen - and Microbial- Associated Molecular Patterns (PAMPs/MAMPs) in the Innate Immune Response in Crohn's Disease15. Inflammation and Calcification in the Vascular Tree; Insights into Atherosclerosis 16. From Inflammation to Cancer: Opportunites for Chemoprevention via Dietary Intervention 17. Inflammation in Bullous Pemphigoid, a Skin Auto-Immune Disease18. Inflammation in Systemic Immune Diseases: Role of TLR9 Signaling and the Resultant Oxidative Stress in Pathology of Lupus
Section V: Nutraceuticals in Boosting Immune Support and as Therapeutics for Inflammatory Diseases 19. Anti-inflammatory and Anti-microbial Properties of Achillea millefolium in Acne Treatment20. Lactobacillus Gasseri Potentiates Immune Response Against Influenza Virus Infection21. Micronutrients in Skin Immunity and Associated Diseases 22. Mycobiome and Gut Inflammation: Implications in Inflammatory Bowel Disease23. Flavonoids in Treating Psoriasis24. Probiotics and Anti-Inflammatory Processes in HIV Infected: From Benchside Research to Bedside25. Chronic Inflammation in Asthma: Anti-Malarial Drug Artesunate as a Therapeutic Agent 26. Nutrition as a Tool to Reverse Immunosenescence?
Section VI: New Perspectives and Future Directions27. Therapeutic Interventions to Block Oxidative Stress-Associated Pathologies28. Phytochemicals as Anti-Inflammatory Nutraceuticals and Phytophamaceuticals29. Fermented Milk in Protection Against Inflammatory Mechanisms In Obesity 30. Prebiotics and Probiotics in Altering Microbiota: Implications in Colorectal Cancer31. Naturopathy and Lifestyle Interventions in Boosting Immune Responses in HIV Positive Population32. Eating Habits and Fighting Disease: Nutraceuticals and Functional Foods at the Intersection of Immune Health and Inflammatory Responses