
Catecholamines: Bridging Basic Science with Clinical Medicine
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Content
- Front Cover
- Catecholamines: Bridging Basic Science with Clinical Medicine
- Copyright Page
- Contents
- Contributors
- Preface
- PART A: CATECHOLAMINE SYNTHESIS AND RELEASE
- Overview
- Section I: Regulation and Expression of Tyrosine Hydroxylase
- Chapter 1. The Effect of Phosphorylation at Ser-40 on the Structure and Thermal Stability of Tyrosine Hydroxylase
- Chapter 2. Factors Affecting Adrenal Medullary Catecholamine Biosynthesis and Release
- Chapter 3. Regulation of Tyrosine Hydroxylase by Neuropeptides
- Chapter 4. Regulation of Tyrosine Hydroxylase Gene Expression by Transsynaptic Mechanisms and Cell-Cell Contact
- Chapter 5. A New Regulatory Protein of Catecholamine Synthesizing- Enzyme Expression
- Chapter 6. Unique and Cell-Type-Specific Tyrosine Hydroxylase Gene Expression
- Chapter 7. Triple Colocalization of Tyrosine Hydroxylase, Calretinin, and Calbindin D-28k in the Periventricular-Hypophyseal Dopaminergic Neuronal System
- Chapter 8. Genetic Disorders Involving Recycling and Formation of Tetrahydrobiopterin
- Chapter 9. Genetic Basis of Dominant Dystonia
- Chapter 10. Mutations in the Tyrosine Hydroxylase Gene Cause Various Forms of L-Dopa-Responsive Dystonia
- Chapter 11. Catecholamine Biosynthetic Enzyme Expression in Neurological and Psychiatric Disorders
- Section II: Other Catecholamine-Synthesizing Enzymes
- Chapter 12. Multiple Pathways in Regulation of Dopamine ß-Hydroxylase
- Chapter 13. Examining Adrenergic Roles in Development, Physiology, and Behavior through Targeted Disruption of the Mouse Dopamine ß-Hydroxylase Gene
- Chapter 14. Genetic Diseases of Hypotension
- Chapter 15. Dopamine ß-Hydroxylase Deficiency Associated with Mutations in a Copper Transporter Gene
- Chapter 16. Glucocorticoid-Phenylethanolamine-N-methyltransferase Interactions in Humans
- Chapter 17. Determinants of Phenylethanolamine-N- methyltransferase Expression
- Chapter 18. Neural Control of Phenylethanolamine-N- methyltransferase via Cholinergic Activation of Egr- I
- Chapter 19. Synexin (Annexin VII) Hypothesis for Ca2+/GTP-Regulated Exocytosis
- Chapter 20. Monoamine Transmitter Release from Small Synaptic and Large Dense-Core Vesicles
- Chapter 21. Calcium Channels for Exocytosis in Chromaffin Cells
- Chapter 22. Characteristics of Transmitter Secretion from Individual Sympathetic Varicosities
- Chapter 23. Neurotransmitter Release at Individual Sympathetic Varicosities, Boutons
- Chapter 24. Appropriate Target Cells Are Required for Maturation of Neurotransmitter Release Function of Sympathetic Neurons in Culture
- Chapter 25. Effects of Neuropeptide Y at Sympathetic Neuroeffector Junctions
- Chapter 26. Strategies for Receptor Control of Neurotransmitter Release
- Chapter 27. Pattern of Adenosine Triphosphate and Norepinephrine Release and Clearance: Consequences for Neurotransmission
- Chapter 28. Corelease of Norepinephrine and Adenosine Triphosphate from Sympathetic Neurones
- Chapter 29. Neuropeptide Y: An Adrenergic Cotransmitter, Vasoconstrictor, and a Nerve-Derived Vascular Growth Factor
- Chapter 30. Neuropeptide Y: A Cardiac Sympathetic Cotransmitter?
- Chapter 31. Biochemistry of Somatodendritic Dopamine Release in Substantia Nigra: An in Vivo Comparison with Striatal Dopamine Release
- Chapter 32. The Use of Dual-Probe Microdialysis for the Study of Catecholamine Release in the Brain and Pineal Gland
- Chapter 33. Kinetics and Geometry of the Excitatory Dopaminergic Transmission in the Rat Striatum in Vivo
- Chapter 34. In Vivo and in Vitro Assessment of Dopamine Uptake and Release
- PART B: CATECHOLAMINE REUPTAKE AND STORAGE
- Overview
- Section I: The Plasma Membrane Transporters
- Chapter 1. Molecular Physiology and Regulation of Catecholamine Transporters
- Chapter 2. Localization of Dopamine Transporter Protein by Microscopic Histochemistry
- Chapter 3. Cellular and Subcellular Localization of the Dopamine Transporter in Rat Cortex
- Chapter 4. Cloned Catecholamine Transporters Expressed in Polarized Epithelial Cells: Sorting, Drug Sensitivity, and Ion-Coupling Stoichiometry
- Chapter 5. Inactivation of the Dopamine Transporter Reveals Essential Roles of Dopamine in the Control of Locomotion, Psychostimulant Response, and Pituitary Function
- Chapter 6. Role of Protein Kinase C and Second Messengers in Regulation of the Norepinephrine Transporter
- Chapter 7. Electrophysiological Analysis of Transporter Function
- Chapter 8. Voltammetric Approaches to Kinetics and Mechanism of the Norepinephrine Transporter
- Chapter 9. Voltage-Dependency of the Dopamine Transporter in Rat Brain
- Chapter 10. Modulation of Quantal Dopamine Release by Psychostimulants
- Chapter 11. Regulation of Dopamine Transporter mRNA Levels in the Central Nervous System
- Chapter 12. Structural Diversity in the Catecholamine Transporter Gene Family: Molecular Cloning and Characterization of an L-Epinephrine Transporter from Bullfrog Sympathetic Ganglia
- Chapter 13. Positron Emission Tomography Radiogands for Dopamine Transporters and Studies in Human and Nonhuman Primates
- Chapter 14. Single Photon Emission Computed Tomography Imaging of Dopaminergic Function: Presynaptic Transporter, Postsynaptic Receptor, and "Intrasynaptic" Transmitter
- Chapter 15. Dopamine Transporter Changes in Neuropsychiatric Disorders
- Section II: Vesicular Transporters and Catecholamine Storage
- Chapter 16. Molecular and Biochemical Studies of Rat Vesicular Monoamine Transporter
- Chapter 17. A Chimeric Vesicular Monoamine Transporter Dissociates Sensitivity t o Tetrabenazine and Unsubstituted Aromatic Amines
- Chapter 18. Ligand Recognition by the Vesicular Monoamine Transporters
- Chapter 19. Molecular Pharmacology of the Vesicular Monoamine Transporter
- Chapter 20. Ultrastructural Localization of the Vesicular Monoamine Transporter 2 in Mesolimbic and Nigrostriatal Dopaminergic Neurons
- Chapter 21. ICA 512, Receptor Tyrosine Phosphatase-Like Protein, is Concentrated in Neurosecretory Granule Membranes
- Chapter 22. Protein Targeting in Neurons and Endocrine Cells
- Chapter 23. The Vesicular Monoamine Transporter VMAT2 and Vesicular Acetylcholine Transporter VAChT Are Sorted to Separate Vesicle Populations in PC I 2 Cells
- Chapter 24. Recycling of Synaptic Vesicles
- Chapter 25. The Secretory Cocktail of Adrenergic Large Dense-Core Vesicles: The Functional Role of the Chromogranins
- Chapter 26. A Novel, Catecholamine Release-Inhibitory Peptide from Chromogranin A: Autocrine Control of Nicotinic Cholinergic-Stimulated Exocytosis
- Chapter 27. Transcription Regulation Coupled to Calcium and Protein Kinase Signaling Systems through TRE- and CRE-Like Sequences in Neuropeptide Genes
- Chapter 28. Imaging of Monoaminergic and Cholinergic Vesicular Transporters in the Brain
- PART C: CATECHOLAMINE METABOLISM: FROM MOLECULAR UNDERSTANDING TO CLINICAL DIAGNOSIS AND TREATMENT
- Overview
- Section I: Monoamine Oxidase
- Chapter 1. Monoamine Oxidase A and B: Structure, Function, and Behavior
- Chapter 2. Genetic Deficiencies of Monoamine Oxidase Isoenzymes: A Key to Understanding the Function of the Enzymes in Humans
- Chapter 3. Biological Markers, with Special Regard to Platelet Monoamine Oxidase (trbc-MAO), for Personality and Personality Disorders
- Chapter 4. Visualization of Monoamine Oxidase in Human Brain
- Chapter 5. Aliphatic N-Methylpropargylamines: Monoamine Oxidase-B Inhibitors and Antiapoptotic Drugs
- Chapter 6. Antiapoptotic Actions of Monoamine Oxidase B Inhibitors
- Chapter 7. Therapeutic Actions of L-Deprenyl in Dogs: A Model of Human Brain Aging
- Chapter 8. Apomorphine Is a Potent Radical Scavenger and Protects Cultured Pheochromocytoma Cells from 6-OHDA and H2O2-lnduced Cell Death
- Section II: O-Methylation and Conjugation
- Chapter 9. Catechol O-Methyltransferase: Characterization of the Protein, Its Gene, and the Preclinical Pharmacology of COMT Inhibitors
- Chapter 10. X-Ray Crystallography of Catechol O-Methyltransferase: Perspectives for Target-Based Drug Development
- Chapter 11. Catechol O-Methyltransferase Inhibition and the Treatment of Parkinson's Disease
- Chapter 12. The Structure and Function of the UDP- Glucuronosyltransferase Gene Family
- Chapter 13. Catecholamine Sulfation in Health and Disease
- Chapter 14. Metabolism of Endobiotics and Xenobiotics by UDP- Glucuronosyltransferase
- Section III: Catecholamine Metabolizing Systems
- Chapter 15. Molecular Structure of the Carrier Responsible for Hepatic Uptake of Catecholamines
- Chapter 16. Catecholamine Uptake and Metabolism in the Liver
- Chapter 17. Catecholamine Uptake and Metabolism in Rat Lungs
- Chapter 18. The Extraneuronal Monoamine Transporter Exists in Human Central Nervous System Glia
- Chapter 19. Removal of Circulating Catecholamines by Extraneuronal Amine Transport Systems
- Chapter 20. Catecholamine Metabolites in Internal Jugular Plasma: A Window into the Human Brain
- Chapter 21. Norepinephrine Metabolites in Plasma as Indicators of Pharmacological Inhibition of Monoamine Oxidase and Catechol O-Methyltransferase
- Chapter 22. The Adrenal Gland as a Source of Dihydroxyphenylalanine and Catecholamine Metabolites
- Chapter 23. Clues to the Diagnosis of Pheochromocytoma from the Differential Tissue Metabolism of Catecholamines
- PART D: CATECHOLAMINE RECEPTORS AND SIGNAL TRANSDUCTION
- Overview
- Section I: Structure, Classification, and Tissue Localization of Catecholamine Receptor Subtypes
- Chapter 1. Expression and Regulation of a1-Adrenergic Receptors in Human Tissues
- Chapter 2. a1-Adrenoceptor Subtypes in the Human Cardiovascular and Urogenital Systems
- Chapter 3. Molecular Mechanisms of Ligand Binding and Activation of a1-Adrenergic Receptors
- Chapter 4. Expansion of the Dopamine DI Receptor Gene Family: Defining Molecular, Pharmacological, and Functional Criteria for D I A, D I B, D I C, and D I D Receptors
- Chapter 5. DI/D3 Receptor Relationships in Brain: Coexpression, Coactivation, and Coregulation
- Chapter 6. Mapping the Binding-Site Crevice of the D2 Receptor
- Section II: lntracellular Mechanisms
- Chapter 7. Mechanisms of ß-Adrenergic Receptor Desensitization and Resensitization
- Chapter 8. Role of ß-Arrestins in the Intracellular Trafficking of G-Protein-Coupled Receptors
- Chapter 9. G-Protein-Linked Receptors as Substrates for Tyrosine Kinases: Cross-Talk in Signaling
- Chapter 10. Role of Arrestins in G-Protein-Coupled Receptor Endocytosis
- Chapter 11. Subtype-Specific Regulation of the ß-Adrenergic Receptors
- Chapter 12. Structural Determinants of a2-Adrenergic Receptor Regulation
- Chapter 13. Regulation of D2 and D3 Receptors in Transfected Cells by Agonists and Antagonists
- Chapter 14. Regulation of the D I Dopamine Receptor through CAMP- Mediated Pathways
- Chapter 15. Mechanisms for Activation of Multiple Effectors by a1- Adrenergic Receptors
- Chapter 16. Signal Transduction Pathways Modulated by D2-Like Dopamine Receptors
- Chapter 17. Guanosine Triphosphatase-Activating Proteins for Heterotrimetric G-Proteins
- Chapter 18. Regulation of the Stoichiometry of Protein Components of the Stimulatory Adenylyl Cyclase Cascade
- Chapter 19. Regulation of Mitogen-Activated Protein Kinase Pathways by Catecholamine Receptors
- Section III: Pharmacology
- Chapter 20. Examination of Ligand-Induced Conformational Changes in the ß2-Adrenergic Receptor by Fluorescence Spectroscopy
- Chapter 21. Relationship between a2-Adrenergic Receptors and Imidazoline/Guanidinium Receptive Sites
- Chapter 22. Dopamine D4 Receptors May Alleviate Antipsychotic- Induced Parkonsonism
- Chapter 23. Binding of Typical and Atypical Antipsychotic Drugs to Multiple Neurotransmitter Receptors
- Chapter 24. Structural and Functional Characteristics of the Dopamine D4 Receptor
- Chapter 25. NGD 94- I : A Specific Dopamine-4-Receptor Antagonist
- Section IV: Catecholamine Receptors in Physiology and Behavior
- Chapter 26. In Vivo Mutation of the a2A-Adrenergic Receptor by Homologous Recombination Reveals the Role of This Receptor Subtype in Multiple Physiological Processes
- Chapter 27. Regulation of Fat-Cell Function by a2-Adrenergic Receptors
- Chapter 28. The Developmental and Physiological Consequences of Disrupting Genes Encoding ß1 and ß2 Adrenoceptors
- Chapter 29. Myocardial Overexpression of Adrenergic Receptors and Receptor Kinases
- Chapter 30. Cardiac G-Protein Receptor Kinase Activity: Effect of a ß-Adrenergic Receptor Antagonist
- Chapter 31. Structure and Function of the ß3 Adrenoceptor
- Chapter 32. Behavioral Analysis of Multiple D I -Like Dopamine Receptor Subtypes: New Agents and Studies in Transgenic Mice with D I A Receptor Knockout
- Chapter 33. Antisense Knockdown of Brain Dopamine Receptors
- Chapter 34. The Physiological Role of Dopamine D2 Receptors
- Section V: Pathophysiological States
- Chapter 35. Regulation of D I Receptor Function in Spontaneous Hypertension
- PART E: CATECHOLAMINES IN THE PERIPHERY
- Overview
- Section I: Assessment of Peripheral Catecholaminergic Function
- Chapter 1. *Peripheral Catecholaminergic Function Evaluated by Norepinephrine Measurements in Plasma, Extracellular Fluid, and Lymphocytes, from Nerve Recordings and Cellular Responses
- Chapter 2. Cardiac Microdialysis
- Chapter 3. Sympathetic Microneurography and Neurocirculatory Function: Studies of Ventricular Arrhythmias in Humans
- Section II: Catecholamines and Stress
- Chapter 4. Stress as a Medical and Scientific Idea and Its Implications
- Chapter 5. Stressor Specificity of Peripheral Catecholaminergic Activation
- Chapter 6. Stressor-Specific Activation of Catecholaminergic Systems: Implications for Stress-Related Hypothalamic- Pituitary-Adrenocortical Responses
- Chapter 7. Regulation of Gene Expression of Catecholamine Biosynthetic Enzymes by Stress
- Section III: Catecholamines and Pain
- Chapter 8. Peripheral Modulatory Effects of Catecholamines in Inflammatory and Neuropathic Pain
- Chapter 9. Brain Catecholamine Systems in Stress
- Chapter 10. a2-Adrenergic Mechanisms of Analgesia: Strategies for Improving Their Therapeutic Window and Identification of the Novel, Potent a2A-Adrenergic Receptor Agonist, S 18616
- Chapter 11. Cellular Transplantation for Intractable Pain
- Section IV: Catecholamines and Neuroimmunology
- Chapter 12. The Role of the Sympathetic Nervous System in the Modulation of Immune Responses
- Chapter 13. Catecholamines, Catecholamine Receptors, Cell Adhesion Molecules, and Acute Stressor-Related Changes in Cellular Immunity
- Chapter 14. Nerve Growth Factor and Autoimmune Disease: Role of Tumor Necrosis Factor- a?
- Section V: Adrenomedullary Secretion and Co-Secretion
- Chapter 15. Multiple Transmitter Control of Catecholamine Secretion in Rat Adrenal Medulla
- Chapter 16. Adrenomedullin in Cardiovascular Disease
- Chapter 17. Strychnine, Glycine, and Adrenomedullary Secretion
- Section VI: Neurocardiology
- Chapter 18. Catecholamines and Neurocardiogenic Syncope
- Chapter 19. ß-Blockers in Congestive Heart Failure: The Pharmacology of Carvedilol, a Vasodilating ß-Blocker and Antioxidant, and Its Therapeutic Utility in Congestive Heart Failure
- Chapter 20. Sympathetic Cardioneurotherapy in Dysautonomias
- Section VII: Catecholamines and Metabolism
- Chapter 21. Hypoglycemia-Associated Autonomic Failure in Insulin- Dependent Diabetes Mellitus
- Chapter 22. Mechanisms of the Sympathoadrenal Response to Hypoglycemia
- Chapter 23. Importance of Catecholamines in Defense against Insulin Hypoglycemia in Humans
- Chapter 24. Sympathetic Nervous Activity and the Thermic Effect of Food in Humans
- Chapter 25. Microdialysis for the Assessment of Catecholamine-Induced Lipolysis in Human Adipose and Skeletal Muscle Tissue
- Section VIII: Catecholamines in the Bruin and Regulation of the Cardiovascular System
- Chapter 26. Bulbospinal Cl -Adrenergic Neurons: Electrophysiological Properties in the Neonate Rat
- Chapter 27. Catecholamines, Opioids, and Vagal Afferents in the Nucleus of the Solitary Tract
- Chapter 28. Agmatine: A Novel Neurotransmitter?
- Chapter 29. Central and Peripheral Norepinephrine Kinetics in Heart Failure, Coronary Artery Disease, and Hypertension
- PART F: CATECHOLAMINES IN THE CENTRAL NERVOUS SYSTEM
- Overview
- Chapter 1. Dopamine-Mediated Gene Regulation in the Striatum
- Chapter 2. Dopamine Control of Gene Expression in Basal Ganglia Nuclei: Striatal and Nonstriatal Mechanisms
- Chapter 3. Dopaminergic Regulation of Immediate Early Gene Expression in the Basal Ganglia
- Chapter 4. Dopamine and Calcium Signal Interactions in the Developing Striatum: Control by Kinetics of CREB Phosphorylation
- Chapter 5. The Phasic Reward Signal of Primate Dopamine Neurons
- Chapter 6. Afferent Control of Midbrain Dopamine Neurons: An lntracellular Perspective
- Chapter 7. GABAergic Control of the Firing Pattern of Substantia Nigra Dopaminergic Neurons
- Chapter 8. Afferent Control of Substantia Nigra Compacta Dopamine Neurons: Anatomical Perspective and Role of Glutamatergic and Cholinergic Inputs
- Chapter 9. Dopamine Axons in Primate Prefrontal Cortex: Specificity of Distribution, Synaptic Targets, and Development
- Chapter 10. The Cortical Dopamine System: Role in Memory and Cognition
- Chapter 11. Norepinephrine-Dopamine Interactions in the Prefrontal Cortex and the Ventral Tegmental Area: Relevance to Mental Diseases
- Chapter 12. Dopamine Function in the Prefrontal Cortex
- Chapter 13. The Modulation of Corticoaccumbens Transmission by Limbic Afferents and Dopamine: A Model for the Pathophysiology of Schizophrenia
- Chapter 14. Dopamine Modulation of Responses Mediated by Excitatory Amino Acids in the Neostriatum
- Chapter 15. The Molecular Basis of Dopamine and Glutamate Interactions in the Striatum
- Chapter 16. Modulation by Dopamine of Rat Corticostriatal Input
- Chapter 17. Dopamine, Glutamate, and Behavioral Correlates of Striatal Neuronal Activity
- Chapter 18. State-Related Activity, Reactivity of Locus Ceruleus Neurons in Behaving Monkeys
- Chapter 19. Modulation of Forebrain Electroencephalographic Activity and Behavioral State by the Locus Ceruleus-Noradrenergic System: Involvement of the Medial Septa1 Area
- Chapter 20. New Perspectives on the Functional Organization and Postsynaptic Influences of the Locus Ceruleus Efferent Projection System
- Chapter 21. Neuromodulation and Cognitive Performance: Recent Studies of Noradrenergic Locus Ceruleus in Behaving Monkeys
- Chapter 22. Noradrenergic Effects on Activity of Prefrontal Cortical Neurons in Behaving Monkeys
- Chapter 23. Noradrenergic Influences on Prefrontal Cortical Cognitive Function: Opposing Actions at Postjunctional a1- Versus a2-Adrenergic Receptors
- Chapter 24. Afferent Control of Nucleus Locus Ceruleus: Differential Regulation by "Shell" and "Core" Inputs
- Chapter 25. Sensory Response of the Locus Ceruleus: Neonatal and Adult Studies
- Chapter 26. Noradrenergic Modulation of the Prefrontal Cortex as Revealed by Electron Microscopic Immunocytochemistry
- Chapter 27. Activation of the Locus Ceruleus Brain Noradrenergic System during Stress: Circuitry, Consequences, and Regulation
- Chapter 28. Norepinephrine and Schizophrenia: A New Hypothesis for Antipsychotic Drug Action
- Chapter 29. Neurochemical Responses to Lesions of Dopaminergic Neurons: Implications for Compensation and Neuropathology
- Chapter 30. Dopamine Receptor Subtypes as Targets for the Pharmacotherapy of Parkinson's Disease
- Chapter 31. Free Radicals and MPTP-Induced Selective Destruction of Substantia Nigra Compacta Neurons
- Chapter 32. Application of Gene Therapy for Parkinson's Disease: Nonhuman Primate Experience
- Chapter 33. Prefrontal Cortical and Hippocampal Modulation of Dopamine-Mediated Effects
- Chapter 34. Dysregulation of Mesoprefrontal Dopamine Neurons Induced by Acute and Repeated Phencyclidine Administration in the Nonhuman Primate: Implications for Schizophrenia
- Chapter 35. Interactions between Catecholamines and Serotonin: Relevance to the Pharmacology of Schizophrenia
- PART G: NOVEL CATECHOLAMINERGIC SYSTEMS
- Overview
- Section I: Catecholestrogens
- Chapter 1. Catecholestrogens in the Induction of Tumors in the Kidney of the Syrian Hamster
- Chapter 2. Biosynthesis and Inactivation of Catecholestrogens
- Chapter 3. Catecholestrogens as Procarcinogens: Depurinating Adducts and Tumor Initiation
- Chapter 4. Role of Aromatic Hydrocarbons in Disclosing How Catecholestrogens Initiate Cancer
- Chapter 5. Embryo Implantation Requires Estrogen-Directed Uterine Preparation and Catecholestrogen-Mediated Embryonic Activation
- Section II: Nonneuronal Biosynthesis of Catecholamines
- Chapter 6. Extra-Adrenal Nonneuronal Epinephrine and P henylethanolamine-N-methyltransferase
- Chapter 7. Dopamine and the Brain-Gut Axis
- Chapter 8. Origin and Significance of Plasma Dihydroxyphenylalanine
- Section III: Is L-Dopa Neurotransmitter?
- Chapter 9. Is L-Dopa a Neurotransmitter of the Primary Baroreceptor Afferents Terminating in the Nucleus Tractus Solitarri of Rats?
- Chapter 10. lmmunocytochemical Evidence of Novel Catecholamine- or Biopterin-Related Neurons of Mammalian Brain
- Chapter 11. Fluorinated Dihydroxyphenylserines as Potential Biological Precursors of Fluorinated Norepinephrines
- Section IV: Dopamine as a Renal Autocrine-Paracrine Substance
- Chapter 12. Nonneuronal Dopamine
- Chapter 13. The Renal Dopamine System
- Chapter 14. Renal Dopamine Production and Release in the Rat: A Microdialysis Study
- PART H: DEVELOPMENT AND PLASTICITY
- Overview
- Chapter 1. Inductive Interactions Underlie Neural Crest Formation
- Chapter 2. Lineage Commitment and Fate of Neural Crest-Derived Neurogenic Cells
- Chapter 3. The Differentiation of the Neurotransmitter Phenotypes in Chick Sympathetic Neurons
- Chapter 4. Developmental Regulation of Neurotransmitters in Sympathetic Neurons
- Chapter 5. Changes in Gene Expression in Adult Sympathetic Neurons after Axonal Injury
- Chapter 6. Ontogeny of Vesicular Amine Transporter Expression in the Rat: New Perspectives on Aminergic Neuronal and Neuroendocrine Differentiation
- Chapter 7. Specification and Survival of Dopaminergic Neurons in the Mammalian Midbrain
- Chapter 8. Effects of Glial Cell Line-Derived Neurotrophic Factor on the Nigrostriatal Dopamine System in Rodents and Nonhuman Primates
- Chapter 9. Cell Body Functions of Brain-Derived Neurotrophic Factor Increase Forebrain Dopamine Release and Serotonin Metabolism Determined with in Vivo Microdialysis
- Chapter 10. Neurotrophin Modulation of Hippocampal Synaptic Transmission
- Chapter 11. Genotype and Phenotype in Familial Dysautonomia
- Chapter 12. A Gene Therapy Approach for the Treatment of Amyotrophic Lateral Sclerosis and Parkinson's Disease
- Chapter 13. Characterization of Adrenal Chromafin Progenitor Cells in Mice
- Chapter 14. Evolution and Origin of the Diversity of Dopamine Receptors in Vertebrates
- Chapter 15. Neurogenetics of Synaptic Transmission in Caenorhabditis elegans
- Chapter 16. Decapitated Drosophila: A Novel System for the Study of Biogenic Amines
- Chapter 17. Dopaminergic Control of Serotonergic Neuron Development in the Grasshopper Central Nervous System
- Chapter 18. Noradrenergic Long-Term Potentiation in the Dentate Gyrus
- Chapter 19. Rapid Acquisition of Discriminative Responding in Monkey Locus Coeruleus Neurons
- Chapter 20. Catecholaminergic Contributions to Early Learning
- Chapter 21. Interactions between Catecholamines and the Amygdala in Emotional Memory: Subclinical and Clinical Evidence
- PART I: DRUG ABUSE AND ALCOHOLISM
- Overview
- Chapter 1. Circuits, Drugs, and Drug Addiction
- Chapter 2. Homologies and Differences in the Actions of Drugs of Abuse and a Conventional Reinforcer (Food) on Dopamine Transmission: An Interpretative Framework of the Mechanism of Drug Dependence
- Chapter 3. Drug-Induced Adaptations in Catecholamine Systems: On the Inevitability of Sensitization
- Chapter 4. Neurobiological Substrates Underlying Conditioned Effects of Cocaine
- Chapter 5. The Rate Hypothesis and Agonist Substitution Approaches to Cocaine Abuse Treatment
- Chapter 6. Drugs of Abuse and Dopamine Cell Activity
- Chapter 7. DI -Receptor Regulation of Synaptic Potentials in the Ventral Tegmental Area after Chronic Drug Abuse
- Chapter 8. Neuroadaptations in Nucleus Accumbens Neurons Resulting from Repeated Cocaine Administration
- Chapter 9. Dopamine Efflux Studies into the in Vivo Actions of Psychostimulant Drugs
- Chapter 10. Psychostimulants and Neuropeptide Response
- Chapter 11. Drugs of Abuse and Striatal Gene Expression
- Chapter 12. Coordinated Expression of Dopamine Receptors in Neostriatal Medium Spiny Neurons
- Chapter 13. Dopaminergic Genes and Substance Abuse
- Chapter 14. Quantitative Trait Loci: Mapping Drug and Alcohol- Related Genes
- Chapter 15. Nuclear Memory: Gene Transcription and Behavior
- Chapter 16. Phosphorylation of Dopamine Transporters and Rapid Adaptation to Cocaine
- Index
- Contents of Previous Volumes
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