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Developmental Aspects of the Cell Cycle discusses the molecular, organelle, cellular, and organismal levels of cell cycle, cell proliferation, and cell differentiation. It addresses the possible antagonism between the ability of cells to proliferate and to differentiate. After brief historical, theoretical, and methodological background information for each cell system, this book concentrates on the mechanisms involved in the regulation of cell proliferation and differentiation. The book presents systems in which mass cultures of cells can be induced to undergo a synchronous transition from one cell state to another, enabling the amplification of cellular and biochemical events to be analyzed with the available morphological and biochemical techniques. Some chapters explain the possibility of cell state production by a microenvironment that occurs at the organismal level, in which a series of mitotic and growth steps causes cells proliferation. The concluding chapters discuss cell proliferation and differentiation in specific cell system, such as embryonic chick and male germ cell. This book will appeal to investigators in many disciplines, teachers, and life sciences students, particularly, to molecular, cellular, and developmental biologists.
Language
Place of publication
Publishing group
Elsevier Science & Techn.
ISBN-13
978-0-323-15209-9 (9780323152099)
Schweitzer Classification
List of ContributorsPreface1. The Cell Cycle and Cell Differentiation in Trypanosomatids I. Introduction II. Life Cycles and Cell Differentiation III. Cell Cycles and Differentiation References2. Characteristics of Macronuclear RNA in the Cell Cycle of Synchronized Tetrahymena I. Introduction II. Nucleocytoplasmic Interactions III. Stomatogenesis and Polyribosomal Assembly IV. Nucleic Acid Synthesis V. Summary and Concluding Remarks References 3. Cell Transformation Studies on the Amoeba-Flagellate, Naegleria gruberi I. Introduction II. Historical Aspects III. Modern Studies IV. Concluding Remarks References 4. Temporal Patterns in the Ciliated Protozoa I. The Nature of Temporal Events II. Maturity Patterns in Tetrahymena III. Mechanisms of Temporal Control IV. Concluding Remarks References 5. Mitosis and Differentiation in Hydra Morphogenesis I. Introduction II. Structural Aspects III. Selection of Experimental Hydra IV. Techniques for Analyzing Mitosis in Hydra V. Effects of Mitotic Inhibitors on Regeneration and Morphogenesis VI. Concluding Remarks References 6. Radiation Responses during the Mitotic Cycle of the Sea Urchin Egg I. Introduction II. General Effects of Irradiating Gametes or Zygotes III. Effects on Sperm IV. Effects on Unfertilized Eggs V. Cyclical Changes VI. Questions Concerning Targets VII. General Conclusions and Considerations for the Future References7. Cell Division and Transcription in Developing Frog Embryos I. Relation of Cell Division to Differentiation II. RNA Synthesis in Developing Frog Embryos III. Relation of Transcription to Time of DNA Replication IV. Effect of Rate and Number of Divisions on Transcription V. Summary References 8. Relationship between Cell Proliferation and Cytodifferentiation in Embryonic Chick Tissues I. Introduction II. Review of Individual Developing Systems III. Discussions and Conclusions References 9. Studies on Cellular Proliferation and Chondrogenesis I. Introduction II. Cell Cycle and Chondrogenesis III. Discussion IV. Summary References 10. Differentiation of the Male Germ Cell I. Introduction II. The Cycle of the Seminiferous Epithelium III. Gametogenesis IV. Final Stages of Spermatozoan Differentiation-The Female Reproductive Tract References11. Immunoglobulin Production in Proliferating Lymphoid Cells I. Introduction II. Immunoglobulin Synthesis in Relation to Culture Dynamics III. Immunoglobulin Gene Expression during the Cell Cycle IV. Discussion V. Summary References 12. Initial Stages of Cellular Differentiation in the Blood-Forming System of the Mouse I. Introduction II. Cellular Organization in the Hemopoietic System III. Regulation of Stem Cell Functions IV. Summary References 13. Hormonal Regulation of Cell Proliferation and Differentiation I. Introduction II. Hormonal Regulation of Cell Proliferation III. Hormone-Dependent Cell Differentiation IV. Relationship of Proliferation to Differentiation V. Some Possible Mechanisms in Hormonal Regulation of Gene Expression VI. Summary ReferencesAuthor IndexSubject Index