Neural Models of Plasticity

ContributorsPreface1 Associative Learning, Memory, and Neuromodulation in Hermissenda Introduction Organization of the Central Nervous System Conditioning Procedure Associative and Nonassociative Contributions to Phototactic Suppression Neuromodulation: Possible Contribution to Conditioning Short- and Long-Term Plasticity Discussion and Conclusions References2 Developmental Assembly of Multiple Components of Learning and Memory in Aplysia Introduction Different Forms of Learning in Aplysia Emerge According to Different Developmental Timetables Cellular Analogs of Learning Have the Same Developmental Timetables as Their Respective Behavioral Forms of Learning Analysis of Nondecremented Responses Prior to the Emergence of Sensitization Reveals a Novel Inhibitory Process Sensitization Emerges Simultaneously in Different ResponseSystems in Aplysia Widespread Proliferation of Central Neurons Occurs in the Same Developmental Stage as the Emergence of Sensitization Concluding Remarks References3 Turtles All the Way Down: Some Molecular Mechanisms Underlying Long-Term Sensitization in Aplysia Molecular Components Underlying Sensitization Long-Term Sensitization Is Accompanied by a Decrease in Regulatory Subunits A Molecular Mechanism for Enhanced Protein Phosphorylation The Mechanism by Which R Subunits Are Diminished Role of Synthesizing New Proteins for Long-Term Memory: The Mechanism behind the Other Mechanisms? Turtles All the Way Down: An Indian Story References4 Mathematical Model of Cellular and Molecular Processes Contributing to Associative and Nonassociative Learning in Aplysia Introduction Subcellular Model for Associative and Nonassociative Learning Simulation and Predictions of the Model Discussion References5 A Simple Circuit Model for Higher-Order Features of Classical Conditioning Behavioral and Cellular Studies of Learning in Aplysia A Quantitative Model for Conditioning Simulations of Basic Features of Conditioning Simulations of Higher-Order Features of Conditioning Discussion References6 The Hebb Rule for Synaptic Plasticity: Algorithms and Implementations Introduction Levels of Analysis Implementations of the Hebb Rule Conditioning Conclusions References7 Classical Conditioning Phenomena Predicted by a Drive-Reinforcement Model of Neuronal Function Introduction The Neuronal Model Predictions of the Model Experimental Tests Summary References Appendix: Parameter Specifications for the Computer Simulations of the Neuronal Models8 Olfactory Processing and Associative Memory: Cellular and Modeling Studies Introduction Feeding Command Neurons The LIMAX Model Behavioral Aspects of the LIMAX Model Challenges to Umax from LIMAX Challenges to LIMAX from Umax Future Directions References9 Neural Circuit for Classical Conditioning of the Eyelid Closure Response Introduction The Dorsal Accessory Olive-Climbing Fiber System-The Essential US Reinforcing (Teaching) Pathway? The Nature of Reinforcement in Classical Conditioning and the Role of Climbing Fibers References10 Long-Term Depression: Possible Cellular Mechanism for Learning Mediated by the Cerebellum Introduction Specification of LTD Involvement of Glutamate Receptors in LTD Involvement of Ca2+ Inflow in LTD Role of LTD in the Vestibulo-Ocular Reflex Discussion References11 Simulation of a Classically Conditioned Response: A Cerebellar Neural Network Implementation of the Sutton-Barto-Desmond Model Introduction The Model Neural Implementation in Cerebellum References12 Memory and the Hippocampus Introduction Human Amnesia Amnesia Can Result from Hippocampal Damage The Neuropsychological Data The Neurophysiological Data The Neuroanatomical Data: Topography of Sensory Inp