The Cell Nucleus V3

List of Contributors Preface Contents of Other Volumes IntroductionPart I Nucleic Acids Chapter 1 Nuclear DNA I. The Organization of Bacterial and Viral DNA II. The Nuclear DNA of Eukaryotic Organisms III. Genetic Organization of Eukaryotic DNA IV. Replication of Eukaryotic DNA V. Conclusions and Summary References Chapter 2 Nuclear DNA Polymerases I. Introduction II. DNA Polymerases of Escherichia colt III. DNA Polymerases from Nuclei IV. Evidence for the Involvement of the 6-8 DNA Polymerase Activity in Nuclear Events V. A Comparison of the Properties of the 3.3 S and 6-8 S DNA Polymerases VI. Primer Requirements and Template Specificity VII. Interrelation between 3.3 S and 6-8 S DNA Polymerase Activities References Chapter 3 Precursor of mRNA (Pre-mRNA) and Ribonucleoprotein Particles Containing Pre-mRNA I. Precursor of Messenger RNA II. Ribonucleoprotein Particles Containing Pre-mRNA References Chapter 4 Nuclear High-Molecular-Weight RNA I. Introduction II. Fractionation of Nuclear Substructures and Their Associated High-Molecular-Weight RNA III. Heterogeneous Nucleoplasmic High-Molecular-Weight RNA (HnRNA) IV. Nucleolar High-Molecular-Weight RNA References Chapter 5 Low-Molecular-Weight Nuclear RNAs I. Introduction II. Classification and Number of Low-Molecular-Weight RNAs III. Localization of Low-Molecular-Weight RNA in the Cell IV. Low-Molecular-Weight RNA in Various Tissues V. General Procedure for the Purification of Low-Molecular-Weight RNA VI. Sequence Analysis of Low-Molecular-Weight RNA VII. Structure and Function of Low-Molecular-Weight RNA VIII. Conclusion ReferencesPart II Nuclear Proteins Chapter 6 Nuclear Proteins I. Introduction II. General Characteristics of Histones III. The Structures of Histones IV. Histones and Chromatin Structure V. Modified Amino Acids in Histones VI. Histone Synthesis and Metabolism VII. Functions of Histones VIII. Nonhistone Nuclear Proteins IX. The Nuclear Enzymes References Chapter 7 Animal Nuclear DNA-Dependent RNA Polymerases I. Introduction II. Purification of Mammalian Nuclear RNA Polymerases III. Intracellular Localization and Relative Concentrations IV. Structure of the Multiple RNA Polymerases V. General Properties of Animal RNA Polymerases VI. Template Specificity of Animal RNA Polymerases VII. Inhibitors of Animal RNA Polymerases VIII. Physiological Role of the Various Animal Nuclear RNA Polymerases IX. In Vivo Regulation of Animal RNA Polymerase Activities X. Conclusion and Prospects References Chapter 8 Cytochemistry of Nuclear Enzymes I. Introduction II. Technical Problems III. Cytochemically Detected Enzymes in the Cell Nucleus IV. Cytochemically Demonstrable Enzymes in the Nuclear Envelope V. Concluding Remarks References Chapter 9 Nuclear Protein Synthesis I. Introduction II. Extranuclear Synthesis of Nuclear Proteins III. Intranuclear Protein Synthesis IV. Summary and Conclusions Note Added in Proof References Part III Special Aspects of Nuclear Function Chapter 10 Effects of Female Steroid Hormones on Target Cell Nuclei I. Introduction II. Steroid Hormone Receptors III. Transfer of the Hormone-Receptor Complex to the Nucleus IV. Hormone-Receptor Binding to DNA V. Hormone-Receptor Interaction with Chromatin Nonhistone Proteins VI.