Fundamentals and Applications of Immunoadsorption
2nd Edition
Published on 18. December 2013
103 pages
978-3-8374-5432-1 (ISBN)
Description
This textbook provides a comprehensive summary of current adsorption techniques applicable in humans. Immunoadsorption may be considered for a variety of indications, including rare nephrological conditions, dilated cardiomyopathy, autoimmune bullous diseases and autoimmune encephalitis. The main focus, however, has been laid on transplantation. The reader will find protocols for ABO-incompatible transplantation as well as for antibody-mediated rejection in heart, lung and kidney transplantation.
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Content
- Intro
- Authors
- Contents
- 1. Immunoadsorption Devices and Technique
- 2. Rationale for Immunoadsorption in Autoimmune Encephalitis
- 2.1. Paraneoplastic autoimmune encephalitis
- 2.2. Paraneoplastic and nonparaneoplastic autoimmune encephalitis probably mediated by antibodies to neuronal surface membrane a
- 2.3. Effects of therapeutic apheresis in autoimmune encephalitis
- 3. Immunoadsorption for Neurological Diseases
- 3.1. Immunological basis and rationale for immunoadsorption
- 3.2. Clinical applications
- 3.2.1. Autoimmune ion channel disorders
- 3.2.2. Disorders of peripheral nerves
- 3.2.3. Disorders of the central nervous system
- 3.2.3.1. Inflammatory CNS disorders
- 3.2.3.2. Immunotherapy-responsive, antibody-associated encephalitis
- 3.3. Future research
- 4. Rationale of Immunoadsorption in Cardiomyopathy
- 5. Immunoadsorption for Dilated Cardiomyopathy - Clinical Results
- 5.1. Disturbances of the immune system in patients with dilated cardiomyopathy
- 5.2. Clinical studies for immunoadsorption in dilated cardiomyopathy
- 5.3. Mechanisms of immunoadsorption in dilated cardiomyopathy
- 5.4. Summary
- 6. Immunoadsorption Treatment for Autoimmune Bullous Diseases
- 6.1. Immunoadsorption in pemphigus
- 6.1.1. Prospective controlled multicenter study
- 6.2. Immunoadsorption in pemphigoid diseases
- 6.2.1. Adverse events
- 6.3. Recommendations
- 6.3.1. (Contra-) indications
- 6.3.2. Treatment protocol
- 6.4. Conclusions
- 7. Immunoadsorption Rescue Therapy in Nephrology
- 7.1. Thrombotic thrombocytopenic purpura and hemolytic uremic syndrome
- 7.2. Systemic lupus erythematosus
- 7.3. ANCA-associated small vessel vasculitides
- 7.4. Anti-glomerular basement membrane antibody disease (Goodpasture's disease)
- 7.5. Focal segmental glomerulosclerosis
- 7.6. Paraproteinemia
- 8. Antibody Detection in Eluates from Transplant Patients Treated with Immunoadsorption (IA)
- 8.1. Antibody detection
- 9. ABO-Incompatible Organ Transplantation
- 9.1. ABO-incompatible kidney transplantation
- 9.1.1. ABO expression in the kidney
- 9.1.2. Technique to determine ABOincompatible titer
- 9.1.3. Techniques and protocol for ABO-incompatible kidney transplantation
- 9.1.4. Transfusion after ABO-incompatible kidney transplantation
- 9.1.5. Kidney biopsy after ABOincompatible transplantation
- 9.1.6. Outcome after ABO-incompatible kidney transplantation
- 9.2. ABO-incompatible liver transplantation
- 9.3. ABO-incompatible heart transplantation
- 9.4. Outlook
- 10. Antibody-Mediated Rejection in Kidney Transplantation
- 10.1. The concept of alloantibody mediated rejection
- 10.1.1. AMR types
- 10.1.2. C4d and the role of complement
- 10.2. Diagnosis of antibodymediated rejection (AMR)
- 10.2.1. The diagnostic value of renal allograft biopsy
- 10.2.2. Diagnostic criteria for acute AMR
- 10.2.3. Diagnostic criteria for chronic AMR
- 10.3. Frequency and natural course of acute AMR
- 10.4. Treatment of acute AMR - general remarks
- 10.5. Immunoadsorption in the treatment of acute AMR
- 10.5.1. Uncontrolled series
- 10.5.2. Results of a randomized controlled trial
- 10.6. Plasmapheresis-based protocols
- 10.7. Treatment of acute AMR - Level of evidence?
- 10.8. Treatment of chronic AMR
- 11. Antibody-MediatedRejectioninHeartandLung Transplantation-ExperienceswithImmunoadsorption
- 11.1. Cardiac dysfunction after HTX mediated by antibodies
- 11.2. Pulmonary dysfunction after LuTX mediated by antibodies
- 11.3. Stages of humoral response to an organ graft
- 11.4. HLA-ab and non-HLA-ab detection
- 11.5. Desensitization protocols
- 11.6. Experiences with Immunoadsorption
- 11.7. Summary
- Index
