Control of Animal Cell Proliferation

ContributorsPrefaceContents of Volume 1I. Trends and Issues 1 Membrane Structure and Function I. Introduction II. Membrane Organization III. Membrane Dynamics IV. Diffusion-Coupled Reactions and Membrane Function V. Some Current Problems in Membrane Structure VI. Concluding Comment References 2 Trends in Teratocarcinoma Research I. Introduction II. Embryo-Derived Stem Cells III. Growth Factors and Oncogenes IV. Conclusions and Prospects ReferencesII. Growth Factors 3 Transforming Growth Factors I. Introduction II. Transforming Growth Factor Type a III. Transforming Growth Factor Type ß IV. Other Transforming Growth Factors V. Summary and Conclusions References 4 Commitment in Blood Cell Differentiation: Erythropoietin as an Instructive Signal I. Introduction II. Biologically Active Factors III. Precursor Cells IV. Models of Blood Cell Differentiation References 5 Granulocyte-Macrophage Colony-Stimulating Factors I. Introduction II. Murine Granulocyte-Macrophage Colony-Stimulating Factors III. CSFs and Oncogenes IV. Actions of the CSFs V. In Vivo Significance of the CSFs VI. Summary References 6 Structural Regions and Bioregulatory Functions of Thrombin I. Introduction II. Prothrombin Structure III. Thrombin Structure IV. Active-Site Regions V. Specificity and Bioregulatory Functions References 7 Transferrin I. Introduction II. Isolation and Purification of Transferrin III. Physical Properties of Transferrin IV. Ligands of the Metal and Anion Binding Sites V. The Synergistic Anion Binding Site VI. Iron Exchange by Transferrin References 8 Glucocorticoid Enhancement of Cellular Proliferation In Vitro I. Introduction II. Effects of Glucocorticoids on Cellular Proliferation III. Additional Effects of Glucocorticoids In Vitro IV. Enhanced Proliferation of Human Fetal Lung Fibroblasts in the Presence of Glucocorticoid-Conditoned Medium V. Summary References 9 B Cell and T Cell Growth Factors I. Overview II. Consensus Model of the T Cell Response III. Consensus Model of the B Cell Response IV. History V. T Cell Growth Factors VI. B Cell Growth Factors VII. Summary and Conclusions ReferencesIII. Receptors 10 Characterization of the Thrombin Receptor and Its Involvement in Initiation of Cell Proliferation I. Introduction II. Demonstration of High-Affinity Thrombin Receptors III. Visualization of Thrombin Binding Sites IV. Internalization and Degradation of Thrombin: Thrombin Receptors vs. Protease-Nexin V. Receptor-Cytoskeletal Interactions VI. Characterization of Thrombin Receptors on Fibroblasts VII. Role of Thrombin Receptors in Initiation of Cell Proliferation VIII. Characterization of Thrombin Mitogenic Signals IX. Two-Signal Model for Thrombin Mitogenesis X. Effect of Transformation on Thrombin Binding and Effect of Thrombin on Transformation References 11 The Transferrin Receptor I. Introduction II. Transferrin Receptor Expression and Cell Proliferation III. Evidence for Possible Roles for Transferrin Receptor Other Than Cellular Iron Uptake IV. Conclusions References 12 Glucocorticoid Hormone Receptors I. Introduction II. Receptor Assays III. Purification of Glucocorticoid Receptors IV. Structure of the Glucocorticoid Receptor V.