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The Biochemistry and Physiology of Bone, Second Edition: Volume I: Structure focuses on the nature and behavior of bone cells, the structure of the organic matrix of bone, mineral organization, and bone strength. It explores the histology of bone, the pathological calcification and radiation effects on bone, particularly, the morphology and cytochemistry as well as the functional significance of osteoblasts, the mode of action of the osteoclast, the ultrastructure of bone, and the mechanical engineering problems presented by bone. Organized into nine chapters, this edition begins with an overview of the general histology of bone, including tissues related to bone and its elementary constituents. It then discusses the origin of osteoblasts, the role of the osteoclast in the mechanism whereby calcium is unlocked from the skeleton under the influence of the parathyroid hormone, and the physiological and pathological effects of vitamins and hormones on skeletal tissue in vitro. It also explains the chemical composition of bone and the chemistry of bone collagen, the relationship between bone mineral and the organic matrix, the macromolecular organization of apatite and collagen, and the examinations of bone by scanning electron microscopy. The book concludes with a chapter on the shape, strength, and elasticity of bone. This book is a valuable source of information for anatomists, orthopedists, biochemists, cell biologists, physiologists, biomedical engineers, pathologists, clinicians, graduate students, professors, and others interested in the biochemical and physiological aspects of bone.
Edition
Language
Place of publication
Publishing group
Elsevier Science & Techn.
ISBN-13
978-0-323-16180-0 (9780323161800)
Schweitzer Classification
List of ContributorsPreface to Second EditionPreface to First EditionContents of Other VolumesChapter 1. General Histology of Bone I. Introduction II. Tissues Related to Bone III. Elementary Constituents of Bone IV. The Osteocytes V. Elementary Types of Bone VI. Higher Organization of Bone VII. Lamellation VIII. "Membrane" and "Cartilage" Bone and Bones IX. Evolution of Bone and Cartilage ReferencesChapter 2. The Osteoblast I. Introduction II. General Morphology III. Cytochemistry IV. The Functional Significance of Osteoblasts V. Origin of Osteoblasts ReferencesChapter 3. The Osteoclast I. Introduction II. Appearance III. Function IV. Mode of Action V. The Osteoclast and Parathyroid Hormone VI. Origin, Life-span, and Fate ReferencesChapter 4. Skeletal Tissue in Culture I. Introduction II. Historical Aspects III. Techniques for the Growth of Skeletal Elements in Vitro IV. Metabolism of Skeletal Tissue in Vitro V. Physiological and Pathological Effects of Vitamins and Hormones on Skeletal Tissue in Vitro VI. Effects of Miscellaneous Substances on Skeletal Tissue in Vitro VII. Conclusions and Outlook ReferencesChapter 5. The Organic Matrix of Bone I. Introduction II. The Chemical Composition of Bone III. The Chemistry of Bone Collagen IV. The Glycosaminoglycans (Acid Mucopolysaccharides) of Bone V. The Glycoproteins of Bone VI. The Lipids of Bone VII. The Peptides of Bone VIII. Molecular Interactions and Function ReferencesChapter 6. The Ultrastructure of Bone I. Introduction II. The Organic Matrix of Bone III. The Bone Mineral IV. The Relationship between Mineral and Matrix V. The Bone Cells ReferencesChapter 7. Aspects of the Molecular Structure of Bone I. Introduction II. The Inorganic Phase of Bone III. Macromolecular Organization of Apatite and Collagen IV. Concluding Remarks ReferencesChapter 8. Scanning Electron Microscope Studies of Bone I. Introduction II. The Scanning Electron Microscope III. Preparation of Bone Specimen for the Scanning Electron Microscope IV. Adult Bone V. Fetal Bone VI. Endochondral Ossification VII. Characteristics of Fractured Surfaces VIII. Discussion ReferencesChapter 9. Bone as a Mechanical Engineering Problem I. Introduction II. Shape and Size III. Growth of the Skull IV. Cancellous Bone V. Bone Strength VI. Microstrength of Bone VII. Hormonal Effects VIII. Nervous Influences on Bone IX. Strength of Healing Fractures ReferencesAuthor IndexSubject Index