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The Structure and Function of Nervous Tissue, Volume IV: Physiology II and Biochemistry II focuses on the structure and function of nervous tissue. It investigates the plasticity of synapses, their degeneration and regeneration, neuronal inclusions, RNA of nervous tissue, and molecular organization of neural information processing. Furthermore, it covers topics on gamma-aminobutyric acid (GABA) in the nervous system, the blood-brain barrier, and the extracellular space (ECS) in the vertebrate central nervous system (CNS). Organized into 10 chapters, this volume begins with an overview of synapses, with emphasis on changes in both the efficacy of individual synapses and the numbers of synapses made by axons upon neurons. It then discusses the orthograde terminal degeneration of synapses and the use of light and electron microscopy in studying synapse degeneration and regeneration. It also explains the synthesis, storage, and release of acetylcholine from nerve terminals; inclusions associated with viral infections; metabolism of RNA in nervous tissue; chemical correlates of information processing; metabolism of GABA in mammalian CNS; electrical activity of the normal brain; and chemistry of the cerebrospinal fluid. The book concludes with a chapter on the mechanism by which vertebrate central nervous tissue alters the magnitude of the ECS. This book will be of interest to anatomists, embryologists, biochemists, pathologists, clinicians, and molecular biologists. This will be invaluable as well to graduate students in a variety of disciplines and those specializing in particular aspects of nervous tissue study.
Language
Place of publication
Publishing group
Elsevier Science & Techn.
ISBN-13
978-0-323-14588-6 (9780323145886)
Schweitzer Classification
ContributorsPrefaceContents of Other Volumes1. Plasticity of Synapses I. Introduction II. Short-Term Functional Studies III. Short-Term Structural Studies IV. Trophic Effects at Synapses V. Long-Term Functional Studies VI. Long-Term Structural Studies VII. Conclusions References2. Degeneration and Regeneration of Synapses I. Introduction II. Degeneration of Synapses III. Regeneration of Synapses IV. Summary References3. Synthesis, Storage, and Release of Acetylcholine from Nerve Terminals I. Acetylcholine Synthesis II. Acetylcholine Storage III. Transmitter Release References4. Neuronal Inclusions I. Introduction II. Inclusions Associated with Viral Infections III. Nonviral Nuclear Inclusions IV. Nonviral Cytoplasmic Inclusions V. Inclusions Derived from Neuronal Fibrous Proteins References5. Ribonucleic Acid of Nervous Tissue I. General Aspects of RNA in Nervous Tissue II. RNA Metabolism III. Induced Changes in RNA IV. Special Considerations References6. Molecular Organization of Neural Information Processing I. Introduction II. Chemical Correlates of Information Processing III. Bioassays for the Molecular Code IV. Molecular Basis of Neural Coding V. Concluding Remarks References7. ?-Aminobutyric Acid in the Nervous System I. Introduction II. Early History III. Crustacean Neuromuscular Junction IV. Other Invertebrate Inhibitory Synapses V. Inhibitory Action of GABA in Nonmammalian Vertebrates VI. Inhibitory Synapses in Deiters Nucleus VII. Other Inhibitory Synapses in Mammalian CNS VIII. Metabolism of GABA in Mammalian CNS IX. Other Amino Acids Related to GABA X. General Comments and Conclusion References8. The Electrical Activity of the Normal Brain I. Introduction-The Phenomenon as Observed II. The EEG of Normal Man III. Neuronal Mechanisms Underlying the EEG IV. The Effect of Peripheral Stimulation on the Electrical Activity of the Brain V. Neuronal Mechanisms Underlying the Evoked Potential VI. Summary References9. The Blood-Brain Barrier I. Introduction II. Drainage of the Cerebrospinal Fluid-Arachnoid Villi III. The Secretion of the Cerebrospinal Fluid-Choroid Plexuses IV. Chemistry of the Cerebrospinal Fluid V. Rate of Secretion of Cerebrospinal Fluid VI. Passage of Infused Material from Blood to Cerebrospinal Fluid VII. Penetration into Brain VIII. Permeability of the Choroid Plexus IX. Slowly Equilibrating Substances X. Extracellular Space of Brain XI. Brain-Cerebrospinal Fluid Exchanges XII. Active Transport Outwards XIII. Morphology of the Blood-Brain Barrier XIV. Significance of the Blood-Brain Barrier XV. Mechanism of Homeostasis XVI. The Cerebrospinal Fluid and Brain Potentials XVII. Acid-Base Parameters XVIII. Some Special Features of the Blood-Brain Barrier System XIX. Modifications of the Barriers XX. Ontogeny of the Blood-Brain Barrier XXI. Special Regions of the Brain XXII. Peripheral Nerve Appendix References10. The Extracellular Space in the Vertebrate Central Nervous System I. Space Determinations with Extracellular Markers II. Electrical Impedance of Central Nervous Tissue III. Chloride and Water Movements in Central Nervous Tissue IV. Electron Microscopy of Central Nervous Tissue V. Mechanisms Involved in the Electrolyte and Water Transport in Central Nervous Tissue ReferencesAuthor IndexSubject Index