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The Biochemistry and Physiology of Bone, Second Edition: Volume III: Development and Growth focuses on bone development and growth, including bone repair and transplantation, the mechanisms of bone formation, and the role of hormones in bone formation and maintenance. It also explores osteogenesis in the human embryo and fetus, the internal remodeling and growth of bones, bone turnover and osteoporosis, cellular dynamics of bone, and the effects of radiation on bone. Organized into 12 chapters, this edition begins with an overview of the biophysical principles affecting bone structure, with emphasis on the direct and indirect effects of pressure on cells and the possible mechanisms by which cell behavior is controlled by bioelectrical responses. It then discusses the periosteal and endochondral ossification of cartilage bone, internal remodeling in the young adult skeleton, structural aspects of bone growth, and radioautographic studies of bone formation. It also explains the symptoms, diagnosis, and treatment of osteoporosis; histology of osteocytic resorption; tritiated thymidine studies in bone; induction of heterotopic bone formation; requirements for cell survival in free autologous transplants; and skeletal effects of ovarian steroids. The book concludes with a chapter on the effects of radiation on tissues closely related to bone. Biochemists, cell biologists, physiologists, anatomists, orthopedists, pathologists, clinicians, biomedical engineers, graduate students, professors, and others interested in the bone development and growth will find this book highly informative.
Edition
Language
Place of publication
Publishing group
Elsevier Science & Techn.
ISBN-13
978-0-323-16150-3 (9780323161503)
Schweitzer Classification
List of ContributorsPreface to Second EditionPreface to First EditionContents of Other VolumesChapter 1. Biophysical Principles Affecting Bone Structure I. Introduction II. Form and Function III. Bioelectrical Effects on Cells and Their By-products IV. Possible Mechanisms by Which Bioelectrical Responses Control Cell Behavior V. Summary ReferencesChapter 2. Osteogenesis in the Human Embryo and Fetus I. Introduction II. Ossification and Growth III. Development of Specific Bones IV. Onset and Sequence of Ossification V. General Considerations of Bone Development ReferencesChapter 3. The Internal Remodeling of Bones I. Introduction II. The Internal Remodeling in the Young Adult Skeleton III. The Internal Remodeling in the Growing Skeleton IV. The Internal Remodeling in the Aging Skeleton V. The Significance of the Internal Remodeling ReferencesChapter 4. The Growth of Bone I. Body Growth and Bone Growth II. Structural Aspects of Bone Growth III. Physiological Control of Normal Bone Growth IV. Bone Growth under Pathological Conditions V. Conclusions ReferencesChapter 5. Radioautographic Studies of Bone Formation I. General Introduction II. Historical Introduction III. The Growing Osteon of Long Bones in Dogs as a Model for the Formation of Bone Tissue IV. Biosynthesis of the Organic Bone Matrix-Collagen Formation V. Biosynthesis of the Organic Bone Matrix-Mucopolysaccharide and Glycoprotein Formation VI. Acquisition of Minerals by Bone Tissues VII. Conclusions ReferencesChapter 6. Bone Turnover and Osteoporosis I. Introduction II. Osteopenias Associated with Known Abnormalities III. Bone Turnover IV. The Osteoporotic Patient V. Osteoporosis and Osteomalacia VI. Osteoporosis and Secondary and "Primary" Hyperparathyroidism VII. Treatment of Osteoporosis ReferencesChapter 7. Osteocytic Resorption I. Introduction II. Historical Review III. Technical Approaches IV. Cementolysis V. The Place of Osteolysis in Bone Physiology VI. Objection VII. Enlarged Lacunae without Osteolysis VIII. Osteocytic Resorption among Vertebrates IX. Factors Which Promote Osteocytic Resorption X. Adverse Factors XI. Osteocytic Resorption in Human and Animal Pathology ReferencesChapter 8. Cellular Dynamics of Bone I. Introduction II. Compartments of Bone Cells III. Bone Surfaces IV. Cellular Nomenclature V. Cell Kinetics VI. Tritiated Thymidine Studies in Bone VII. The Effect of Different Agents on Cellular Dynamics VIII. Other Studies IX. Concluding Remarks ReferencesChapter 9. Induction of Heterotopic Bone Formation I. Introduction II. Description of the Existing Experimental Systems III. The Nature of the Inductive Agent IV. Transplantological Problems V. Conclusions ReferencesChapter 10. Repair and Transplantation of Bone Part 1. The Repair of Bone I. Introduction II. The General Features of a Bone and the Location of the Various Members of the Bone Cell Lineage in Its Substance and on Its Surfaces III. The Morphology and Behavior following a Fracture of the Members of the Bone Cell Lineage IV. Fracture Healing in Man Part 2. The Transplantation of Bone I. Introduction II. The Requirements for Cell Survival in Free Autologous Transplants III. Transplants of Autologous Compact Bone IV. Transplants of Homologous Compact Bone V. Transplants of Autologous Cancellous Bone VI. Transplants of Homologous Cancellous Bone VII. The Types of Grafts Used in Some Common Clinical Conditions VIII. Studies on the Transplantation of Epiphyseal Plates ReferencesChapter 11. Steroid Hormones and Bone I. Introduction II. Scope of the Problem III.