Aspects of Cell Regulation

ContributorsPrefaceSupplements in SeriesCellular Factors Which Modulate Hormone Responses: Glucocorticoid Action in Perspective I. Introduction II. Cell Entry III. Steroid-Receptor Interaction IV. Receptor Activation and Nuclear Translocation V. Nuclear Binding Sites of the Steroid-Receptor Complex VI. Mechanism of Gene Activation VII. Summary ReferencesRegulation of Genetic Activity by Thyroid Hormones I. Introduction II. Thyroid Hormones Participate in Cell Differentiation via Regulation of Nucleic Acid and Protein Syntheses III. Binding of Thyroid Hormones to the Nuclear Receptor IV. Binding of Thyroid Hormones to the Cytoplasmic Receptor V. Binding of Thyroid Hormones to Other Intracellular Components VI. Major Working Hypothesis on the Mechanisms of Genetic Activity Regulation by Thyroid Hormones VII. Properties of the Thyroxine Cytoplasmic Receptor VIII. The Role of the Thyroxine Cytoplasmic Receptor in Translocation of the Hormone from the Nucleus and Acceptance by Chromatin IX. The Cytoplasmic Receptor as Mediator for the Action of Thyroid Hormones in the Nucleus X. Interaction of the Hormone-Receptor Complex with DNA XI. The TBPA-like Cytosol Receptor is a Universal Intracellular Receptor of Thyroid Hormones ReferencesThe Partitioning of Cytoplasmic Organelles at Cell Division I. Introduction II. A Note on Terminology: Segregation and Partitioning III. Numerical Partitioning of Organelles IV. Compensating Replication V. Numerical Partitioning of Organelle DNA VI. Genetic Partitioning of Organelles VII. Summary ReferencesCell Cycle Mutants I. Introduction II. Cell Cycle Concept III. Cell Cycle Mutants IV. Future Considerations V. Conclusions ReferencesFormation of Glyoxysomes I. Introduction II. Characterization of Glyoxysomes III. Origin of Glyoxysomal Components IV. General Conclusions ReferencesMitochondria, Cell Surface, and Carcinogenesis I. Introduction II. The Mitochondrial System III. Tumor Mitochondria IV. Antimitochondrial Activity of Carcinogens V. Mitochondria and Cell Surface Characteristics VI. Mitochondria and Intracellular Systems VII. Mechanism of Mitochondrial Control VIII. Conclusions and Prospects ReferencesTransforming Genes of Tumor Cells I. Demonstration of Altered DNA in Nonvirally Transformed Cells II. Transforming DNA of Tumors Induced by Slowly Oncogenic Viruses III. The Discrete Nature of These Transforming Sequences IV. The Discovery of Tissue-Specific Oncogenes V. Isolation of Active Oncogenes VI. The Relationship of These Tumors to Other Known Oncogenes VII. Additional Roles of one Genes VIII. Perspectives ReferencesViral Carcinogenesis I. Introduction II. Oncogenic DNA Viruses III. Retroviruses ReferencesThe Origin of Viruses from Cells I. Introduction II. Historical III. Mechanisms for Change in Viruses IV. The Evolutionary Age of Viruses V. The Kinds of Cells VI. The Kinds of Viruses VII. Chlamydiae and Viruses Compared VIII. Would a Cell ¿ Virus Transition Be Possible? IX. Origin of Viruses from Cellular Genetic Elements X. Conclusions ReferencesIndex