
Medical Toxicology of Occupational and Environmental Exposures, Volume 3
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Medical Toxicology of Occupational and Environmental Exposures is the only reference which comprehensively covers the clinical, analytical, and monitoring information needed by clinicians, students and investigators with interests in metals, radiation, and cancer. The information in all chapters is presented in a cogent, standardized format which greatly simplifies the use of the text as a reference. Reviewed by a distinguished panel of well-known toxicology experts, the information is critically evaluated and authoritative. The interdisciplinary, evidence-based approach is designed to reach beyond clinical settings to increase the scientific understanding of those in associated fields (analytical laboratories, universities, federal and state regulatory and environmental agencies) involved with decisions regarding metals, radiation, and chemical carcinogens. The consistent and concise style allows the reader to quickly locate the appropriate information necessary for informed decisions regarding the sources, host susceptibility, dose-response, clinical effect, health surveillance, and management of exposures to these substances. Additional information is readily available to the interested reader through the detailed bibliography at the end of each chapter.
- Volume 3 "Carcinogens, Risk Factors, Pathophysiology, Susceptibility, and Clinical Abnormalities" provides concise, comprehensive coverage of the genetic background and an organ-based approach to cancer-causing exposures, histology, host susceptibility, and clinical features.
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Persons
Donald G. Barceloux, MD, Author: Dr. Barceloux is a Medical Toxicologist in the Department of Emergency Medicine at Pomona Valley Community Hospital. For over 20 years, he served as a Clinical Professor of Medicine at the Olive View/University of California, Los Angeles School of Medicine Department of Emergency Medicine. He received his A.B. in Biology, B.S. in General Engineering, and M.S. in Engineering Science from Stanford University, and his medical training at the University of California, Los Angeles. He is a Consultant in Medical Toxicology including the diagnosis and treatment of poisoning, health surveillance, biological monitoring, interpretation of risk assessment and toxicological data, and determination of the medical effects of exposures to chemicals and drugs. He co-authored the First Edition of Medical Toxicology: Diagnosis and Treatment of Human Poisoning as well as various other toxicology related publications on metals, solvents, alcohols, natural substances, drugs of abuse, and the treatment of poisonings. This volume is the third book in his Medical Toxicology series, which provides concise, detailed coverage on the medical toxicology of metals, radiation, and chemical carcinogens. The first two volumes were Medical Toxicology of Natural Substances: Foods, Fungi, Medicinal Herbs, Plants, and Venomous Animals and Medical Toxicology of Drug Abuse: Synthetic Chemicals and Psychoactive Plants. His work in Medical Toxicology and Emergency Medicine has been recognized by fellowship in the American Academy of Clinical Toxicology, the American College of Medical Toxicology, and the American College of Emergency Medicine.
Robert B. Palmer, PhD, Editor: Dr. Palmer is a board-certified clinical toxicologist in private practice with Toxicology Associates, PLLC and is an attending toxicologist at the Rocky Mountain Poison and Drug Service in Denver, CO. He holds academic appointments at the University of Colorado and University of Wyoming. Dr. Palmer previously served on the Board of Directors of the American Board of Applied Toxicology (ABAT) and the Board of Trustees of the Academy of Clinical Toxicology (AACT) including serving as AACT president. He is a frequent author and speaker on many aspects of clinical and forensic toxicology.
Content
PREFACE xxiii
ACKNOWLEDGMENTS xxv
REVIEW PANEL xxv
VOLUME 3 CARCINOGENS: RISK FACTORS, PATHOPHYSIOLOGY, SUSCEPTIBILITY, and CLINICAL ABNORMALITIES 1
A CARCINOGENESIS 3
47 CARCINOGENESIS 5
B CHEMICAL CARCINOGENICITY 57
48 GENERAL PRINCIPLES 59
49 EVALUATING CARCINOGENICITY 75
50 CARCINOGEN CLASSIFICATIONS 151
51 RISK ASSESSMENT 169
52 CANCER SURVEILLANCE 203
C TUMOR SITES 217
53 RESPIRATORY TRACT 219
54 GASTROINTESTINAL TRACT 273
55 URINARY TRACT 337
56 MALE REPRODUCTIVE TRACT 365
57 FEMALE REPRODUCTIVE TRACT 391
58 CENTRAL NERVOUS SYSTEM 441
59 LEUKEMIA 483
60 LYMPHOMAS 539
61 SKIN 629
62 SOFT TISSUE AND BONE SARCOMAS 667
63 THYROID 691
INDEX 705
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