DNA Microarrays and Gene Expression
From Experiments to Data Analysis and Modeling
1st Edition
Published on 2. December 2004
978-0-511-05688-8 (ISBN)
Description
Massive data acquisition technologies, such as genome sequencing, high-throughput drug screening, and DNA arrays are in the process of revolutionizing biology and medicine. Using the mRNA of a given cell, at a given time, under a given set of conditions, DNA microarrays can provide a snapshot of the level of expression of all the genes in the cell. Such snapshots can be used to study fundamental biological phenomena such as development or evolution, to determine the function of new genes, to infer the role individual genes or groups of genes may play in diseases, and to monitor the effect of drugs and other compounds on gene expression. Originally published in 2002, this inter-disciplinary introduction to DNA arrays will be of value to anyone with an a interest in this powerful technology.
Reviews / Votes
Review of the hardback: 'The book, written by Baldi and Hatfield, is an important and timely addition to the DNA microarray literature ... the first several chapters of the book provide an easy-to-digest overview of the current state of DNA microarrays.' Briefings in Functional Genomics & Proteomics Review of the hardback: 'Writing a book such as this was a challenging remit and one that the authors have achieved with great success.' Human Genomics Review of the hardback: 'I recommend very highly this book to statisticians in particular.' Journal of Statistical Computation & SimulationMore details
Language
English
Place of publication
Cambridge
United Kingdom
Publishing group
Cambridge University Press
Target group
Professional and scholarly
Illustrations
Worked examples or Exercises
File size
2,52 MB
ISBN-13
978-0-511-05688-8 (9780511056888)
Copyright in bibliographic data and cover images is held by Nielsen Book Services Limited or by the publishers or by their respective licensors: all rights reserved.
Schweitzer Classification
Other editions
Additional editions
Pierre Baldi | G. Wesley Hatfield
DNA Microarrays and Gene Expression
From Experiments to Data Analysis and Modeling
Book
04/2011
Cambridge University Press
€54.40
Shipment within 15-20 days
Pierre Baldi | G. Wesley Hatfield
DNA Microarrays and Gene Expression
From Experiments to Data Analysis and Modeling
Book
09/2002
Cambridge University Press
€56.95
Article exhausted; check for reprint
Persons
Pierre Baldi is Professor and Director of the Institute for Genomics and Bioinformatics in the Department of Information and Computer Science and in the Department of Biological Chemistry in the College of Medicine at the University of California, Irvine. Wes Hatfield is a Professor in the Department of Microbiology and Molecular Genetics in the College of Medicine and the Department of Chemical Engineering and Material Sciences in the School of Engineering at the University of California, Irvine.
Content
Preface; 1. A brief history of genomics; 2. DNA array formats; 3. DNA array readout methods; 4. Gene expression profiling experiments: problems, pitfalls and solutions; 5. Statistical analysis of array data: inferring changes; 6. Statistical analysis of array data: dimensionality reduction, clustering, and regulatory regions; 7. Survey of current DNA array applications; 8. Systems biology: overview of regulatory, metabolic and signaling networks.
