Fundamentals of Radiobiology
International Series of Monographs in Pure and Applied Biology: Modern Trends in Physiological Sciences
2nd Edition
Published on 22. October 2013
576 pages
978-1-4831-8452-4 (ISBN)
Description
Fundamentals of Radiobiology presents a clear picture of the effects of radiation to living organisms. It discusses the steps leading from the absorption of energy to death or final injury. The focus of study is the changes induced at the molecular level by absorbing energy. Some of the topics covered in the book are the methods for determining the direct and indirect action in biological systems, the nature of the initial chemical lesion in cellular radiobiology, the definition of target theory and the meaning of poison theory. The subjects on general radiation chemistry are also covered. The fields of radiation chemistry that will be discussed are the role of excitation, the variation of reactions between gases, liquids, and solids; and the status of free radicals created. The effects of radiation on macromolecules are discussed. The text defines the important role of metabolism in the development of the lesions. An analysis of the interactions of ionizing radiations with is presented. A chapter of the volume is devoted to the radiation chemistry of aqueous systems. Another section of the book focuses on the chemicals which simulate the biological effects of ionizing radiations. The book will provide useful information to doctors, chemists, biologists, radiologists, students and researchers.
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Zenon Marcel Bacq
Fundamentals of Radiobiology
Book
12/1961
2nd Edition
Pergamon
€148.56
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Content
ForewordIntroduction-The Stepwise Development of Radiation InjuryChapter 1. Interaction of Ionizing Radiations with Matte Comparison of the Different Radiations Mechanism of Energy Loss by X- And Y-Radiations Energy Loss by Particulate Radiations Units of Radiation Dose and Radioactivity Measurement of Dose Ionization Density Excitations Produced by Ionizing RadiationChapter 2. Direct and Indirect Action in Biological Systems Methods For Distinguishing Between Direct And Indirect Action Relative Effectiveness of Direct and Indirect Action in Vitro Relative Effectiveness of Direct and Indirect Action in CellsChapter 3. Dose-Response Relationships in Chemical and Biological Systems The D 3 7 Dose and "Single-Hit" Concept "Multi-Hit" Effects Threshold-A Problem of Mammalian RadiobiologyChapter 4. The Nature of the Initial Chemical Lesion in Cellular Radiobiology The Target Theory Application of Target Theory to Radiation Effects Produced In Vivo The Relative Biological Effectiveness of Different Ionizing Radiations The Poison Theory ConclusionsChapter 5. General Radiation Chemistry Role Of Excitation Difference Between the Reactions in Gases and Those in Liquids and Solids Protection and Energy Transfer Fate of Free Radicals ProducedChapter 6. The Radiation Chemistry of Aqueous Systems Introduction Historical Development Primary Products in the Radiolysis of Water Reactions of Free Radicals Reactions of Organic Substances Dissolved in WaterChapter 7. Effect of Radiation on Macromolecules Radiation Changes in Synthetic Polymers Produced by Indirect Action Radiation Changes in Synthetic Polymers Produced by Direct Action Protection of Molecules Physical and Chemical Changes Produced in Proteins by Direct Action Physical and Chemical Changes in Proteins Produced by Indirect Action Crosslinking And Degradation of Deoxyribonucleic Acid Changes Produced in Dna Following Irradiation In Vivo Changes Produced in Polysaccharides The Use Of Radiation as an Analytical ToolChapter 8. Chemical Substances WhichH Simulate the Biological Effect* of Ionizing Radiations The Chemistry of The Biological Alkylating Agents Comparison of Biological Effects Produced By The Alkylating Agents And By Radiations Mechanism of Action Of The Alkylating Agents Radiomimetic Properties Of Peroxides and Oxygen at High ConcentrationsChapter 9. Effects at the Cellular Level Introduction Mitosis Meiosis Mitosis in a Complex Organism Reversible Cell Damage and Mitotic Delay Cell Death Breakage of Chromosomes Genetic Effects of Ionizing RadiationsChapter 10. Biochemical Mechanism for Cellular Effects-The Enzyme Release Hypothesis Nucleus Versus Cytoplasm Chromosome Breakage Interruption of Energy Supply The Enzyme-Release HypothesisChapter 11. The Effect of Oxygen in Radiobiology Time at Which Oxygen Acts Concentration of Oxygen Required The Oxygen Effect in Mammals Application of Oxygen Effect to Radiotherapy Mechanism of ActionChapter 12. Comparative Radiosensitivity of Living OrganismsChapter 13. Pathological Biochemisty of Irradiated Living Organisms Oxygen Consumption Carbohydrate Metabolism After Irradiation Disturbances in Fat Metabolism Protein Metabolism Changes in Electrolyte Concentration Sulphydryl Enzymes and Proteins Increased Enzymic and Synthetic Activity After Irradiation Inhibition of Isolated Enzyme Systems In Vivo Biosynthesis of Nucleic Acids Mechanisms Responsible for Decreased Biosynthesis of DNA and RNA The Nucleases SummaryChapter 14. Processes of Restoration After Irradiation Restoration of Genetic Damage and of Reproductive Capacity Recovery from Physiological Injuries Repair In MammalsChapter 15.
