Current Topics in Membranes and Transport
Published on 17. June 1986
312 pages
978-0-08-058497-3 (ISBN)
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Current Topics in Membranes and Transport
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Felix Bronner | A. Kleinzeller
Current Topics in Membranes and Transport: v. 26
Book
01/1986
Academic Press
€131.23
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Content
- Front Cover
- Na+ -H+ Exchange, Intracellular pH, and Cell Function
- Copyright Page
- Contents
- Preface
- Yale Membrane Transport Processes Volumes
- PART I: GENERAL ASPECTS OF INTRACELLULAR pH REGULATION AND Na+-H+ EXCHANGE
- Chapter I. lntracellular pH Regulation by Leech and Other Invertebrate Neurons
- I. Introduction
- II. Methods
- III. Results with Leech Neurons
- IV. Conclusion
- References
- Chapter 2. Approaches for Studying lntracellular pH Regulation in Mammalian Renal Cells
- I. Introduction
- II. An Optical Absorbance Technique for Measuring lntracellular pH
- III. lntracellular pH Regulation in Mammalian Renal Cells
- IV. Conclusions
- References
- Chapter 3. Aspects of pHi Regulation in Frog Skeletal Muscle
- I. Introduction
- II. Methods
- Ill. Steady-State pH
- IV. Response of pH1 to Acid Loading
- V. Nature of pH1-Regulating Systems
- VI. Properties of Na-H Exchange
- VII. Factors Affecting the Rate of Na-H Exchange
- VIII. Comparison with Other Cells
- IX. Summary
- References
- Chapter 4. Molecular Properties and Physiological Roles of the Renal Na+-H + Exchanger
- I. Introduction
- II. Kinetics of the Renal Nat-H+ Exchanger
- Ill. Biochemistry of the Renal Na+-H+ Exchanger
- IV. Role of the Renal Na+-Ht Exchanger in Facilitating Anion Transport
- References
- PART II. Na+-H+ EXCHANGE AND CELL VOLUME REGULATION
- Chapter 5. Volume-Sensitive Alkali Metal-H Transport in Amphiuma Red Blood Cells
- I. Introduction
- II. Volume-Sensitive Fluxes in Amphiuma Red Blood Cells
- Ill. The Effects of DlDS upon Alkali Metal-H Exchange by Osmotically Swollen Cells: Activation versus Altered Selectivity
- IV. Activation of Alkali Metal-H Exchange: A Role for Diacylglycerol through Protein Kinase C
- V. The Relationship between Na-H and K-H Exchange in Amphiuma Red Blood Cells
- VI. Summary
- References
- Chapter 6. Na-Proton Exchange in Dog Red Blood Cells
- I. Introduction
- II. Anion Requirement
- III. Fixation of the Transport Mechanism by Glutaraldehyde
- IV. Protein Fluxes
- V. Lithium Effects
- References
- Chapter 7. Activation of the Na+-H+ Antiport by Changes in Cell Volume and by Phorbol Esters
- Possible Role of Protein Kinase
- I. Introduction
- II. Basic Properties of Na+-Ht Exchange in Lymphocytes
- III. Na+-H+ Exchange in Volume Regulation
- IV. Stimulation of Na+-H+ Exchange by Phorbol Esters
- V. Similarities of the Phorbol Ester and Volume-Induced Activation
- VI. Possible Involvement of a Protein Kinase in Volume Regulation
- VII. Osmotically Induced Changes in Phosphoinositide Turnover
- VIII. Concluding Remarks
- References
- PART III: Na+-H+ EXCHANGE AND CONTROL OF CELL GROWTH
- Chapter 8. The Generation of Ionic Signals by Growth Factors
- I. Introduction
- II. Ionic Signals in Growth Factor Action
- III. Possible Physiological Role of Inlracellular Ionic Changes
- IV. A Monoclonal Antibody Approach to the Dissociation of Early Events in EGF Action
- V. Concluding Remarks
- References
- Chapter 9. Control of Mitogenic Activation of Na+-H+ Exchange
- I. Introduction
- II. The Activation of Na+-H+ Antiport in A431 Epidermoid Carcinoma Cells and NR6 Fibroblasts
- References
- Chapter 10. Mechanisms of Growth Factor Stimulation of Na+-H+ Exchange in Cultured Fibroblasts
- I. Introduction
- II. Stimulation of Na+ Influx in HSWP Cells by Serum and Peptide Mitogens
- III. Characterization of the Transport System Mediating Mitogen-Stimulated Na+ Influx
- IV. Involvement of Ca2+ in the Mitogen Activation of the Na+-H+ Exchanger
- V. Possible Role of Protein Kinase C in The Activation of Na+ Exchange in Hswp Cells and Other Fibroblast Systems
- VI. Evidence for Phospholipase Involvement in the Mitogen Activation of Na+-H+ Exchange in HSWP Cells
- VII. Possible Involvement of Phospholipases in the Mobilization of Intracellular Ca2+
- VIII. Which Phospholipase Is Activated by Mitogen Stimulation?
- IX. Summary of the Proposed Mechanism for Activation of the Na+-H+ Exchanger by Mitogens
- References
- Chapter 11. B Lymphocyte Differentiation: Role of Phosphoinositides, C Kinase, and Na+-H+ Exchange
- I. Introduction
- II. Effects of Lipopolysaccharide on Phosphatidylinositol Turnover and Cytosolic Free Ca2+
- III. Effects of Phorbol Esters on Phosphatidylinositol Turnover and Cytosolic Free Ca2+
- IV. Conclusion
- References
- Chapter 12. Na+-H+ Exchange and Growth Control in Fibroblasts: A Genetic Approach
- I. Introduction
- II. Fibroblast Mutants Altered in the Na+-H+ Antiport Activity
- III. Characterization and Properties of Two pH1-Regulating Systems in Fibroblasts
- IV. Growth Factor Activation of the Na+-H+ Antiporter
- V. pH1 Controls Reinitiation of DNA Synthesis and Growth
- VI. Toward a Molecular Identification of the Na+-H+ Antiport System
- VII. Conclusions
- References
- PART IV: ROLE OF Na+-H+ EXCHANGE IN HORMONAL AND ADAPTIVE RESPONSES
- Chapter 13. Hormonal Regulation of Renal Na+-H+ Exchange Activity
- I. Introduction.
- II. Functions of Na+-H+ Exchange in the Proximal Tubule
- III. Measurement of Na+-H+ Exchange Activity in Renal Brush Border Membrane Vesicles
- IV. Extrinsic Effectors of Renal Na+-H+ Exchange Activity
- V. Hierarchy of Hormonal Effect of Na+-H+ Exchange,
- References
- Chapter 14. Adaptation of Na+-H+ Exchange in the Proximal Tubule: Studies in Microvillus Membrane Vesicles
- I. Introduction
- II. Experimental Approach
- III. Effects of Uninephrectomy and Dietary Protein on Na+-H+ Exchange
- IV. Effects of Potassium Depletion on Na+-H+ Exchange
- V. Other Models of Adaptation
- VI. Summary and Conclusions
- References
- Chapter 15. The Role of lntracellular pH in Insulin Action and in Diabetes Mellitus
- I. Introduction
- II. Mechanism of Insulin Effect upon pH1
- III. Effects of Insulin-Mediated Changes in pH1 upon Glycolysis
- IV. Role of lntracellular pH in Insulin Action
- V. Model of Ionic Part of Mechanism of Insulin Action
- VI. Clinical Implications
- References
- Chapter 16. The Proton as an Integrating Effector in Metabolic Activation
- I. Introduction
- II. Four Systems Involving Regulatory pH1 Changes
- III. Comparison of in Vitro pH/Activity Profiles with in Vivo Responses
- IV. Conclusion: Why Use pH1 as a Metabolic Regulator'?
- References
- Index
