Drugs
Photochemistry and Photostability
1st Edition
Published on 31. October 2007
334 pages
978-1-84755-071-2 (ISBN)
Description
Since Pasteur in 1846, scientists have been aware that many drugs are photoreactive, but until recently research in this area had been somewhat limited. However, since the introduction of acutely sensitive analytical methods, the realisation of the need to identify the photochemical properties of a potential drug as early in its development as possible and the increased attention to the phototoxic effect of drugs, more details are becoming available. Drugs: Photochemistry and Photostability presents the basic elements of the science, and serves as an excellent introduction to this emerging field of photochemistry. Detailed experimental conditions for photostability studies are given, along with a discussion of the recently implemented ICH Guidelines for drug photostability. With contributions from international experts in the field and including a comprehensive literature review, this book provides all the up-to-date information needed by researchers in many fields, especially medicinal and pharmaceutical chemistry.
More details
Series
Edition
1. Auflage
Language
English
Place of publication
Cambridge
United Kingdom
Target group
Professional and scholarly
ISBN-13
978-1-84755-071-2 (9781847550712)
DOI
10.1039/9781847550712
Copyright in bibliographic data and cover images is held by Nielsen Book Services Limited or by the publishers or by their respective licensors: all rights reserved.
Schweitzer Classification
Other editions
Additional editions
Book
08/1998
Royal Society of Chemistry
€103.50
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Persons
Content
Photochemistry of Drugs: An Overview and Practical Problems;
Medicinal Photochemistry (An Introduction with Attention to Kinetic Aspects);
Photoreactivity of Selected Antimalarial Compounds in Solution and in the Solid State;
Photochemistry of Diuretic Drugs in Solution;
New Results in the Photoinstability of Antimycotics;
Photoreactivity versus Activity of a Selected Class of Phenothiazines: A Comparative Study;
Photoprocesses in Photosensitising Drugs containing a Benzophenone-like Chromophore;
Photostability of Coumarin;
Photostabilities of Several Chemical Compounds used as Active Ingredients in Sunscreens;
An Analytical and Structural Study of the Photostability of some Leukotriene B4 Antagonists;
Molecular Mechanisms of Photosensitization Induced by Drugs on Biological Systems and Design of Photoprotective Systems;
A Comparison between the Photochemical and Photosensitising Properties of Different Drugs;
Photostability of Drug Substances and Drug Products: A Validated Reference Method for Implementing the ICH Photostability Study Guidelines;
The Elaboration and Application of the ICH Guideline on Photostability. A European View;
Selecting the Right Source for Pharmaceutical Photostability Testing;
Design and Validation Characteristics of the Environmental Chambers for Photostability Testing;
Design Limits and Qualification Issues for Room-size Solar Simulators in a GLP Environment;
Actinometry: Concepts and Experiments;
trans-2-Nitrocinnamaldehyde as Chemical Actinometer for the UV-A Range in Photostability Testing of Pharmaceuticals;
Subject Index.
Medicinal Photochemistry (An Introduction with Attention to Kinetic Aspects);
Photoreactivity of Selected Antimalarial Compounds in Solution and in the Solid State;
Photochemistry of Diuretic Drugs in Solution;
New Results in the Photoinstability of Antimycotics;
Photoreactivity versus Activity of a Selected Class of Phenothiazines: A Comparative Study;
Photoprocesses in Photosensitising Drugs containing a Benzophenone-like Chromophore;
Photostability of Coumarin;
Photostabilities of Several Chemical Compounds used as Active Ingredients in Sunscreens;
An Analytical and Structural Study of the Photostability of some Leukotriene B4 Antagonists;
Molecular Mechanisms of Photosensitization Induced by Drugs on Biological Systems and Design of Photoprotective Systems;
A Comparison between the Photochemical and Photosensitising Properties of Different Drugs;
Photostability of Drug Substances and Drug Products: A Validated Reference Method for Implementing the ICH Photostability Study Guidelines;
The Elaboration and Application of the ICH Guideline on Photostability. A European View;
Selecting the Right Source for Pharmaceutical Photostability Testing;
Design and Validation Characteristics of the Environmental Chambers for Photostability Testing;
Design Limits and Qualification Issues for Room-size Solar Simulators in a GLP Environment;
Actinometry: Concepts and Experiments;
trans-2-Nitrocinnamaldehyde as Chemical Actinometer for the UV-A Range in Photostability Testing of Pharmaceuticals;
Subject Index.
