Advances in Protein Chemistry
Academic Press
Published on 19. July 1993
217 pages
978-0-08-058217-7 (ISBN)
Description
Advances in Protein Chemistry
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07/1993
Academic Press
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Content
- Front Cover
- Accessory Folding Proteins
- Copyright Page
- Contents
- Preface
- Chapter 1. Mechanism of Enzymatic and Nonenzymatic Prolylcis-trans lsomerization
- I. Introduction
- II. Nonenzymatic Prolyl Isomerization
- III. Enzymatic Prolyl Isomerization
- IV. Mechanism of Enzymatic Prolyl Isomerization: Catalysis by Distortion
- References
- Chapter 2. Prolyl lsomerases: Role in Protein Folding
- I. Introduction
- II. Prolyl Isomerization
- III. Prolyl Isomerases
- IV. RNase T1 as Model System to Probe Catalysis of Folding
- V. Catalysis of Folding in Absence of Disulfide Bonds
- VI. Catalysis of Prolyl Isomerization during Unfolding and Refolding
- VII. Simultaneous Action of Prolyl Isomerase and Protein Disulfide-Isomerase as Catalysts of Folding
- VIII. Role of Prolyl Isomerase for Cellular Folding
- IX. Conclusions
- References
- Note Added in Proof
- Chapter 3. Structure and Mechanism of 70-kDa Heat-Shock-Related Proteins
- I. Overview of Stress-70 Proteins
- II. Biochemical Activities of Stress-70 Proteins
- III. Structure of Stress-70 Proteins
- IV. Enzymatic Mechanism of Stress-70 Proteins
- V. Modulators of Stress-70 Protein Activity
- VI. Epilogue
- References
- Chapter 4. PapD and Superfamily of Periplasmic Immunoglobulin-like Pilus Chaperones
- I. General Perspective
- II. Introduction
- III. pap Gene Cluster
- IV. Postsecretional Assembly
- V. Summary
- References
- Note Added in Proof
- Chapter 5. Protein Disulfide-lsomerase: Role in Biosynthesis of Secretory Proteins
- I. Introduction
- II. Catalytic Properties of Protein Disulfide-Isomerase
- III. Cellular Properties of Protein Disulfide-Isomerase
- IV. Role of Protein Disulfide-Isomerase in Intracellular Protein Folding
- V. Multifunctionality of Protein Disulfide-Isomerase
- VI. Conclusions
- References
- Chapter 6. SecB: A Molecular Chaperone of Escherichia coli Protein Secretion Pathway
- I. Overview
- II. Introduction
- III. Precursor Conformation Governing Signal Peptide Function
- IV. SecB as Component of Secretion Machinery
- V. Properties of SecB
- VI. SecB and Its Ligands Forming Isolable Complexes
- VII. Nature of SecB Binding Sites
- VIII. Other Chaperones and Protein Secretion
- IX. Recapitulation and Speculation
- References
- Author Index
- Subject Index
