
Advances in Protein Chemistry
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Content
- Front Cover
- Metalloproteins: Structural Aspects
- Copyright Page
- Contents
- Preface
- Chapter 1. Structural Aspects of Metal Liganding to Functional Groups in Proteins
- I. Metal-Binding Sites in Proteins
- II. Polarizabilities of Metals and Ligands
- III. Redox Behavior of Metal Ions
- IV. Number of Atoms Packed in First Coordination Sphere around Metal Ion
- V. Metal-Ligand Bond Distances
- VI. Asymmetry in Ionic Shape
- VII. Strengths of Bonds from Metal Ions to Ligands
- VIII. Selection of Metal Ions for Complexation
- IX. Metal Binding to Isolated Carboxylate Groups
- X. Metal Binding to Imidazole Groups
- XI. Metal Binding to Sulfur-Containing Groups.
- XII. Metal Binding to Main-Chain Carbonyl Groups
- XIII. Metal Binding to Two Groups
- XIV. Metals in Protein Crystal Structures
- XV. Electron Transfer in Metalloproteins
- XVI. Metal Competition and Replacement
- References
- Chapter 2. Calcium Binding Sites in Proteins: A Structural Perspective
- I. Introduction
- II. Functional and Structural Overview of Protein Ca2+-Binding Sites
- III. Regularities and Recurrent Themes in Ca2+-Binding Sites
- IV. Discussion and Summary
- References
- Chapter 3. Copper Protein Structures
- I. Introduction
- II. Cupredoxins: Proteins That Bind Only Type I Copper
- III. Proteins That Bind Only Type II Copper
- IV. Proteins That Bind Only Type III Copper
- V. Proteins That Bind More Than One Type of Copper
- VI. Summary and Conclusions
- References
- Chapter 4. Perspectives on Non-heme Iron Protein Chemistry
- I. Introduction
- II. Structures and Functions of Mononuclear Iron Proteins
- III. Structures and Mechanisms of Binuclear Octahedral Iron Proteins
- IV. Tetrahedral Iron: Fe:S Proteins
- V. Conclusions
- References
- Chapter 5. Structural Biology of Zinc
- I. Introduction
- II. Stereochemistry of Biological Zinc-Ligand Interactions
- III. Long-Range Protein-Metal Interactions
- IV. Examples of Zinc in Biological Catalysis and Regulation
- V. Protein Engineering of Zinc-Binding Sites
- VI. Summary
- References
- Author Index
- Subject Index
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