Advances in Pharmacology
Academic Press
Published on 1. January 1966
389 pages
978-0-08-058094-4 (ISBN)
Description
Advances in Pharmacology
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Silvio Garattini
Advances in Pharmacology: v. 4
Book
10/1966
Academic Press
€90.52
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Content
- Cover
- Contents
- Contributors
- Chapter 1. Hypotensive Peptides: Bradykinin, KalMin, and Eledoisin
- I. Introduction
- II. Releasing Enzymes (Kininogenases)
- III. Kininogen (Kallidinogen, Bradykininogen)
- IV. Kinins (Bradykinin, Kallidin, Met-Lys-Bradykinin)
- V. Eledoisin
- VI. Conclusions
- References
- Chapter 2. Uricosuric Drugs, with Special Reference to Probenecid and Sulfinpyrazone
- I. Uricosuric Activity Defined
- II. Physiological Basis for Use of Uricosuric Drugs
- III. Nature of Uricosuric Response in Normal and Gouty Man
- Species-Dependency
- IV. The Search for a Suitable Uricosuric Agent
- V. The Akylsulfonamidobenzoic and N-Alkylsulfamylbenzoic Acids
- VI. The Pyrazolidinediones
- VII. Incidental Compounds Possessing Uricosuric Properties: Phenolsulfonphthalein, Mersalyl, Iodopyracet, Corticotropin and Adrenocortical Steroids, Coumarins and Indandiones, Chlorprothixene, Acetohexamide, Ethyl-p-chlorophenoxyisobutyrate. The Paradoxical Action of Benzothiadiazines
- References
- Chapter 3. Synthetic Anti-Inflammatory Drugs: Concepts of Their Mode of Action
- I. Introduction
- II. Former Interpretations of the Effects of Antipyretic/Non-Narcotic Analgesic Drugs
- III. The Pituitary-Adrenal Axis and Drug-Induced Inhibition of Inflammation
- IV. The Inflammatory Focus as Site of Action of Anti-Inflammatory Drugs
- V. Summary
- References
- Chapter 4. Biochemistry of Drug Oxidation and Reduction by Enzymes in Hepatic Endoplasmic Reticulum
- I. Introduction
- II. Oxidation of Foreign Compounds by Enzymes in Hepatic Endoplasmic Reticulum
- III. Reduction of Foreign Compounds by Enzymes in Hepatic Endoplasmic Reticulum
- IV. Mechanisms of Oxidation and Reduction by Enzymes in Hepatic Endoplasmic Reticulum
- V. Factors Which Limit Drug Metabolism in Living Animals
- References
- Chapter 5. Experimental and Clinical Chemoteratogenesis
- I. Introduction
- II. General Survey
- III. General Principles
- IV. Experimental Conditions
- V. Experimental Techniques
- VI. Teratogenic Drugs
- VII. Nature and Mechanism of Action of Teratogenic Drugs
- VIII. Conclusions
- Glossary
- References
- Author Index
- Index
