Advances in Cancer Research
Academic Press
Published on 24. February 1992
223 pages
978-0-08-056240-7 (ISBN)
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Advances in Cancer Research
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G.I. Vande Woude | George F. Vande Woude | G. Klein
Advances in Cancer Research: v. 58
Book
01/1992
Academic Press
€71.92
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Content
- Front Cover
- Advances in Cancer Research
- Copyright Page
- Contents
- Contributors To Volume 58
- Chapter 1. Epstein-Barr Virus in B Lymphocytes: Viral Gene Expression and Function in Latency
- I. Natural History of the Virus and Associated Diseases
- II. Expression and Function of EBV Genes during Latency
- III. Structure of Viral Transcripts and Promoters for the EBV Latent Genes
- IV. Perspective on Viral Gene Expression in the LCL Model
- References
- Chapter 2. The Physiology of Transforming Growth Factor-a
- I. Introduction
- II. TGF-a Is a Member of a Growth Factor Family
- III. The Structure of TGF-a and Its Precursor
- IV. Interactions of TGF-a with the EGF/TGF -a Receptor
- V. The Transmembrane TGF-a Precursor
- VI. A Role for TGF -a in the Physiology of Normal Cells
- VII. TGF-a in Normal Development
- VIII. A Role for TGF -a in Tumor Development?
- References
- Chapter 3. The Role of Raf-1 Phosphorylation in Signal Transduction
- I. The raf oncogene Family
- II. Raf-1 Activation following Growth Factor Stimulation
- III. Sites of Raf-1 Phosphorylation
- IV. Consequences of Raf-1 Activation
- V. Conclusion
- References
- Chapter 4. G Protein-Controlled Signal Transduction Pathways and the Regulation of Cell Proliferation
- I. Introduction
- II. Signal Transduction by Receptors with Ligand Dependent Tyrosine Kinase Activity
- III. Signal Transduction through G Protein-Coupled Receptors
- IV. Conclusion
- References
- Chapter 5. Regulation of Muscle Cell Growth and Differentiation by the MyoD Family of Helix.Loop.Helix Proteins
- I. Introduction
- II. Evidence for Myogenic Regulatory Genes
- III. The MyoD Family of Muscle-Specific Regulatory Factors
- IV. Antagonism between Proliferation and Differentiation within the Myogenic Lineage
- V. Summary
- References
- Chapter 6. Molecular Genetic Characterization of CNS Tumor Oncogenesis
- I. Introduction
- II. Explanation of Model
- III. Comparison of Molecular Genetic and Histopathologic Analysis
- IV. Status of Identifying and Characterizing Specific Gene Alterations in CNS Tumor Development
- V. Implications of Molecular Genetic Analysis on CNS Tumor Diagnosis and Treatment
- References
- Chapter 7. Tumor Eradication by Adoptive Transfer of Cytotoxic T Lymphocytes
- I. T Cell Immunity
- II. Processing of Antigens for Recognition by T Cells
- III. Immunogenicity of Tumors
- IV. Adoptive lmmunotherapy of Virus-Induced Tumors with T Cells
- V. Escapes of Tumor Cells from Immune T Cells
- VI . Relationship of LAK Cells, TIL Cells, NK Cells, and T Cells, All with Antitumor Activity and Clinical Results of Adoptive Therapy with LAK and TIL Cells
- VII. Cloned T Cells with Autologous Tumor Specificity in Malignant Melanoma: Nature of the Melanoma Antigens
- VIII. Epilogue
- References
- Chapter 8. Toward a Genetic Analysis of Tumor Rejection Antigens
- I. Introduction
- II. tum- Antigens: Genes, Mutations, and Antigenic Peptides
- Ill. A Tumor Rejection Antigen of Tumor P815
- IV. Antigens Recognized on Human Tumors by Autologous CTLs
- V. Perspectives
- References
- Index
