Advances in Cancer Research
Academic Press
Published on 19. March 1982
338 pages
978-0-08-056217-9 (ISBN)
Description
Advances in Cancer Research
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George Klein | Sidney Weinhouse
Advances in Cancer Research: v. 35
Book
01/1981
Academic Press
€66.96
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Content
- Front Cover
- Advances in Cancer Research, Volume 35
- Copyright Page
- Contents
- Contributors to Volume 35
- Chapter 1. Polyoma T Antigens
- I. Introduction
- II. Polyoma T Antigens in Lytically Infected Cells
- III. The Polyoma DNA Nucleotide Sequence-Coding and Regulatory Signals
- IV. Structural Features of the Polyoma T Antigens-Comparison with SV40
- V. Mutations Affecting the T Antigens
- VI. Cell Transformation and Tumorigenicity
- VII. The Role of the Large T Antigen in Lytic Infection
- VIII. The Role of the Large T Antigen in Transformation
- IX. The Small and Medium T Antigens in Lytic Infection
- X. The Small and Medium T Antigens in Transformation
- XI. Functions Associated with the Small and Medium T Antigens
- References
- Chapter 2. Transformation Induced by Herpes Simplex Virus: A Potentially Novel Type of Virus-Cell Interaction
- I. Introduction
- II. Transformation-Definition of Terms
- III. Models for in Vitro Transformation by HSV
- IV. Properties of Transformed Cells
- V. Persistance of HSV Genetic Material in Transformed Cells
- VI. Mechanism of Transformation by HSV
- References
- Chapter 3. Arachidonic Acid Transformation and Tumor Production
- I. Introduction
- II. Arachidonic Acid Transformation
- III. Prostaglandin Levels in Tumors
- IV. Arachidonic Acid Transformation and Hypercalcemia
- V. Arachidonic Acid Transformation and Tumor Promotion
- VI. Prostaglandins: Their Effects on Cell or Tumor Growth
- VII. Prostaglandins and the Immune Response
- VIII. Challenges
- References
- Chapter 4. The Shope Papilloma-Carcinoma Complex of Rabbits: A Model System of Neoplastic Progression and Spontaneous Regression
- I. Introduction: Historical Origins
- II. Interaction of Shope Papilloma Virus and Host Cells
- III. Neoplastic Progression
- IV. Spontaneous Regression
- V. Shope Papilloma-Carcinoma Complex as a Model System
- References
- Chapter 5. Regulation of SV40 Gene Expression
- I. Introduction
- II. Cell Type Dependence of SV40 and PV Gene Expression
- III. Functions of SV40 Tumor Antigens
- IV. Cell Transformation
- V. Microinjection: Applications and Trends
- References
- Chapter 6. Polyamines in Mammalian Tumors Part I
- I. Introduction and Background
- II. Levels of Polyamines and Their Biosynthetic Enzymes in Fully Developed Experimental Tumors
- III. Modification in Vivo and in Vitro of Tissue Polyamine Metabolism by Chemical Carcinogens and Tumor Promoters
- IV. Biosynthesis and Levels of Polyamines in Cells during the Virus-Induced Transformation Process
- V. Changes in Polyamine Biosynthesis and Content of Target Tissues by Physical Carcinogens
- References
- Chapter 7. Criteria for Analyzing Interactions between Biologically Active Agents
- I. Introduction
- II. Effect Multiplication
- III. Effect Summation
- IV. Agent Interaction and Self-Interaction
- V. Isoboles and the Interaction Index
- VI. Criteria Based on Changes in Dose-Response Curves
- VII. Modifications of the Isobole Method
- VIII. Therapeutic Optimization
- IX. Conclusion
- References
- Index
- Contens of Previous Volumes
