Advances in Cancer Research
Academic Press
Published on 23. July 1981
327 pages
978-0-08-056216-2 (ISBN)
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Advances in Cancer Research
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George Klein | Sidney Weinhouse
Advances in Cancer Research: v. 34
Book
05/1981
Academic Press
€83.08
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Content
- Front Cover
- Advances in Cancer Research, Volume 34
- Copyright Page
- Contents
- Contributors to Volume 34
- Chapter 1. The Transformation of Cell Growth and Transmogrification of DNA Synthesis by Simian Virus 40
- I. Introduction
- II . A Definition of Transformation
- III. Normal Growth Control
- IV. Early Steps in Transformation by Virions
- V. Induction of Host DNA Synthesis and Abortive Transformation
- VI. Integration of Viral DNA into the Host Genome
- VII. Sequences Necessary for Transformation by SV40 and PyV
- VIII. SV40 Functions Required for Maintenance of the Transformed State
- IX. Comparison of PyV and SV40 Transformants
- X. The Mutagenic Activity of SV40
- XI. Gene Activation by SV40
- XII. Tumorigenicity and Tumor Rejection
- XIII. Host Control of T-Antigen
- XIV. Normal DNA Synthesis in Mammalian Cells
- XV. DNA Synthesis in SV40 Transformants
- XVI. The Enzymatic Activity of the 90K T-Antigen
- XVII. Summary
- References
- Chapter 2. Immunologic Mechanisms in UV Radiation Carcinogenesis
- I. Introduction
- II. Carcinogenesis by UV Radiation
- III. Immunosuppression and UV Carcinogenesis
- IV. Antigenicity of UV-Induced Tumors
- V. Immunologic Reactivity of Mice during UV Carcinogenesis
- VI. Mechanisms in UV-Induced Immunosuppression
- VII. Conclusions
- References
- Chapter 3. The Tumor Dormant State
- I. Introduction and Definition
- II. Review of the Clinical Literature on Tumor Dormancy
- III. Animal Models of Tumor Dormancy
- IV. Stages of Tumor Dormancy
- V. Comments
- VI. Conclusions
- References
- Chapter 4. Marker Chromosome 14q+ in Human Cancer and Leukemia
- I. Introduction
- II. Survey of the Total Material
- III. Nomenclature
- IV. General Review of Chromosome Patterns in Cancer
- V. Survey of Occurrence of 14q+ Marker Chromosomes
- VI. Survey of Geographic Distribution of 14q+ Marker Chromosomes
- VII. Relation between the 14q+ Marker Chromosome and EBV
- VIII. Summary of 14q+ Marker Chromosomes
- IX. Significance of the 14q+ Marker and Other Specific Chromosome Abnormalities
- References
- Chapter 5. Structural Diversit among Retroviral Gene Products: A Molecular Approach to the Study of Biological Function through Structural Variability
- I. Introduction
- II. Molecular Portraiture: Technique of Peptide Mapping
- III. Background, Historical Overview
- IV. The Comparative Structure of the Major Core Protein of Retroviruses
- V. Xenotropic Viruses of Different Classes Have Different p30s
- VI. N- and B-Tropism Are Cryptic Phenotypes of X-tropic MuLV
- VII. Additional Structural Markers in MuLV p30
- VIII. The Structure of MuLV p30 Is Different from the Major Core Protein of Other Mammalian Type C Viruses
- IX. Structural Evidence for Interspecies Transfer of Genetic Information
- X. Two Type C Viruses from a Single Species of Mouse Constitute Members of Both the Woolly Monkey-Gibbon Ape and Murine Groups
- XI. Structural Markers Associated with MuLV gp70
- XII. Structural Polymorphism of MuLV p15
- XIII. Structure-Function Correlates of Fv-1 Tropism
- XIV. Structural Evidence for Different Fv-1n Genes
- XV. The Use of Structural Markers on MuLV Gene Products to Identify Intragenic Recombinations
- XVI. Summary
- References
- Chapter 6. Teratocarcinomas and Other Neoplasms as Developmental Defects in Gene Expression
- I. Introduction
- II. Stem Cells in Normal Development and in Tumors
- III . Spontaneous Differentiation in Tumors
- IV. Induction of Normalization and Differentiation in Tumors and Established Cell Lines
- V. Effects of Tumor Promoters on Differentiation
- VI. Anomalous Differentiation in Metaplasia and Neoplasia
- VII. Expression of "Banal" Cellular Genes in Normalcy vs Malignancy
- References
- Note Added in Proof
- Chapter 7. Immune Deficiency Predisposing to Epstein-Barr Virus-Induced Lymphoproliferative Diseases: The X-Linked Lymphoproliferative Syndrome as a Model
- I. Introduction
- II. Immunopathogenesis of Infectious Mononucleosis
- III. Infectious Mononucleosis Mimics Graft-versus-Host Response (GVHR)
- IV. Immune Deficiency Predisposing to Fatal Lymphoproliferative Disorders
- V. X-Linked Lymphoproliferative Syndrome as a Model Illustrating Immunodeficiency Predisposing to Fatal Infectious Mononucleosis and Malignant Lymphoma
- VI. Ataxia Telangiectasia (AT), Immunodeficiency, and Chromosomal Breakage Predisposing to Malignant Lymphoproliferation
- VII. Familial Fatal Infectious Mononucleosis and EBV-Induced Lymphoproliferative Diseases
- VIII. EBV-Induced Lymphoproliferative Diseases in Transplant Recipients
- IX. Hypothesis: EBV-Induced Oncogenesis in Immunodeficiency
- X. Techniques for Detecting EBV Infection in Immune-Deficient Patients
- XI. Summary and Recommendations
- References
- Index
- Contents of Previous Volumes
