Adrenergic Activators and Inhibitors
Part I
Springer (Publisher)
Published on 6. December 2012
1223 pages
978-3-642-67505-8 (ISBN)
Description
Not much more than a decade has passed since the appearance of the outstanding handbook, Catecholamines, edited by BLASCHKO and MUSCHOLL, in the series: Handbook of Experimental Pharmacology. However, this extremely well organized volume dealt mainly with the origin, molecular actions, and fate of the naturally occuring catecholamines. It was felt that a separate volume should be dedicated to the remarkable and exciting progress made in the field of agents influencing the adrenergic system, both in physiologic and pharmacologic respect. The editor of the present volume considers himself lucky to have been able to persuade a number of eminent specialists to collaborate. The main concept of the present handbook is a systematic approach to the various effects of adrenergic activators and inhibitors starting with the chemistry and structure actitivity relationship, followed by the evaluation of adrenergic activators and inhibitors, and discussing their mode of action. The most voluminous part is the chapter dealing with the systemic pharma cology of these agents analyzing the effects on the central nervous system, on the autonomic nervous system, on the cardiovascular, the respiratory, the digestive, the endocrine system, on the skeletal muscle, and on metabolism. Kinetics and bio transformation, further toxic effects are discussed in the following chapters. A special chapter on clinical features concludes the monograph.
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Content
Section I: General Considerations.- 1 Chemistry of Alpha- and Beta-Adrenoceptor Agonists and Antagonists.- 2 Sympathomimetic Amine-Induced Responses of Effector Organs Subserved by Alpha-, Beta1-, and Beta2-Adrenoceptors.- 3 Evaluation of Adrenergic Alpha- and Beta-Receptor Activators and Adrenergic Alpha- and Beta-Receptor Blocking Agents.- 4 Evaluation of Agents That Release or Modify Release of Adrenergic Transmitter.- 5 Catecholamine Receptors on Nerve Terminals.- 6 Adrenergic Agents, Calcium Ions, and Cyclic Nucleotides in the Control of Cell Proliferation.- 7 Effects on the Metabolism.- Section II: Effects on the Autonomic and on the Central Nervous System.- A. Presynaptic Receptors in the Autonomic Nervous System.- B. Adrenergic Activators and Inhibitors on the Central Nervous System.- 1 Regulation of Monoamine Synthesis and Utilization by Receptors.- 2 Interactions of Opiates and Endorphins With Cerebral Catecholamines.- 3 Behavioural Pharmacology Reflecting Catecholamine Neurotransmission.- 4 Regulation of the Arterial Blood Pressure.- 5 Catecholamines and the Regulation of Body Temperature.- 6 Regulation of Food Intake.- 7 Regulation of Water Intake.- Section III: Effects on the Cardiovascular System.- 1 Effect of Adrenergic Activators and Inhibitors on the Electrical Activity of the Heart.- 2 Effects of Beta- and Alpha-Adrenoceptor Activators and Adrenergic Transmitter Releasing Agents on the Mechanical Activity of the Heart.- 3 Effects of Adrenergic Activators and Inhibitors on the Coronary Circulation.- 4 Effects on Myocardial Metabolism.- 5 Effects on the General Hemodynamics and Peripheral Circulation.- Author Index.
