Animal Models of Inflammatory Bowel Disease
Contribution to the 1st International Conference on Inflammatory Bowel Disease Animal Models, Berlin, December 2001. Special Issue: 'Pathobiology' 2002/2003, Vol. 70, No 3. Special Topic Issue: Pathobiology 2002/2003, Vol. 70, No. 3
Published on 7. February 2003
Book
Paperback/Softback
76 pages
978-3-8055-7522-5 (ISBN)
Description
Animal models are important both for a better understanding of the pathogenesis of inflammatory bowel disease (IBD) and for the development of improved therapies. Combining the expertise of internationally renowned experts in immunology, microbiology, and gastroenterology, this special issue of Pathobiology provides comprehensive coverage of findings in the field. I n a first part, the role of commensal bacteria and IL-2 in murine models is investigated. Besides, data are presented indicating that neutrophils as well as gd T lymphocytes contribute to the protection of the epithelial intestinal surface. The second part is dedicated to the immunopathogenesis of IBD and considers closely the roles played by T cell subsets and dendritic cells. Furthermore, various aspects regarding new therapeutic strategies are described. Based on our latest understanding of IBD pathophysiology, therapies targeting key cytokines (i.e. IL-18, IL-6, and IL-12) as well as important adhesion receptors (i.e. CD44) are discussed.
More details
Language
English
Place of publication
Basel
Switzerland
Target group
College/higher education
Professional and scholarly
Illustrations
23
5 s/w Tabellen, 23 s/w Abbildungen
23 fig., 5 tab.
Dimensions
Height: 28 cm
Width: 21 cm
Weight
260 gr
ISBN-13
978-3-8055-7522-5 (9783805575225)
Schweitzer Classification
Content
The flora and intestinal barrier in IBD animal models: role of commensal bacteria in chronic experimental colitis - lessons from the HLA-B27 transegic rat, H.C. Rath; the interleukin-2-deficient mouse model, C. Barmeyer, I. Horak, M. Zeitz, M, Fromm, J.D. Schulze; neutrophil migration accross the intestinal epithelial barrier, T. Kucharzik, I.R. Williams; role of gamma delta T cells in inflammatory bowel disease, A.A. Kuhl, C. Loddenkemper, J. Westermann, J.C. Hoffman. Immunopathogenesis in IBD animal models: early events in the pathogenesis of a murine transfer colitis, F. Leithauser, T. Krajina, Z. Trobonjaca, J. Reimann; anti-interleukin-18 therapy in murine models of IBD, M. Lochner, I. Forster; a new model of chronic colitis in SCID mice induced by adoptive transfer of CD62L+CD4+ T cells - insights into the regulatory role of interleukin-6 on apoptosis, J. Mudter, S. Wirtz, P.R. Galle, M.F. Neurath; interleukin-12 antagonists as new therapeutic agents in IBD, C. Schmidt, T. Martha, B.M. Wittig, A. Hombach, H. Abken, A, Stallmach; functional involvement of CD44 variant 7 in gut immune response, B.M. Wittig, A. Stallmach, M. Zeitz, U. Gunthert.