Genome Science: Towards a New Paradigm?

Preface. Genome science today and tomorrow (H. Yoshikawa). Genomic view of the cell. Just so genome stories: what does my neighbor tell me? (S. Noria, A. Danchin). Genome biology of a model bacterium, bacillus subtilis (K. Kobayashi, N. Ogasawara). Mitochondrial protein flux (T. Endo). Peroxisome assembly and peroxisome biogenesis disorders (Y. Fujiki). Toward the global analysis of cellular signaling pathways (H. Taniguchi, Y. Murata, E. Yamauchi). Regulation of the phospholipase C-a2 pathway in B cells (T. Kurosaki). Generation and phenotypic analysis of conditionally inactivated mutant cells (E. Sonoda et al.). E-CELL: towards computer simulation of the whole cell (M. Tomita). Genomic view of development. Deciphering the eye morphogenetic pathway (W.J. Gehring, L. Michaut). Mitogen-activated protein kinase pathways in C. elegans (N. Hisamoto, R. Sakamoto, K. Matsumoto). From evolutionary developmental biology to genomics: towards a genome map of the free-living nematode Pristionchus pacificus (J. Srinivasan, R.J. Sommer). Genomic approaches to early development of C. elegans (Y. Kohara). A genome scientific view of ascidian development (N. Satoh, Y. Satou). Genomic view of diversity. Diversity of the cadherin-related neuronal receptor family in the nervous system (T. Yagi et al.). On the roles of mutation and selection in genome evolution: a population genetic approach (H. Tachida). Epigenetic regulation in mammalian development and dysfunction: the effects of somatic cloning and genomic imprinting (T. Kohda et al.). Imprinting cluster and domain regulation in Kip2/Lit1 subdomain on mouse chromosome 7F4/F5 (T. Mukai et al.). A preliminary comparison of the mouse and human genomes (R.J. Mural et al.). Chimpanzee genome project for understanding ourselves (Y. Sakaki). Genome evolution. Life cycle of restriction-modification gene complexes, powers in genome evolution (I. Kobayashi) Origin and evolution of the plant genome; with a focus on mitochondrial and plastid genomes (N. Ohta, T. Kuroiwa). Early evolution of eukaryotes inferred from genome data (N. Arisue, T. Hashimoto, M. Hasegawa). Exploiting genomics in evolutionary developmental biology (P.W.H. Holland et al.). Human genome. Oligo-capped cDNAs for promoter indentification and annotation (S. Sugano). Approaches to identifying genetic variation for complex phenotypes (N.J. Cox). Identification of candidate tumor suppressor genes from critical deletions of long arm of chromosome 6 in hematopoietic neoplasm (S. Ogawa, A. Hangaishi, H. Hirai). Understanding cancer through gene expression profiling (H. Aburatani). Author index. Keyword index.