
Side Reactions in Peptide Synthesis
Yi Yang(Author)
Academic Press
Published on 8. September 2015
Book
Hardback
376 pages
978-0-12-801009-9 (ISBN)
Description
Side Reactions in Peptide Synthesis, based on the author's academic and industrial experience, and backed by a thorough review of the current literature, provides analysis of, and proposes solutions to, the most frequently encountered side reactions during peptide and peptidomimetic synthesis.
This valuable handbook is ideal for research and process chemists working with peptide synthesis in diverse settings across academic, biotech, and pharmaceutical research and development.
While peptide chemistry is increasingly prevalent, common side reactions and their causes are often poorly understood or anticipated, causing unnecessary waste of materials and delay.
Each chapter discusses common side reactions through detailed chemical equations, proposed mechanisms (if any), theoretical background, and finally, a variety of possible solutions to avoid or alleviate the specified side reaction.
This valuable handbook is ideal for research and process chemists working with peptide synthesis in diverse settings across academic, biotech, and pharmaceutical research and development.
While peptide chemistry is increasingly prevalent, common side reactions and their causes are often poorly understood or anticipated, causing unnecessary waste of materials and delay.
Each chapter discusses common side reactions through detailed chemical equations, proposed mechanisms (if any), theoretical background, and finally, a variety of possible solutions to avoid or alleviate the specified side reaction.
More details
Language
English
Place of publication
San Diego
United States
Publishing group
Elsevier Science Publishing Co Inc
Target group
Professional and scholarly
Pharmaceutical and process chemists at CMO and CRO companies, research/R&D chemists at universities, institutes,
Product notice
Laminated cover
Dimensions
Height: 236 mm
Width: 156 mm
Thickness: 30 mm
Weight
682 gr
ISBN-13
978-0-12-801009-9 (9780128010099)
Copyright in bibliographic data and cover images is held by Nielsen Book Services Limited or by the publishers or by their respective licensors: all rights reserved.
Schweitzer Classification
Other editions
Additional editions

E-Book
09/2015
Academic Press
€71.95
Available for download
Person
Yi Yang began researching peptide synthesis in 2003, and obtained his doctoral degree at Bielefeld University, Germany in 2008. Dr. Yang worked for three years at Lonza AG, Visp, Switzerland as R&D and Process Peptide Chemist, participated in multi cGMP peptidyl API production at Lonza, which is regarded as one of the largest peptide contract manufacturing organization (CMO) in the world, serving pharmaceutical companies. He is currently the Senior Research Scientist of Chemical Development, Global Pharmaceutical R&D, Ferring Pharmaceuticals A/S, Copenhagen, Denmark. Dr. Yang's experience with a wide variety of peptide side reactions, from both practical and theoretical aspects, is ideal for this publication.
Author
PhD, Senior Research Scientist, Chemical Development, Global Pharmaceutical R&D, Ferring Pharmaceuticals A/S, Copenhagen, Denmark
Content
Peptide Fragmentation/Deletion
Premature FMOC Deprotection
Elimination Side Reactions
Peptide Global Deprotection/Scavenger-Induced Side Reactions
Peptide Rearrangement Side Reactions
Side Reactions Occurring at Amino Acid/Peptide Activation Step
Intramolecular Cyclization Side Reactions
Side Reactions in Amino Groups in Peptide Synthesis
Side Reactions in Hydroxyl, Carboxyl, Ester Groups in Peptide Synthesis
Oxidation and Reduction Side Reactions in Peptide Synthesis
Racemization in Peptide Synthesis
Solvent and Residual Impurities in the Reagents Induced Side Reactions
Dipeptide Formation Side Reactions (Redundant Amino Acid Incorporation)
Reattachment of Peptides to the Solid Supports
Addition Side Reactions in Peptide Synthesis
Side Reactions in Phosphor Peptides
Side Reactions in CYS
Protein Fragmentations
Premature FMOC Deprotection
Elimination Side Reactions
Peptide Global Deprotection/Scavenger-Induced Side Reactions
Peptide Rearrangement Side Reactions
Side Reactions Occurring at Amino Acid/Peptide Activation Step
Intramolecular Cyclization Side Reactions
Side Reactions in Amino Groups in Peptide Synthesis
Side Reactions in Hydroxyl, Carboxyl, Ester Groups in Peptide Synthesis
Oxidation and Reduction Side Reactions in Peptide Synthesis
Racemization in Peptide Synthesis
Solvent and Residual Impurities in the Reagents Induced Side Reactions
Dipeptide Formation Side Reactions (Redundant Amino Acid Incorporation)
Reattachment of Peptides to the Solid Supports
Addition Side Reactions in Peptide Synthesis
Side Reactions in Phosphor Peptides
Side Reactions in CYS
Protein Fragmentations