
Apoptosis
Morgan & Claypool Publishers
Published on 1. April 2013
Book
Paperback/Softback
101 pages
978-1-61504-538-9 (ISBN)
Description
Multi-cellular organisms eliminate individual cells through a self-destruct process known as apoptosis. Apoptosis is critical for proper development and maintenance of tissue homeostasis. The importance of this process is highlighted by the fact that too much or too little apoptosis is the underlying cause of pathologies such as cancer, autoimmune diseases (e.g., lupus, arthritis), and neurodegenerative disorders (e.g., Parkinson's, Alzheimer's). In the early days, apoptotic cells were identified strictly by cell morphology. Now we know that biochemical signatures define a number of death programs, of which apoptosis is the most widely understood. In this review, we discuss genetic insights gained from C. elegans, the importance of caspases, engulfment of apoptotic cells, apoptotic signals, the role of mitochondria, the Bcl-2 family, and the link between dysfunctional apoptosis and disease. Within each topic, we highlight landmark studies that contributed to our current understanding of apoptosis. All together, this research exemplifies tremendous scientific synergy between the disciplines of genetics, biochemistry, developmental cell biology, and structural biology. Continued exploration into mechanisms that regulate apoptosis will undoubtedly lead to insights into disease processes with potential therapeutic strategies.
More details
Series
Language
English
Place of publication
San Rafael
United States
Dimensions
Height: 235 mm
Width: 191 mm
Thickness: 6 mm
Weight
219 gr
ISBN-13
978-1-61504-538-9 (9781615045389)
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Schweitzer Classification
Content
- Historical Perspective of Apoptosis
- C. elegans and Discovery of the Caspases
- Engulfment of Apoptotic Cells: "Find Me" and "Eat Me" Signals
- Extrinsic and Intrinsic Apoptotic Signals
- The Bcl-2 Family
- Apoptosis and Cancer
- Summary
- References
- Author Biographies
- C. elegans and Discovery of the Caspases
- Engulfment of Apoptotic Cells: "Find Me" and "Eat Me" Signals
- Extrinsic and Intrinsic Apoptotic Signals
- The Bcl-2 Family
- Apoptosis and Cancer
- Summary
- References
- Author Biographies