
Matrix Metalloproteinases and TIMPs
Oxford University Press
2nd Edition
Published on 23. March 2000
Book
Paperback/Softback
238 pages
978-0-19-850268-5 (ISBN)
Description
The matrix metalloproteinases (MMPs) are a large family of enzymes that break down different components of the extracellular matrix. Their catalytic activity is dependent on the metal ion zinc. This issue of the Protein Profiles covers the sequence information, three-dimensional structures, activation, protein substrates, specificity requirements, inhibition, and biological roles of all the currently identified MMPs. The action of these enzymes must be carefully regulated. One way the cell does this is by releasing inhibitory molecules known as tissue inhibitors of metalloproteinases (TIMPs). This volume contains information on the sequences, three-dimensional structures, and biological roles of the four known TIMPs. Matrix metalloproteinases and TIMPs will therefore be an invaluable source of data for all researchers interested in MMPs and TIMPS.
More details
Series
Edition
2. Auflage
Language
English
Place of publication
Oxford
United Kingdom
Target group
Professional and scholarly
Illustrations
23 line figures
Dimensions
Height: 246 mm
Width: 189 mm
Thickness: 13 mm
Weight
473 gr
ISBN-13
978-0-19-850268-5 (9780198502685)
Copyright in bibliographic data and cover images is held by Nielsen Book Services Limited or by the publishers or by their respective licensors: all rights reserved.
Schweitzer Classification
Persons
Author
Department of Biochemistry and Molecular BiologyDepartment of Biochemistry and Molecular Biology, University of Miami School of Medicine, USAUSA
Kennedy Institute, LondonKennedy Institute, London
Content
ABBREVIATIONS; INTRODUCTION; MMP SEQUENCES; TIMP SEQUENCES; THREE DIMENSIONAL STRUCTURES OF THE MMPS AND TIMPS; ACTIVATION OF THE ZYMOGEN FORMS OF MMPS; PROTEIN SUBSTRATES OF THE MMPS; SPECIFICITY REQUIREMENTS OF THE MMPS; INHIBITION OF THE MMPS; BIOLOGICAL ROLES OF THE MMPS; FUNCTIONS OF THE TIMPS; BIBLIOGRAPHY; PROTEIN SEQUENCE ALIGNMENTS