Potassium Channel Modulators
Pharmacological, Molecular and Clinical Aspects
Published on 27. October 1992
Book
Hardback
528 pages
978-0-632-03044-6 (ISBN)
Description
Modulation of potassium channels plays a very important part in nerve cell function in the autonomic nervous system. Compounds are now in development which can open or close potassium channels and will have numerous therapeutic applications. The major areas of clinical relevance will be hypertension, asthma and irritable bladder syndrome. The book describes the pharmacology
More details
Series
Language
English
Place of publication
Oxford
United Kingdom
Publishing group
John Wiley and Sons Ltd
Target group
College/higher education
Professional and scholarly
Illustrations
102
Dimensions
Height: 234 mm
Width: 156 mm
Weight
1138 gr
ISBN-13
978-0-632-03044-6 (9780632030446)
Copyright in bibliographic data is held by Nielsen Book Services Limited or its licensors: all rights reserved.
Schweitzer Classification
Content
Potassium channels in excitable cells: a synopsis; Potassium channel genes: genomic complexity, molecular properties, and differential expression; Cloning and pharmacology of voltage-gated potassium channels; G proteins and the modulation of potassium channels; High conductance calcium-activated potassium channels: molecular pharmacology, purification and regulation; The physiology and pharmacology of ATP-regulated potassium channels in insulin-secreting cells; Smooth muscle potassium channels: their electrophysiology and function; Potassium channels in the heart: physiological function and neurohormonal regulation; Potassium channels in mammalian neurones: their properties and prospects for pharmacological manipulation; Skeletal muscle potassium channels and their relevance to muscle disease; Naturally occurring potassium channel blockers; Potassium channel blockers: synthetic agents and their antiarrhythmic potential; Potassium channel activators: structure-activity relationships; Effects of potassium channel modulators on the cardiovascular system; The pharmacology of potassium channel modulators in airways smooth muscle: relevance to airways disease; Potassium channel modulators - urogenital pharmacology; Potassium channel openers: clinical aspects