Genetic Variation and Human Disease
Principles and Evolutionary Approaches
Published on 27. May 1993
Book
Hardback
378 pages
978-0-521-33421-1 (ISBN)
Description
Recent developments in molecular and computational methods have made it possible to identify the genetic basis of any biological trait, and have led to spectacular advances in the study of human disease. This book provides an overview of the concepts and methods needed to understand the genetic basis of biological traits, including disease, in humans. Using examples of qualitative and quantitative phenotypes, Professor Weiss shows how genetic variation may be quantified, and how relationships between genotype and phenotype may be inferred. This book will appeal to many biologists and biological anthropologists interested in the genetic basis of biological traits, as well as to epidemiologists, biomedical scientists, human geneticists and molecular biologists.
Reviews / Votes
'A well-documented, clearly written, scholarly text.' S. Antonarakis, Trends in Genetics 'By far the best introduction to the subject that I have read.' D. Weatherall, Science PublicityMore details
Series
Language
English
Place of publication
Cambridge
United Kingdom
Target group
Professional and scholarly
Illustrations
42 Tables, unspecified; 1 Halftones, unspecified; 70 Line drawings, unspecified
Dimensions
Height: 236 mm
Width: 157 mm
Thickness: 25 mm
Weight
662 gr
ISBN-13
978-0-521-33421-1 (9780521334211)
Copyright in bibliographic data and cover images is held by Nielsen Book Services Limited or by the publishers or by their respective licensors: all rights reserved.
Schweitzer Classification
Other editions
New editions
Book
01/1995
Cambridge University Press
€63.00
Shipment within 15-20 days
Kenneth M. Weiss | Joseph D. Terwilliger
Genetic Variation and Human Disease
Principles and Evolutionary Approaches
Book
2nd Edition
Cambridge University Press
Unfortunately, price unknown
The article will not be published
Additional editions
Book
01/1995
Cambridge University Press
€63.00
Shipment within 15-20 days
Person
Content
Preface; Part I. Genes and Their Expression: 1. What is a gene?; 2. The logic of the genome; 3. Concepts of frequency and association in populations; 4. Genes and phenotypes in populations; Part II. Introduction to Genetic Epidemiology: Inference from Observational Data: 5. Segregation analysis: discrete traits in families; 6. Segregation analysis: quantitative traits in families; 7. Linkage analysis: finding and mapping genes for qualitative traits; 8. Linkage analysis: finding and mapping genes for quantitative traits; Part III. Evolution: The Time Dimension in Populations: 9. Genes over time and space; 10. Reconstructing history: the footprints of evolution; 11. Evolution generates heterogeneity; Part IV. Modification of the Inherited Genotype: The Time Dimension in Individuals: 12. Phenotype amplification by the environment; 13. Infectious disease: the response to biological challenge; 14. Variation within the inherited genotype; 15. Cancer and ageing: a microcosm of evolution during life; Afterwords: towards a unified general model; Conclusion; Notes; References; Index.