Protein Degradation with New Chemical Modalities

PROTAC-mediated Target Degradation: A Paradigm Changer in Drug Discovery?;

Structural and Biophysical Principles of Degrader Ternary Complexes;

Immediate and Selective Control of Protein Abundance using the dTAG System;

Developing Pharmacokinetic/Pharmacodynamic Relationships with PROTACs;

New Activities of CELMoDs, Cereblon E3 Ligase Modulating Drugs;

Structure-based PROTACs Design;

Plate-Based High Throughput Cellular Degradation Assays to Identify PROTACS Molecules and Protein Degraders;

PROTAC Targeting BTK for the Treatment of Ibrutinib-Resistant B-Cell Malignancies;

An Efficient Approach Toward Drugging Undruggable Targets;

E3-Mediated Ubiquitin and Ubiquitin-like Protein Ligation: Mechanisms and Chemical Probes;

Plant E3 Ligases as Versatile Tools for Novel Drug Development and Plant Bioengineering;

Deubiquitinase Inhibitors: An Emerging Therapeutic Class;

Targeting Translation Regulation for the Development of Novel Drugs;

Classes, Modes-of-action and Selection of New Modalities in Drug Discovery;

Small Molecule Targeted Degradation of RNA