Advances in Enzyme Regulation: Vol 34
Proceedings of the Thirty Fourth Symposium on Regulation of Enzyme Activity and Synthesis in Normal and Neoplastic Tissues, Held at Indiana University School of Medicine, Indianapolis, Indiana, USA, 4-5 October 1993
Published on 29. June 1994
Book
Hardback
498 pages
978-0-08-042482-8 (ISBN)
Description
This internationally acclaimed annual series reports progress at the cutting edge in the strategic area of regulation at the molecular level. In an integrated presentation of original papers, leading scientists, Nobel prize winners and other outstanding experts from many countries review the best research produced each year and evaluate what is newest and what promises to be the most important in clinical and basic investigations. The volumes serve as guideposts and beacons for investigators in planning research and teaching students in basic and clinical fields of endeavour. These books advance the general front of studies on metabolic regulation and the understanding of the molecular biology of control of gene expression by hormones, drugs and growth factors in cancer cells and in clinical situations of diabetes, inborn errors of metabolism and neoplasia.
This internationally acclaimed annual series reports progress at the cutting edge in the strategic area of regulation at the molecular level. In an integrated presentation of original papers, leading scientists, Nobel prize winners and other outstanding experts from many countries review the best research produced each year and evaluate what is newest and what promises to be the most important in clinical and basic investigations. The volumes serve as guideposts and beacons for investigators in planning research and teaching students in basic and clinical fields of endeavour. These books advance the general front of studies on metabolic regulation and the understanding of the molecular biology of control of gene expression by hormones, drugs and growth factors in cancer cells and in clinical situations of diabetes, inborn errors of metabolism and neoplasia.
This internationally acclaimed annual series reports progress at the cutting edge in the strategic area of regulation at the molecular level. In an integrated presentation of original papers, leading scientists, Nobel prize winners and other outstanding experts from many countries review the best research produced each year and evaluate what is newest and what promises to be the most important in clinical and basic investigations. The volumes serve as guideposts and beacons for investigators in planning research and teaching students in basic and clinical fields of endeavour. These books advance the general front of studies on metabolic regulation and the understanding of the molecular biology of control of gene expression by hormones, drugs and growth factors in cancer cells and in clinical situations of diabetes, inborn errors of metabolism and neoplasia.
More details
Series
Language
English
Place of publication
Amsterdam
Netherlands
Publishing group
Elsevier Science & Technology
Target group
Professional and scholarly
Illustrations
200 illustrations, 1000 references
ISBN-13
978-0-08-042482-8 (9780080424828)
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Schweitzer Classification
Content
Part 1 Enzymes in neoplasia, carcinogenesis and resistance: use of nucleoside kinase-deficient mouse leukemia L1210 cell lines to determine metabolic routes of activation of antitumor nucleoside analogs, A.H. Cory and J.G. Cory; heterogeneous (positional) expression of hepatic glutamine synthetase - features, regulation and implications for hepatocarcinogenesis, R. Gebhardt et al. Part 2 Enzymes as targets: modulation of target enzyme associated with the action of antifolates, Y.M. Rustum et al; targeted and non-targeted action of anticancer drugs, G. Weber and N. Prajda. Part 3 Regulation of IMP dehydrogenase: inosine-5'-monophosphate dehydrogenase activity is maintained in immortalized murine cells growth-arrested by serum deprivation, P.B. Stadler et al; pharmacodynamics of the inhibition of GTP synthesis in vivo by mycophenolic acid, T.J. Franklin and W.P. Morris. Part 4 Oncogene targeting and signalling: lipid-dependent nuclear signalling - morphological and functional features, N.M. Maraldi et al. Part 5 Enzymes, receptors and cell regulation: mechanism and regulation of antigen processing by cathepsin B, N. Katunuma et al; a genetic analysis of processes regulating cytochrome P4501A1 expression, O. Hankinson. Part 6 Enzymes in growth control: serine/threonine phosphatases in the control of cell function, A. Depaoli-Roach et al; human casein kinase II - structures, genes, expressions and requirement in cell growth stimulation, W. Pyerin. Part 7 Suppressor activity and transformation: molecular cloning and characterization of a cDNA showing tumor-suppressive activity in v-src transformed 3Y1 rat fibroblasts, S. Sakiyama et al; role of protein kinase C in ras-mediated fos expression, F. Uberall et al. Part 8 Protein conformation and regulation: predicting the conformation of proteins from sequences - progress and future progress, S.A. Benner et al; the multifunctional role of hormone-sensitive lipase in lipid metabolism, S.J. Yeaman et al. Part 9 Export pumps and glycoproteins: ATP-dependent export pumps and their inhibition by cyclosporins, M. Bohme et al; the mammalian UV response, P. Herrlich et al. Part 10 Special symposium lecture: the methotrexate story - a paradigm for development of cancer chemotherapeutic agents, F.M. Huennekens. (Part Contents).