Advances in Enzyme Regulation: Vol 27

SESSION I. REGULATION OF RESISTANCE (Session Chairman: D. Keppler). Alterations in the Properties of Mouse Leukemia L1210 Cell Lines Selected by Different Methods for Resistance to Deoxyguanosine (J. G. Cory, T. O. Nelson, L. Somerville, A.H. Cory). Novel Mechanisms of Resistance to Inhibitors of DNA Topoisomerases (W.T. Beck, T. Khelifa, H. Kusumoto, Y.Y. Mo, Q. Rodgers, J.S. Wolverton, Q. Wang). SESSION II. CONTROL OF PHOSPHOLIPASE (Session Chairman: J. G. Cory). Role and Regulation of Phospholipase D Activity in Normal and Cancer Cells (M.J.O. Wakelam, A. Martin, M.N. Hodgkin, F. Brown, T.R. Pettitt, M.J. Cross, P.G. de Takats, J.L. Reynolds). Regulation of the Signal Transduction Program by Drugs (G. Weber, F. Shen, N. Prajda, H. Yang, W. Li, A. Yeh, B. Csoyay, E. Olah, K.Y. Look). SESSION III. TRANSPORT AND PRODRUG. (Session Chairman: I. Sarosi). Regulation of Carrier-mediated Transport of Folates and Antifolates in Methotrexate-sensitive and -resistant Leukemia Cells (G. Jansen, R.M. Mauritz, Y.G. Assaraf, H. Sprecher, S. Drori, I. Kathmann, G.R. Westerhof, D.G. Priest, M. Bunni, H.M. Pinedo, J.H. Schornagel, G.J. Peters). Development of Methotrexate alpha-Peptides as Prodrugs for Activation by Enzyme-monoclonal Antibody Conjugates (F.M. Huennekens). SESSION IV. REGULATION OF KEY ENZYMES. (Session Chairman: W.T. Beck). Recent Advances in the Study of rTS Proteins rTS Expression During Growth and in Response to Thymidylate Synthase Inhibitors in Human Tumor Cells (B.J. Dolnick, K. Lu, M.-B. Yin, Y.M. Rustum). Neurotrophin Stimulation of Human Melanoma Cell Invasion: Selected Enhancement of Heparanase Activity and Heparanase Degradation of Specific Heparan Sulfate Subpopulations (D. Marchetti, G.L. Nicolson). Autotaxin, Tumor Motility-stimulating Exophosphodiesterase (M.L. Stracke, T. Clair, L.A. Liotta). SESSION V. NOVEL TARGETS IN CANCER CELLS. (Session Chairman: H. L. Pearce). Antineoplastic Drugs that Interfere with Iron Metabolism in Cancer Cells (J.F. Head, F. Wang, R.L. Elliott). Design of Nitric Oxide Synthase Inhibitors and Their Use to Reverse Hypotension Associated with Cancer Immunotherapy (O.W. Griffith, R.G. Kilbourn). SESSION VI. REGULATION OF IMMUNE AND GROWTH FUNCTIONS. (Session Chairman: O. Greengard). N-3 Polyunsaturated Fatty Acids and Immune Cell Function (P.C. Calder). PHAS Proteins as Mediators of the Actions of Insulin, Growth Factors, and cAMP on Protein Synthesis and Cell Proliferation (J. Lawrence, P. Fadden, T.A.J. Haystead, T.-A. Lin). SESSION VII. CONTROL OF MITOCHONDRIAL ENZYMES. (Session Chairman: C. L. Carpenter). Studies on the Regulation of the Mitochondrial alpha-Ketoacid Dehydrogenase Complexes and their Kinases (R.A. Harris, J.W. Hawes, K.M. Popov, Y. Zhao, Y. Shimomura, J. Sato, J. Jaskiewicz, T.D. Hurley).