Drug Bioavailability

Preface.Foreword.List of Authors.I. STUDIES OF MEMBRANE PERMEABILITY AND ORAL ABSORPTION.1. Physico-chemical Approaches to Drug Absorption (H. van de Waterbeemd).2. High-throughput Measurement of log D and pKa (J. Comer).3. High-throughput Measurement of Permeability Profiles (A. Avdeef).4. Caco-2 and Emerging Alternatives for Prediction of Intestinal Drug Transport: A General Overview (P. Artursson & S. Tavelin).5. Cell Cultures in Drug Discovery: An Industrial Perspective (A. Ungell & J. Karlsson).6. Use of Animals for the Determination of Absorption and Bioavailability (C. Logan).7. In Vivo Permeability Studies in the Gastrointestinal Tract of Humans (N. Petri & H. Lennernas).II. DRUG DISSOLUTION AND SOLUBILITY.8. Gastrointestinal Dissolution and Absorption of Drugs (G. Granero, et al.).9. Aqueous Solubility in Discovery, Chemistry, and Assay Changes (C. Lipinski).10. Factors Influencing the Water Solubilities of Crystalline Drugs (J. McFarland, et al.).III. ROLE OF TRANSPORTERS AND METABOLISM IN ORAL ABSORPTION.11. Transporters in the GI Tract (H. Shin, et al.).12. Hepatic Transport (H. Suzuki & Y. Sugiyama).13. The Importance of Gut Wall Metabolism in Determining Drug Bioavailability (K. Beaumont).14. Modified Cell Lines (C. Crespi).IV. COMPUTATIONAL APPROACHES TO DRUG ABSORPTION AND BIOAVAILABILITY.15. Intestinal Absorption: The Role of Polar Surface Area (P. Artursson & C. Bergstrom).16. Calculated Molecular Properties and Multivariate Statistical Analysis in Absorption Prediction (U. Norinder & M. Haeberlein).17. VOLSURF: A Tool for Drug ADME-properties Prediction (G. Cruciani, et al.).18. Simulation of Absorption, Metabolism, and Bioavailability (M. Bolger, et al.).19. Prediction of Bioavailability (A. Mandagere & B. Jones).20. Towards P-Glycoprotein Structure-Activity Relationships (A. Seelig, et al.).V. DRUG DEVELOPMENT ISSUES.21. Application of the Biopharmaceutical Classification System Now and in the Future (B. Abrahamsson & H. Lennernas).22. Prodrugs (B. Steffansen, et al.).23. Modern Delivery Strategies: Physiological Considerations for Orally Administered Medications (C. Wilson).Index.