Comprehensive Medicinal Chemistry II, Volume 5
ADME-TOX APPROACHES
Published on 29. November 2006
Book
Hardback
1181 pages
978-0-08-044518-2 (ISBN)
Description
To be effective a drug must be Absorbed then Distributed to the site of action. It must also be Metabolised and Excreted without any measurable Toxicity (ADMET). This volume examines major ADMET issues, tools to measure these properties in vivo and in vitro and in-silico tools to predict and analyse effects. It concludes with a review of tools that can assist drug discovery in its early development stage.
More details
Language
English
Place of publication
Oxford
United Kingdom
Publishing group
Elsevier Science & Technology
Target group
Professional and scholarly
For students and researchers in chemistry, biochemistry, medicinal chemistry and pharmacology and scientists working in the pharmaceutical industries.
Dimensions
Height: 262 mm
Width: 192 mm
Weight
2940 gr
ISBN-13
978-0-08-044518-2 (9780080445182)
Copyright in bibliographic data and cover images is held by Nielsen Book Services Limited or by the publishers or by their respective licensors: all rights reserved.
Schweitzer Classification
Persons
Content
Volume 5 ADME-Tox Approaches
Introduction
Biological and In Vivo Aspects of Absorption, Distribution, Metabolism, Excretion, and Toxicity
Biological In Vitro Tools in Absorption, Distribution, Metabolism, Excretion, and Toxicity
Physicochemical tools in Absorption, Distribution, Metabolism, Excretion, and Toxicity
In Silico Tools in Absorption, Distribution, Metabolism, Excretion, and Toxicity
Enabling Absorption, Distribution, Metabolism, Excretion, and Toxicity Strategies and Technologies in Early Development
Introduction
Biological and In Vivo Aspects of Absorption, Distribution, Metabolism, Excretion, and Toxicity
Biological In Vitro Tools in Absorption, Distribution, Metabolism, Excretion, and Toxicity
Physicochemical tools in Absorption, Distribution, Metabolism, Excretion, and Toxicity
In Silico Tools in Absorption, Distribution, Metabolism, Excretion, and Toxicity
Enabling Absorption, Distribution, Metabolism, Excretion, and Toxicity Strategies and Technologies in Early Development